Indocyanine green stabilized CuET nanoparticles, nanoparticle dispersions, their preparation methods and applications

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By using an indocyanine green-stabilized CuET nanoparticle dispersion, the problems of poor water solubility of CuET and limited photodynamic activity of indocyanine green were solved, enabling intravenous administration of CuET and enhanced antitumor therapeutic effects.

CN117357509BActive Publication Date: 2026-04-03HUAZHONG UNIV OF SCI & TECH

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Patent Information

Application Number: CN202311293458.6
Authority / Receiving Office: CN · China
Patent Type: Patents(China)
Current Assignee / Owner
Filing Date: 2023-09-28
Publication Date: 2026-04-03
Estimated Expiration: 2043-09-28

Application Information

Patent Timeline

28 Sep 2023

Application

CN202311293458.6

03 Apr 2026

Publication

CN117357509B

IPC: A61K31/325; A61K41/00; A61P35/00

CPC: A61K31/325; A61K41/0057; A61P35/00; A61K2300/00

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Application Domain

Organic active ingredients Photodynamic therapy

Technical Efficacy Phrases

Enhance photodynamic anti-tumor effectGood dispersion

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AI Technical Summary

Technical Problem

CuET has poor water solubility, making it difficult to prepare intravenous formulations in a simple and safe manner. Furthermore, the photodynamic effect of indocyanine green is limited by the hypoxic environment of tumors.

Method used

Indocyanine green-stabilized CuET nanoparticles are used, and CuET nanocrystals are combined through hydrophobic interactions to form a nanoparticle dispersion. The photodynamic effect of indocyanine green is then utilized to enhance anti-tumor therapy.

Benefits of technology

It improved the dispersibility of CuET in water and its serum stability, enhanced its killing effect on tumor cells, and improved the photodynamic antitumor effect of indocyanine green.

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Abstract

This invention belongs to the field of nanomaterials technology, and more specifically, relates to indocyanine green-stabilized CuET nanoparticles, a nanoparticle dispersion, a preparation method thereof, and its applications. The indocyanine green-stabilized CuET nanoparticles provided by this invention are nanoparticles formed by stabilizing CuET nanocrystals with indocyanine green, wherein indocyanine green binds to and stabilizes the CuET nanocrystals through hydrophobic interactions, forming the indocyanine green-stabilized CuET nanoparticles. The indocyanine green-stabilized CuET nanoparticles provided by this invention can improve the water solubility and serum stability of CuET, facilitating intravenous administration of CuET. Furthermore, the indocyanine green-stabilized CuET nanoparticles provided by this invention can disrupt mitochondrial function of tumor cells, inhibit tumor cell respiration, improve hypoxia at the tumor site, and enhance the photodynamic antitumor therapeutic effect mediated by indocyanine green.

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