Application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men

A biologically active polypeptide and fertility technology, applied in drug combinations, diseases, pharmaceutical formulations, etc., can solve problems such as unclear mechanisms of action, and achieve the goals of improving sperm function, inhibiting apoptosis, repairing pathological changes and reproductive system functions Effect

Active Publication Date: 2020-05-08
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although more and more evidence shows that obesity is an important cause of male infertility, most of the current research focuses on the effects of obesity on surface phenomena such as sperm concentration, motility, morphology and serum sex hormones, and whether obesity promotes the growth of testicular germ cells. Apoptosis and the exact mechanism of action remain unclear

Method used

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  • Application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men
  • Application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men
  • Application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Select PACAP38 drugs for experimental verification (subsequently written as PACAP):

[0029] Cells and animals: GC-1 mouse testicular spermatogonia cell line (cell source: ATCC CRL-2053; cell characteristics: spermatogonia isolated from normal mouse testis, which can be subcultured in increments) for cell experiment research, selection C57 / BL6J mice (purchased from Guangdong Medical Experimental Animal Center, SPF grade) were used for animal experiment research.

[0030] (1) High-fat diet to build an obese mouse model:

[0031] The mice were randomly divided into groups and fed with standard food (Control diet, CD) and Highfat diet (HFD) for 8 weeks. The changes in body weight and food intake were monitored weekly. When the body weight of the mice in the HFD group exceeds 20% of the body weight in the CD group, it is judged that the model of obese mice is successful. Subsequently, the mice were intraperitoneally injected with different concentrations of PACAP (0.1mg / kg, 0...

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Abstract

The invention discloses an application of bioactive polypeptide PACAP in preparation of drugs for improving fertility of obese men, and belongs to the field of damaged fertility diseases of the obesemen. The bioactive polypeptide PACAP drugs provided by the invention can significantly prevent and relieve obesity-induced male fertility damage (mainly by improving blood lipid and sex hormone levels, reducing a testicular tissue oxidative stress level, improving obesity-induced testicular spermatogenic cell damage, inhibiting high lipid-induced apoptosis of spermatogonia GC-1, and improving sperm function and early embryo quality after in-vitro fertilization), and repair pathological change and reproductive system function of fertility damage of the obese men, the relationship between obesity and male infertility can be initially understood, the protective effect of the PACAP on obesity-induced male reproductive damage can be clarified, and a theoretical basis, an experimental basis anda targeted treatment strategy are provided for clinical diagnosis and treatment of obese male infertility.

Description

Technical field [0001] The invention belongs to the field of obese male fertility impaired diseases, and particularly relates to the application of a biologically active polypeptide PACAP in the preparation of drugs for improving the fertility of obese men; in particular, it relates to a biologically active polypeptide PACAP in the preparation of obese male fertility impaired diseases The application of preventive, therapeutic or repairing drugs. Background technique [0002] Obesity is a chronic metabolic disease caused by the interaction of multiple factors such as heredity, lifestyle, and environment. It is characterized by adipose tissue accumulation and systemic inflammation. Obesity is closely related to the occurrence and development of type 2 diabetes, metabolic syndrome, hypertension, cardiovascular and cerebrovascular diseases, and a variety of cancers. In addition to complications such as cardiovascular disease, obese or overweight people show that the incidence of in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P15/08
CPCA61K38/1709A61P15/08Y02A50/30
Inventor 马义洪岸
Owner JINAN UNIVERSITY
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