Anti-cancer drug composition and preparation method thereof

An anti-cancer drug and composition technology, applied in the directions of drug combinations, biochemical equipment and methods, anti-tumor drugs, etc., can solve the problems of unavoidable chills and high fever, poor curative effect, fever, etc., and achieve the effect of improving the anti-cancer effect.

Inactive Publication Date: 2012-10-03
张炳团
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing problems include: 1. Chills and fever; 2. Poor curative effect when used alone; 3. Sensitization
Moreover, the persistent chills and high fever caused by the neurotoxic reaction of a large number of viruses to the body cannot be avoided.

Method used

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  • Anti-cancer drug composition and preparation method thereof
  • Anti-cancer drug composition and preparation method thereof
  • Anti-cancer drug composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] A dual biological anti-cancer freeze-dried powder, composed of active ingredients and protective agents, the active ingredients in each bottle are composed of NDV and NA, and the activity of NDV is 10 6 PFU / ml, the activity of NA is 0.01u / ml; each bottle of protective agent is composed of the following components by weight percentage: gelatin 1%, monosodium glutamate 1%, human albumin 1%, sucrose 10%, urea 0.5% and L-Arginine 0.2%.

[0059] The double biological anticancer freeze-dried powder is prepared by the following specific method:

[0060] 1. Chicken Newcastle Disease Virus (NDV): Preparation method and assay

[0061] (1) Selection and cultivation of primary chicken Newcastle disease virus

[0062] First select the diseased chickens with respiratory disorder, accompanied by rales, wheezing and coughing, depression, collapse and severe diarrhea, and green excrement. Then, isolate Newcastle disease virus from respiratory secretions or lung tissue of sick chicken...

Embodiment 2

[0235] A dual biological anti-cancer freeze-dried powder, composed of active ingredients and protective agents, the active ingredients in each bottle are NDV and NA, wherein the NDV activity is 10 7 PFU / ml, NA activity is 0.02u / ml; each bottle of protective agent is composed of the following components by weight percentage: 1% gelatin, 1% monosodium glutamate, 1% human albumin, 10% sucrose, 0.5% urea and L - Arginine 0.2%.

[0236] In its preparation method, except that the two ratios are different during the preparation of NDV and NA suspension, the others are roughly the same as in Example 1.

[0237] Application effect test

[0238] I. Intratumoral injection of the preparation of the embodiment of the present invention 1 to the effect test of tumor model tumor inhibition rate

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PUM

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Abstract

The invention relates to an anti-cancer drug composition. The anti-cancer drug composition comprises active ingredients: NDV (Newcastle Disease Virus) particles and NA (neuraminidase), and the activity of NDV is 10<6>-10<7> PFU/ml, and the activity of NA is 0.01-0.02u/ml. The anti-cancer drug composition has the advantages of wide anti-tumor spectrum, and obvious therapeutic effect, no obvious toxic or side effect, immunization, and direct killing effect on cancer cells. The invention further provides a preparation method of the anti-cancer drug composition.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to an anticancer pharmaceutical composition and a preparation method thereof. Background technique [0002] Tumors, especially malignant tumors, the most important methods of treatment include surgery, radiotherapy and chemotherapy, but the curative effect of these methods is not satisfactory at present. First, local treatment is not thorough and easy to relapse; Reduced immune function of the body. Simultaneously, the wound of these treatment methods is big, and toxic side effect is big, and patient is difficult to accept. [0003] In recent decades, due to the development of immunology and other related disciplines, tumor immunotherapy methods have emerged. But there is no uniform standard, there are many methods, little experience, and the curative effect varies greatly. However, the biggest advantage of immunotherapy is that it can prevent or reverse the immunosuppression cause...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K9/19A61K47/42C12N7/01A61P35/00A61K35/76
Inventor 张炳团
Owner 张炳团
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