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Application of Salidroside in Preventing Radiation Injury of Salivary Gland

A technology for radiation damage and salidroside, which is applied in the field of medicine and health to achieve the effects of preventing radiation damage, reducing the level of oxidative stress and improving cell survival.

Active Publication Date: 2022-05-17
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the advancement of radiotherapy technology, the degree of salivary gland radiation damage has been alleviated, and clinicians are also seeking some other means to protect the function of salivary glands, such as the application of artificial saliva, the development of salivary gland transplantation, etc., but these The method did not fundamentally change the decline in salivary gland function after radiation, so it is very important to explore new strategies to reduce the radiation damage of salivary glands and promote the repair of salivary glands after injury

Method used

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  • Application of Salidroside in Preventing Radiation Injury of Salivary Gland
  • Application of Salidroside in Preventing Radiation Injury of Salivary Gland
  • Application of Salidroside in Preventing Radiation Injury of Salivary Gland

Examples

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Effect test

Embodiment 1

[0024] Example 1: Experimental research on the prevention of radiation injury of rat submandibular gland cells by Sal

[0025] 1. Purpose

[0026] To investigate the preventive effect of Sal on radiation injury of rat submandibular gland cells.

[0027] 2. Materials and methods

[0028] In this embodiment, rat submandibular gland SMG-C6 cells were randomly divided into blank group (Control), simple Sal group (Sal), simple radiation group (IR) and Sal pretreatment group (Sal+IR). 15GyX-ray irradiation by X-ray irradiator (before irradiation, Sal intervention group (Sal alone group and Sal pretreatment group before radiation) were pretreated with 10 μS Sal for 24 hours, and the control group (blank group and radiation group) were only given the same volume (1) Pretreatment with a dose of 10 μM Sal for 24 hours, morphological observation under an inverted phase-contrast microscope 48 hours after irradiation, and cell viability detected with a CCK-8 cell viability assay kit; (2)...

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Abstract

The invention discloses the use of salidroside in preventing salivary gland radiation damage, and belongs to the field of medicine and health. The present invention finally clarifies that Sal can effectively prevent salivary gland radiation damage through cell experiments. The Sal in the present invention can be prepared as a medicine for preventing salivary gland radiation damage, which provides a new method for clinical treatment of radiation salivary gland damage.

Description

technical field [0001] The invention relates to the use of salidroside in preventing radiation damage to salivary glands, and belongs to the field of medicine and health. Background technique [0002] Salidroside (Sal), the main component of the traditional Chinese medicine Rhodiola rosea, has significant antioxidant effects and various pharmacological effects. [0003] In clinical practice, Sal has a significant clinical effect on cardiovascular and cerebrovascular diseases, and has a good protective effect on acute cerebral infarction, angina pectoris, heart failure, acute myocardial infarction and altitude sickness. At present, the existing patent CN103750143A (China) describes that Rhodiola rosea can be used to treat diseases such as coronary heart disease, angina pectoris, cerebral arterial insufficiency and hyperlipidemia. Patent CN103857400A (China) describes the application of rhodiola rosea extract in neuropathic and neurodegenerative diseases, and clarifies that r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61P39/00A61P17/16A61P39/06
CPCA61K31/7032A61P39/00A61P17/16A61P39/06
Inventor 向彬孙月美王馨悦周新茹
Owner THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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