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Ginseng and bamboo leaf composition capable of preventing and treating alcoholic liver injuries

A technology of alcoholic liver injury and composition, which is applied in the fields of medicine and food, and can solve the problems of insignificant and reduced effect of cholestatic liver injury, achieve improvement of symptoms of alcoholic liver injury, reduce damage, and have high safety Effect

Inactive Publication Date: 2016-08-24
JILIN CHANGBAI MINGZHU FOREST FOOD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hou Shaozhen's research shows that the extract of Narrow Baseline Fragrant Tea can significantly reduce the serum ALT and AST levels in mice with acute alcoholism and the mortality rate of rats with chronic alcoholic fatty liver, and reduce the pathological damage of liver tissue; Bile secretion in rats, but it has no obvious effect on cholestatic liver injury (New Drugs and Clinical Pharmacology of Traditional Chinese Medicine, Volume 21, Issue 6, November 2010)

Method used

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  • Ginseng and bamboo leaf composition capable of preventing and treating alcoholic liver injuries
  • Ginseng and bamboo leaf composition capable of preventing and treating alcoholic liver injuries
  • Ginseng and bamboo leaf composition capable of preventing and treating alcoholic liver injuries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, Preparation of Total Ginsenosides

[0056]Ginseng 5kg, decocted and extracted with 10 times the amount of water for 3 times, each time for 2 hours, filtered, the filtrate was concentrated, the concentrated solution passed through the pre-treated D-101 macroporous adsorption resin column, and first eluted with deionized water 4 times the column volume, discard the eluate, and then use 70% ethanol to elute for 4 times the column volume, collect the eluate, recycle the ethanol, and dry to obtain total ginsenosides. Taking ginsenoside Re as the reference substance, the content of total ginsenosides was 86.5% as determined by ultraviolet spectrophotometry.

Embodiment 2

[0057] Example 2 , Preparation of total flavonoids

[0058] 5 kg of grape leaves, reflux extraction with 8 times the amount of 60% ethanol for 2 times, each time for 3 hours, filtered, the filtrate recovered ethanol, concentrated to 7500ml, passed through the pre-treated AB-8 macroporous resin column, first used to remove Elute with deionized water for 5 times the column volume, discard the eluent, then elute with 10% ethanol for 3 times the column volume, discard the eluent, continue to elute with 65% ethanol for 4 times the column volume, collect the eluate, Recover the ethanol and dry it to obtain the total flavonoids of the Serpentis japonicus. Taking rutin as the reference substance, the content of total flavonoids is 92.1% as determined by ultraviolet spectrophotometry.

Embodiment 3

[0059] Example 3 , preparation of total flavonoids from bamboo leaves

[0060] Phyllostachys pubescens leaves 5kg, reflux extraction 2 times with 8 times the amount of 65% ethanol, each time for 2 hours, filter, the filtrate recovers ethanol, concentrates to 5000ml, passes through the pre-treated AB-8 macroporous resin column, first deionized Elute with water for 5 times the column volume, discard the eluate, then elute with 25% ethanol for 3 times the column volume, discard the eluate, continue to elute with 75% ethanol for 4 times the column volume, collect the eluate, and recover Ethanol, dried to obtain total flavonoids of bamboo leaves. Taking rutin as the reference substance, the content of total flavonoids was 88.6% as determined by ultraviolet spectrophotometry.

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PUM

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Abstract

The invention relates to a natural medicine composition capable of preventing and treating alcoholic liver injuries. The composition is prepared from total saponins of ginsengs, total flavonoids of ampelopsis grmsedntara leaves, total flavonoids of bamboo leaves and isodon lophanthoides var.gerardianus extract. The invention further relates to application of the composition to preparation of health foods capable of preventing and treating acute and chronic alcoholic liver injuries and preparation of health foods, beverages and tea capable of preventing and treating non-alcohol fatty liver. All the components of the composition have good synergistic effect and remarkable curative effect; raw materials are easily obtained, the cost is relatively low and the practicability is relatively strong.

Description

technical field [0001] The invention belongs to the fields of medicine and food, and relates to a composition with natural products for preventing and treating related diseases such as alcoholic liver injury. Background technique [0002] Alcoholic liver damage (ALD) is a toxic liver disease caused by long-term excessive drinking, and ALD is the leading cause of liver cirrhosis in patients in Western countries. In my country, alcoholic liver disease has gradually increased in recent years, and has become the second largest cause of liver disease after viral hepatitis. Alcoholic liver disease is a liver disease caused by long-term heavy drinking. It usually manifests as fatty liver at the initial stage, and then can develop into alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis. Severe alcoholism can induce extensive liver cell necrosis or even Liver failure. Up to now, there is no ideal medicine to effectively prevent and treat the occurrence and develo...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P1/16A23L33/105A61K36/258A61K36/87A61K36/53
CPCA23V2002/00A61K36/258A61K36/53A61K36/87A61K36/899A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00A23V2200/334
Inventor 南敏伦赫玉芳赵昱玮吕娜王雪马吉胜赵全成
Owner JILIN CHANGBAI MINGZHU FOREST FOOD CO LTD
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