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Ent-abieta diterpenoid largeleaf rabdosia leaf I and J, preparation method and use thereof

A technology of big-leaf fragrant tea and abietane, which is applied in the field of medicine to achieve obvious anti-tumor effect

Inactive Publication Date: 2009-04-01
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Abstract
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Problems solved by technology

[0005] But, two kinds of enantio-abietane type diterpenoids in the present invention are new compounds that are isolated and extracted for the first time from Fragrant tea, and there is no report in other natural materials, and there is no information about Enantio-abietane-type diterpene compounds, terpene, decyl, and any reports on their pharmacological activities, and experiments have proved that these two compounds have obvious tumor cell inhibitory activity, and can be used in the preparation of drugs for the treatment of cancer / tumor middle application

Method used

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  • Ent-abieta diterpenoid largeleaf rabdosia leaf I and J, preparation method and use thereof
  • Ent-abieta diterpenoid largeleaf rabdosia leaf I and J, preparation method and use thereof
  • Ent-abieta diterpenoid largeleaf rabdosia leaf I and J, preparation method and use thereof

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Embodiment Construction

[0023] The present invention will be further described below in conjunction with the examples, but the present invention is not limited thereto.

[0024] 1 H-NMR was measured with a Varian Inova 600 instrument; MS (ESIMS and HRESIMS) was measured with a Q-TOF Micro LC-MS-MS mass spectrometer; the silica gel used was produced by Qingdao Ocean Chemical Factory; various solvents were produced by Sinopharm Produced by Group Reagent Co., Ltd., all are analytically pure.

[0025] Unless otherwise specified, the liquid / liquid ratios involved in the following examples are all volume percentages or volume ratios.

[0026] Preparation Example

[0027] Preparation of enantio-abietane-type diterpenoids and decanone

[0028] (1) Extraction: The dry weight of Dayexiangcha dish is 2kg, extract by percolating with 95% ethanol (5L) at room temperature for 3 times, the extracts are combined and then concentrated under reduced pressure, the obtained crude extract is suspended in 500ml 1N NaCl...

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Abstract

The invention relates to corydalis and corydalis of isodon macrophylla which are extracted and separated from the isodon macrophylla and have the structural formula of ent-abietane diterpenoids, a preparation method and applications thereof. A plurality of in vitro anti-tumor activity experiments show that the compounds have significant effect of inhibiting the activity of tumor cells and can be applied in the preparation of medicaments for treating cancers and / or tumors. The invention can also provide the lead compounds for developing new medicaments for treating various common multiple cancers, thereby having important significance on developing and utilizing medicinal plant resources of China.

Description

technical field [0001] The present invention relates to the field of medical technology, in particular to enantio-abietane-type diterpene compounds macrophynin E, decane (macrophynin E, F) isolated from Chinese macrophynin and its preparation method and application . The above-mentioned compound has strong inhibitory effect on various tumor cell lines, and can be used as a lead compound for developing new anti-tumor drugs, and can also be used as a drug for treating various common clinical multiple cancers. Background technique [0002] Isodon plants belong to the Lamiaceae (Labiatae=Lamiaceae) Ocimoideae, and are perennial herbs, shrubs, and semi-shrubs with thick, woody rhizomes that are lumpy. There are more than 150 species of plants in this genus, which are produced from southern Africa to tropical Africa (a few species), tropical and subtropical Asia, north to Japan, the Russian Far East, and a few species from Malaysia to Oceania and Pacific Islands. There are 90 sp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C39/12C07C37/68C07C62/38C07C51/42A61K31/19A61K31/05A61P35/00
Inventor 郭跃伟黄才国钦松冯波王国飞
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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