Application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men

A biologically active polypeptide and fertility technology, applied in drug combinations, diseases, pharmaceutical formulations, etc., can solve problems such as unclear mechanisms of action, and achieve the goals of improving sperm function, inhibiting apoptosis, repairing pathological changes and reproductive system functions Effect
CN111110830AActive Publication Date: 2020-05-08JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2020-05-08

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Abstract

The invention discloses an application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men, and belongs to the field of damaged fertility diseases of the obesemen. The bioactive polypeptide PACAP drugs provided by the invention can significantly prevent and relieve obesity-induced male fertility damage (mainly by improving blood lipid and sex hormone levels, reducing a testicular tissue oxidative stress level, improving obesity-induced testicular spermatogenic cell damage, inhibiting high lipid-induced apoptosis of spermatogonia GC-1, and improving sperm function and early embryo quality after in-vitro fertilization), and repair pathological change and reproductive system function of fertility damage of the obese men, the relationship between obesity and male infertility can be initially understood, the protective effect of the PACAP on obesity-induced male reproductive damage can be clarified, and a theoretical basis, an experimental basis anda targeted treatment strategy are provided for clinical diagnosis and treatment of obese male infertility.
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Description

Technical field

[0001] The invention belongs to the field of obese male fertility impaired diseases, and particularly relates to the application of a biologically active polypeptide PACAP in the preparation of drugs for improving the fertility of obese men; in particular, it relates to a biologically active polypeptide PACAP in the preparation of obese male fertility impaired diseases The application of preventive, therapeutic or repairing drugs. Background technique

[0002] Obesity is a chronic metabolic disease caused by the interaction of multiple factors such as heredity, lifestyle, and environment. It is characterized by adipose tissue accumulation and systemic inflammation. Obesity is closely related to the occurrence and development of type 2 diabetes, metabolic syndrome, hypertension, cardiovascular and cerebrovascular diseases, and a variety of cancers. In addition to complications such as cardiovascular disease, obese or overweight people show that the incidence of in...

Claims

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