Automatic preparation method and device for <18>F-(2S,4R)-4-fluoro-L-glutamine

Abstract

The invention relates to an automatic preparation method and device for <18>F-(2S,4R)-4-fluoro-L-glutamine. The method comprises the following steps: (1) capturing fluorinating reagent <18>F<->; (2 ) preparing <18>F<-> with nucleophilic reactivity; (3) carrying out a fluorination reaction; (4) purifying an intermediate; (5) carrying out an intermediate deprotection reaction; (6) carrying out purification and preparation of a product, wherein allowing a crude product solution obtained in the step (5) to pass a purification and preparation unit to prepare a <18>F-(2S,4R)-4-fluoro-L-glutamine product solution. Through the adoption of the automatic preparation method and device for <18>F-(2S,4R)-4-fluoro-L-glutamine, automatic preparation of <18>F-(2S,4R)-4-fluoro-L-glutamine is realized, the preparation efficiency and the stability are improved, meanwhile, an operator is protected from radiation damage, and the foundation is laid for clinical application of <18>F-(2S,4R)-4-fluoro-L-glutamine as a new metabolic imaging agent.

Description

technical field [0001] The invention relates to a method and device for automatic labeling preparation and purification of positron emission tomography (PET) drugs, in particular to a 18 An automatic preparation method and device for F-(2S,4R)-4-fluoro-L-glutamine [(2S,4R)-2,5-diamino-4-fluoro-5-oxopentanoic acid]. Background technique [0002] Positron emission tomography (PET) is an imaging method that has been widely used in clinical practice. Disease diagnosis and research. Positron drugs are the key to the function of PET. These drugs are labeled with medical positron nuclides and can participate in specific physiological processes or bind to specific targets after entering the human body. [0003] The most widely used radiopharmaceutical is 2- 18 F-2-deoxy-D-glucose ([ 18 F]FDG), mainly used for tumor diagnosis, classification and curative effect evaluation. In clinical application, it was found that some tumors [ 18 F] FDG-PET imaging was negative, suggesting th...

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Problems solved by technology

But if used for 18 The preparation of F-(2S,4R)-4-FGln still has the following problems: First, it has not yet developed a 18 F-(2S,4R)-4-FGln prepared special-purpose disposable tubing and ferrule; second, the materials used in disposable tubing have poor corrosion resistance and are not easy to contact organic acids such as trifluoroacetic acid; 3. There is no waste gas treatment device for volatile organic acids, and the use of organic acids such as trifluoroacetic acid will cause the device to be corroded

The advantage of this device is that it adopts a pinch-type solenoid valve, so that the preparation reagents flow in the pipeline, avoiding the residue in the valve body and the corrosion of the valve body; the disadvantage is that there is no tail gas treatment system, and the use of volatile organic acids will cause cause corrosion of the device, so the BNUF-A2 type cannot be applied to 18 Preparation of F-(2S,4R)-4-FGln

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