A sleep-aid sublingual spray formulation containing the active ingredient of Basang pills and its preparation method.

By using supercritical carbon dioxide extraction, gradient alcohol extraction, and macroporous adsorption resin purification processes, multiple active ingredients are extracted from Basang pills. Combined with Western sleep-aiding ingredients, this solves the problems of slow onset and low bioavailability of traditional Basang pills, achieving a rapid and highly effective sleep aid effect.

CN122075628APending Publication Date: 2026-05-26QINGDAO HISER MEDICAL CENTER
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Patent Information

Application Number
CN202610482231.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-13
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

Existing sleep aids suffer from slow onset of action, significant first-pass effect in the liver, and low bioavailability. The combined use of traditional Chinese medicine and Western medicine ingredients lacks effective modern extraction technology, making it difficult to achieve synergistic effects.

Method used

The process combines supercritical carbon dioxide extraction, gradient alcohol extraction, and macroporous adsorption resin purification to extract volatile oils, polyphenols, flavonoids, and saponins from Basang pills. These active ingredients are then combined with Western sleep aids such as melatonin, γ-aminobutyric acid, or L-theanine to form a multi-target synergistic effect.

Benefits of technology

It achieves a synergistic effect between the active ingredients of Basang Pills and Western-style sleep-aiding ingredients, resulting in rapid onset of action, improved bioavailability, and significantly enhanced sleep-aiding effect.

✦ Generated by Eureka AI based on patent content.

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Abstract

This application relates to a sublingual spray formulation containing the active ingredients of Basang Pill and its preparation method, belonging to the field of pharmaceutical technology. The sublingual spray formulation containing the active ingredients of Basang Pill provided by this application includes the active ingredients, which consist of Basang Pill extract and a Western-style sleep-aiding ingredient, with a weight ratio of (20~1):2. The Western-style sleep-aiding ingredient is selected from one or more of melatonin, γ-aminobutyric acid, and L-theanine. The Basang Pill extract is obtained from a traditional Chinese medicine composition including Terminalia chebula, Terminalia chebula, Phyllanthus emblica, Polygonatum sibiricum, Asparagus cochinchinensis, Celery scabra, Tribulus terrestris, and Mirabilis jalapa. This application achieves a synergistic effect by scientifically combining the Basang Pill extract with the Western-style sleep-aiding ingredient, realizing a new use for an old drug and providing a solution for insomnia patients with rapid onset and high bioavailability.
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