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Bifidobacterium longum dietary composition for intervening chronic nephritis and uremia and application

A technology of bifidobacterium longum and chronic nephritis, applied in the direction of bifidobacterium, application, drug combination, etc., can solve the problems of chronic nephritis and uremia, improve the level of inflammatory factors and uremic toxin, reduce harmful bacteria, The effect of reducing the level of oxidative stress

Pending Publication Date: 2021-04-30
BIOGROWING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have now shown that the supplementation of probiotic preparations can improve the host's antioxidant and anti-inflammatory activities, and facilitate the absorption of nutrients by the host, but there is still a lack of technology and application of probiotic-related preparations to intervene in chronic nephritis and uremia

Method used

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  • Bifidobacterium longum dietary composition for intervening chronic nephritis and uremia and application
  • Bifidobacterium longum dietary composition for intervening chronic nephritis and uremia and application
  • Bifidobacterium longum dietary composition for intervening chronic nephritis and uremia and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The prepared Bifidobacterium longum BL-G301 probiotic milk and sorghum flour extruded tablets were used as the experimental group, and the daily consumption was 100mL of probiotic milk combined with 40 g of sorghum flour extruded tablets; the control group was probiotic-free Pasteurized milk and corn flour extruded tablets, the daily consumption is 100mL of probiotic milk with 40 g corn flour extruded tablets.

[0049] Select 58 volunteers with chronic nephritis, the participants are over 18 years old, and undergo hemodialysis three to four times a week for at least three months. The personnel were randomly divided into two groups, 29 in each of the experimental group and the control group.

[0050] Blood samples were collected by qualified professionals prior to hemodialysis, centrifuged and immediately stored at -80°C.

[0051] The enzyme activity of superoxide dismutase (SOD), malondialdehyde (MDA) and total antioxidant capacity (TAC) in the samples were detected. ...

Embodiment 2

[0054] The prepared bifidobacterium longum BL-G301 probiotic milk and sorghum flour extruded tablets were used as the dietary combination of the experimental group, and the daily consumption was 100mL of probiotic milk combined with 40 g of sorghum flour extruded tablets; the control group did not contain probiotics Pasteurized milk and cornmeal extruded tablets with probiotics, 100mL probiotic milk with 40g cornmeal extruded tablets per day.

[0055] Select 58 volunteers with chronic nephritis, the participants are over 18 years old, and undergo hemodialysis three to four times a week for at least three months. The personnel were randomly divided into two groups, 29 in each of the experimental group and the control group.

[0056] Blood samples were collected by qualified professionals prior to hemodialysis, centrifuged and immediately stored at -80°C.

[0057] The concentration of IL-6, IL-10 and TNF-α, which can reflect the concentration of inflammatory factors, and the co...

Embodiment 3

[0061] The prepared bifidobacterium longum BL-G301 probiotic milk and sorghum flour extruded tablets were used as the dietary combination of the experimental group, and the daily consumption was 100mL of probiotic milk combined with 40 g of sorghum flour extruded tablets; the control group did not contain probiotics Pasteurized milk and cornmeal extruded tablets with probiotics, 100mL probiotic milk with 40g cornmeal extruded tablets per day.

[0062] Select 58 volunteers with chronic nephritis, the participants are over 18 years old, and undergo hemodialysis three to four times a week for at least three months. The personnel were randomly divided into two groups, 29 in each of the experimental group and the control group.

[0063] Blood samples were collected by qualified professionals prior to hemodialysis, centrifuged and immediately stored at -80°C.

[0064] Three indicators representing the degree of uremia in the detection sample: serum indole sulfate, p-cresol sulfate ...

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Abstract

The invention relates to the field of health-care food, in particular to a bifidobacterium longum dietary composition for intervening chronic nephritis and uremia and the application thereof. The bifidobacterium longum dietary composition comprises 100mL of bifidobacterium longum BLG301 probiotic milk and 40g of cereal powder tablets. The preparation method comprises the following steps: taking out probiotic powder frozen and preserved at -80 DEG C, cooling to room temperature, adding the probiotic powder into the pasteurized cow milk; the product prepared by the preparation method of the bifidobacterium longum BLG301 probiotic cow milk and cereal powder tablets are jointly used as diet collocation, so that oxidative stress in intestinal tracts of human bodies is improved, and the levels of inflammatory factors and urotoxin in the human bodies are reduced. Compared with the prior art, the probiotics are adopted to intervene chronic nephritis, so that the oxidative stress level of patients with chronic nephritis can be reduced; the inflammatory factor level and the uremic toxin level of a chronic nephritis patient are improved; the pH value of the excrement is improved, the organic acid content of the excrement is increased, intestinal flora is healthier, beneficial bacteria are increased, harmful bacteria are reduced, and the flora structure is more beneficial to intestinal health.

Description

technical field [0001] The invention relates to the field of health food, in particular to a bifidobacterium longum dietary combination for intervening chronic nephritis and uremia and its application. Background technique [0002] Based on incidence and prevalence, chronic nephritis has become a major public health problem worldwide, with an increase in the prevalence of chronic nephritis of approximately 5% over the past 4 years, bringing the overall average prevalence of the disease to 13.4% . [0003] Chronic nephritis promotes the accumulation of organic residues in the body, which can lead to a series of negative effects on the body, including exacerbation of inflammatory state, oxidative stress, cardiovascular dysfunction and risk of death. At present, there is no good drug control method for chronic nephritis. In order to control this accumulation, individuals with chronic nephritis generally restrict the intake of certain food groups, such as fruits, vegetables and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/123A23L7/10A23L33/00A23P10/28A61K35/745A61P13/12C12N1/20C12N1/04C12R1/01
CPCA23C9/1234A23L7/10A23L33/00A23P10/28A61K35/745A61P13/12C12N1/20C12N1/04A23V2002/00A23V2400/533A23V2200/30
Inventor 宋锦安
Owner BIOGROWING CO LTD
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