Application of osrodendranthus spicatus(Thunb.)C.Y.Wu leaf extract

A technology of extract, grass leaf, applied in the field of application of cat's whiskers leaf extract

Active Publication Date: 2018-10-23
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the regulatory effect of cat's whiskers on hyperlipidemia, oxidative stress and kidney damage caused by high-fat diet has not been reported yet.

Method used

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  • Application of osrodendranthus spicatus(Thunb.)C.Y.Wu leaf extract
  • Application of osrodendranthus spicatus(Thunb.)C.Y.Wu leaf extract
  • Application of osrodendranthus spicatus(Thunb.)C.Y.Wu leaf extract

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Embodiment 1

[0023] 1. Extraction method of Osmanthus fragrans leaf extract (OS): Take 500g of Osmanthus fragrans leaves, add 25L of 50% ethanol to soak at room temperature for 24 hours, stir while soaking, and treat with 280W ultrasonic wave for 30 minutes. The extract was filtered with medium-speed quantitative filter paper (pore size 20-50 μm), concentrated by rotary evaporation and then freeze-dried. The powder was weighed and the calculated yield was 9.89%. The extract was stored in a desiccator.

[0024] 2. Mice grouping and modeling: 60 15-20g male C57BL / 6 mice were randomly divided into 5 groups, namely control group, model group, high-dose (HOS) group, middle-dose (MOS) group and low-dose Dose (LOS) group, 12 rats in each group.

[0025] The mice were adaptively fed for 1 week in a clean feeding environment (light / dark time 12h / 12h, temperature controlled at 23±2°C), and the normal feed was gradually replaced with the experimental feed during the adaptation period. The test perio...

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Abstract

The invention discloses an application of an osrodendranthus spicatus(Thunb.)C.Y.Wu leaf extract in preparation of drugs for treating renal injury. Tests confirm that OS has a regulating effect on mice chronic renal injury induced by high fat diet; different doses of OS can reduce mice renal injury induced by high fat diet to different degrees; the effect of the OS with high dose (500 mg / kg) is the most obvious, and the effect is closely related to a fact that the OS can well reduce high blood fat and oxidative stress levels in the mice with high fat diet. Therefore, the srodendranthus spicatus(Thunb.)C.Y.Wu leaf extract has wide application in preparation of the drugs for treating renal injury.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of the leaf extract (OS) of cat's whiskers. Background technique [0002] Cat's whiskers (OSrodendranthus spicatus (Thunb.) C.Y.Wu), also known as kidney tea and cat's whiskers, are known as "the most fresh in the world", rich in flavonoids, phenols, terpenes, lignans, and chromogens Alkenes, alkyl glycosides, steroidal saponins, anthraquinones, amino acids, organic acids, vitamins, minerals and other active ingredients. Yam et al found that cat's whiskers water and methanol extracts can better scavenge DPPH free radicals and inhibit Fe 3+ Ion-induced lipid peroxidation, markedly improved CCl 4 Induced liver injury in rats. Sriplang et al. found that the water extract of cat's whiskers can significantly reduce the triglyceride content in the blood plasma of diabetic rats, and significantly increase the high-density lipoprotein cholesterol conten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61P13/12A61P3/06A61P39/00A61K127/00
CPCA61K36/53A61K2236/333A61K2236/51A61P3/06A61P13/12A61P39/00
Inventor 许丛丛刘德坤蔡旋张璐
Owner QUFU NORMAL UNIV
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