Fullerol-loaded polycaprolactone nerve scaffold and preparation method thereof

Abstract

The invention relates to a preparation method of a polycaprolactone nerve scaffold loaded with fullerol. The method comprises the following steps: uniformly mixing a polycaprolactone solution and a fullerol solution, and injecting the mixture into an electrostatic spinning device to prepare a fullerol-loaded polycaprolactone electrospun film; then preparing the polycaprolactone electrospun film loaded with fullerol into a hollow tubular stent with the wall thickness of 0.4-1.2 mm, and forming a plurality of through holes with the diameter of 10-30 [mu] m in the tube wall, thereby obtaining the polycaprolactone nerve stent loaded with fullerol. The inner diameter of the polycaprolactone nerve scaffold loaded with fullerol is 1.5 mm to 7 mm, and the length of the polycaprolactone nerve scaffold loaded with fullerol is 2 cm to 3 cm. The preparation method is simple, the size is controllable, and the material requirement is low; the polycaprolactone nerve scaffold disclosed by the invention can simulate an extracellular matrix structure, reduce the oxidative stress level in a peripheral nerve injury repair process and promote peripheral nerve regeneration; meanwhile, the mechanical strength can be increased, the degradation time can be prolonged, and nutrition exchange between defective peripheral nerves and peripheral tissues outside the tube wall is facilitated.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a polycaprolactone nerve scaffold loaded with fullerol and a preparation method thereof. Background technique [0002] Peripheral nerve injury is a common clinical injury. According to incomplete statistics, about 20 million people in my country are currently suffering from sensory dysfunction such as limb numbness and pain caused by peripheral nerve injury, and even motor dysfunction such as deformity and disability. Peripheral nerve injury seriously affects the quality of life of patients, and brings a huge burden to the patient's family and society. [0003] At present, the gold standard for the treatment of peripheral nerve injury is "autologous nerve transplantation", but it has great limitations: on the one hand, the source of autologous nerves is limited, and autologous nerve transplantation will inevitably cause dysfunction of the nerve donor site; , Due to ...

AI Technical Summary

Problems solved by technology

[0003] At present, the gold standard for the treatment of peripheral nerve injuries is "autologous nerve transplantation", but it has great limitations: on the one hand, the source of autologous nerves is limited, and autologous nerve transplantation will inevitably cause dysfunction in the nerve donor area; on the other hand, , due to the limitations of surgical suturing techniques, both adventitial sutures and perineural sutures will produce bruises, causing dysfunction

Although the nerve conduits currently used in the repair of peripheral nerve injuries can provide some mechanical support for nerve regeneration, they cannot solve the oxidative stress in the process of nerve cell repair, so they are not effective in repairing severe peripheral nerve injuries

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