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Method for extracting cedrela sinensis total polyphenol

A technology of total polyphenols and Chinese toon, which is applied in the field of preparing total polyphenols of Chinese toon by membrane separation and macroporous resin, can solve the problems of low product content and low yield, and achieve remarkable effects and reduce losses

Inactive Publication Date: 2012-08-29
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The content of the product obtained by this method is low, and the yield is low, because polyphenols are easy to oxidize and decompose when concentrated at high temperature for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Shred fresh Chinese toon leaves, take 5kg, add 40kg of 40% ethanol to extract at 60°C for 2 hours, extract twice, filter the extract, add a hollow composite ultrafiltration membrane with a molecular weight cut off of 10000, and add a hollow composite ultrafiltration membrane with a molecular weight cut off of 00 to the permeate Nanofiltration membrane concentration, ultrafiltration and nanofiltration are all carried out at room temperature, the filtration pressure is controlled in the range of 0.5-0.8Mpa, the concentrated solution is further concentrated under reduced pressure to no alcohol, the process reduced pressure concentration temperature is not higher than 65 ° C, add a small amount of water to dilute , add LAS-7 macroporous resin for adsorption, wash the resin column with water without sugar color, take 5BV80% ethanol solution for elution, collect the eluent and concentrate it under reduced pressure, and freeze-dry the concentrated solution to obtain the total po...

Embodiment 2

[0017] Shred fresh Chinese toon leaves, take 5kg, add 30kg of 50% ethanol to extract at 60°C for 1 hour, extract 3 times, filter the extract, add a hollow composite ultrafiltration membrane with a molecular weight cut off of 20,000, and add a hollow composite ultrafiltration membrane with a molecular weight cut off of 300 to the permeate Nanofiltration membrane concentration, ultrafiltration and nanofiltration are all carried out at room temperature, the filtration pressure is controlled in the range of 0.5-0.8Mpa, the concentrated solution is further concentrated under reduced pressure to no alcohol, the process reduced pressure concentration temperature is not higher than 65 ° C, add a small amount of water to dilute , add ADS-21 macroporous resin for adsorption, wash the resin column with water without sugar color, take 7BV50% ethanol solution for elution, collect the eluate and concentrate it under reduced pressure, and freeze-dry the concentrated solution to obtain the tota...

Embodiment 3

[0019] Shred fresh Chinese toon leaves, take 5kg, add 40kg of 60% ethanol and extract at 50°C for 2 hours, extract twice, filter the extract, add a hollow composite ultrafiltration membrane with a molecular weight cut off of 10,000, and add a hollow composite ultrafiltration membrane with a molecular weight cut off of 200 to the permeate Nanofiltration membrane concentration, ultrafiltration and nanofiltration are all carried out at room temperature, and the filtration pressure is controlled in the range of 0.5-0.8Mpa. The concentrated solution is further concentrated under reduced pressure to no alcohol. The process reduced pressure concentration temperature is not higher than 65°C, and a small amount of water is added Dilute, add NKA-II macroporous resin for adsorption, wash the resin column with water without sugar color, take 6BV70% ethanol solution for elution, collect the eluate and concentrate it under reduced pressure until alcohol-free, and freeze-dry the concentrated s...

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PUM

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Abstract

The invention provides a method for extracting cedrela sinensis total polyphenol. The method comprises the following steps: taking fresh cedrela sinensis as a raw material; shredding; adding 6-8-fold 40-60% ethanol, preserving heat and extracting for 2-3 times; filtering an extraction solution; adding the extraction solution into an ultrafiltration membrane for filtering; adding a passing solution into a nanofiltration membrane for concentrating; further performing decompressed concentration to concentrate till no alcohol exists; adding a small amount of water for diluting; adding the diluted solution to macroporous resin for adsorbing; washing the macroporous resin column with water till no sugar color is seen; taking 5-7BV 50-80% ethanol solution for eluting; performing decompressed concentration to eluate; and freezing and drying the concentrate to obtain the cedrela sinensis total polyphenol. The cedrela sinensis total polyphenol produced by the method is high in yield and high in content; process steps are simple and easy to operate; and the method is applicable to industrial production.

Description

Technical field: [0001] The invention relates to a method for extracting total polyphenols of Chinese toon, in particular to a method for preparing total polyphenols of Chinese toon by using membrane separation and macroporous resin. Background technique: [0002] Toona sinensis is a perennial deciduous tree of the Meliaceae family, which is native to China and distributed throughout the country. It is edible with tender stems and leaves, and has high economic value. Traditional Chinese medicine believes that Toona sinensis is cool in nature, bitter in taste, and enters the lung, stomach, and large intestine meridian. Indications for sores, hair loss, red eyes, lung heat cough and other diseases. Modern studies have found that Toona sinensis leaves are rich in polyphenols, which have good antioxidant and blood lipid-lowering effects. [0003] The total polyphenols of Toona sinensis are composed of various components, including polyhydroxy flavonoid glycosides and aglycones...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/58A23L1/30A61P3/06A61P39/06
Inventor 李法庆刘东锋
Owner 苏州宝泽堂医药科技有限公司
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