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Compositions comprising dietary fat complexer and methods for their use

Incorporating α-cyclodextrin into fat-containing products to form complexes that reduce fat bioavailability addresses the limitations of existing weight management methods, achieving effective weight loss and health benefits while preserving taste and caloric content.

Inactive Publication Date: 2012-01-24
SOHO FLORDIS INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The use of α-cyclodextrin in fat-containing products effectively reduces fat absorption, leading to weight loss, increased HDL levels, decreased triglycerides, and improved insulin resistance without adverse side effects, while maintaining the palatability and caloric content of the food products.

Problems solved by technology

If this were the case it would be difficult to imagine being able to feed enough α-cyclodextrin to an animal to complex sufficient amounts of triglycerides to make a significant difference in body weight.

Method used

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  • Compositions comprising dietary fat complexer and methods for their use
  • Compositions comprising dietary fat complexer and methods for their use
  • Compositions comprising dietary fat complexer and methods for their use

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0072]FIGS. 9A-9C depict the results of an in vitro study of vegetable oil (4 g), water (6 g) (with added food coloring for contrast) and varying amounts of (A) α-cyclodextrin (100-2,000 mg, right to left), (B) β-cyclodextrin or (C) γ-cyclodextrin. A band of “wax-like” material layered between the oil and aqueous phases is apparent in the tubes. The size of this band increases with increasing amounts of α-cyclodextrin to a maximum in the tube labeled 10% (400 mg α-cyclodextrin / 4 g oil). Note the increasing size (right to left) of a white layer of un-reacted α-cyclodextrin in the bottom of the tubes. This material is displaced from solution by either the oil or the α-cyclodextrin-oil complex. These tubes were centrifuged in order to improve the definition of the layers. The “wax-like” complex is of such a consistency that all of the tubes in 9A except for the furthest two to the right can be inverted without leakage of the aqueous phase around the complex.

[0073]The pore size of α-cyc...

example 2

Animal Studies

[0074]To examine the effect of α-cyclodextrin on body weight gain and plasma lipid levels in animals fed high fat and low fat diets, we conducted a short-term feeding study using Wistar rats. Forty-two male Wistar rats, 10 weeks old, were obtained from Harlan-Sprague Dawley. Following a one-week adaptation while being fed the control low fat diet (LF), they were divided equally into two groups, one low-fat (LF) diet and the other high-fat (HF) diet. These two groups were further divided into two subgroups. Two groups were fed the LF or HF diet and served as controls for the other two test groups which were fed the LF or HF diet containing α-cyclodextrin, wherein the amount of α-cyclodextrin was such that the ratio of α-cyclodextrin to fat in the food was 1:10 w / w. The LF diet was formulated according to AIN-93M diet and contains 4% (w / w) soybean oil as the fat source. The HF diet was a modification of the LF diet with 40% soybean oil. Therefore, the LF group receiving ...

example 3

Initial Clinical Data

Effect of α-Cyclodextrin on Serum Triglyceride Levels

[0087]To determine the effect of α-cyclodextrin on triglyceride levels, eight volunteers were fed on two consecutive days a two-egg cheese (54 g) omelet and a milkshake containing a total of 47 g of fat after an overnight fast. On the first day the meal also contained approximately 5 g of α-cyclodextrin. Blood samples (10 ml) from each volunteer taken via an in-dwelling venous catheter immediately prior the meal (zero-time) and at 1, 2 and 3 hours after the meal was consumed and were assayed for serum triglyceride levels. The zero-time sample were used as the baseline to calculate the percentage change in blood serum triglyceride levels of the human volunteers at one, two and three hours. FIG. 7 illustrates the data collected from the volunteers. It is of note that the expected increase in serum triglyceride levels is less when the α-cyclodextrin was mixed with the food than when it is not present, although th...

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Abstract

This invention relates to fat containing consumable food products comprising α-cyclodextrin. The food products have reduced levels of bioavailable fat but have substantially the same fat, cholesterol and caloric content as a like food without α-cyclodextrin. The invention also relates to methods for reducing the bioavailability of fats in fat containing food products without reducing caloric intake as determined by bomb calorimetry and to methods for increasing high density lipoproteins in a subject and reducing or controlling weight by administering the food products of this invention.

Description

[0001]This application is a continuation of U.S. application Ser. No. 10 / 628,475 filed Jul. 29, 2003 now U.S. Pat. No. 6,890,549 which claims priority to U.S. provisional patent applications Ser. No. 60 / 486,440 filed Jul. 14, 2003, Ser. No. 60 / 461,847 filed Apr. 11, 2003 and Ser. No. 60 / 404,366 filed Aug. 19, 2002 all incorporated herein in their entirety.FIELD OF THE INVENTION[0002]This invention relates to consumable products, particularly fat-containing consumable products, comprising α-cyclodextrin and methods of their use. The invention also relates to methods of reducing the bioavailability of fats in fat containing consumable products and to methods for enhancing organoleptic properties of fat containing consumable products.BACKGROUND OF THE INVENTION[0003]Efforts to control body weight through diet, exercise and drugs have met with only limited success. Obesity continues to be of epidemic proportions in the USA. It was estimated that in 2000, more than 64.5% of the US adult ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): A61K47/00A23D7/00A21D2/18A21D13/08A23K1/16A23K1/18A23L1/00A23L1/09A23L1/164A23L1/30A23L5/20A23L7/10A23L7/109A23L9/10A23L13/00A23L15/00A23L19/00A23L25/10A23L27/00A23L29/00A23L29/20A23L33/20A23P30/40A61KA61K31/724A61P1/12A61P1/14A61P1/16A61P3/02A61P3/04A61P3/06A61P3/08A61P3/10C08B37/16
CPCA21D2/181A23L1/22091A21D13/08A23K1/1643A23K1/1846A23L1/0029A23L1/0097A23L1/0156A23L1/095A23L1/1613A23L1/1643A23L1/1875A23L1/307A23L1/3212A23L1/38A61K31/724A21D2/186A23K20/163A23K50/40A23P10/30A23P30/40A23L5/273A23L29/35A23L7/111A23L7/126A23L9/12A23L27/88A23L33/20A23L15/30A23L25/10A21D13/80A61P1/00A61P1/12A61P1/14A61P1/16A61P3/00A61P3/02A61P3/04A61P3/06A61P3/08A61P43/00A61P5/50A61P3/10A61K47/40
Inventor ARTISA, JOSEPH DJEN, CATHERINE
Owner SOHO FLORDIS INT
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