4 results about "Chromosome regions" patented technology

The present application provides a marker combination for early detection of digestive system cancer, tissue localization, diagnosis, prognosis detection and identification of benign and malignant, the marker combination is selected from 1656 chromosome regions in table 1. A multi-cancer early screening and localization technology GutSeer for five high mortality digestive system cancers is also provided, which proves that using a relatively small second-generation sequencing panel can realize accurate cancer detection and organ tissue localization by using multiple dimensional characteristics including methylation, copy number variation and terminal motif.

This application provides a method and system for intelligent chromosome karyotype segmentation that integrates deep learning. The method involves: enhancing chromosome microscopic images; performing region segmentation based on the enhanced chromosome images to obtain multiple chromosome region sub-images; for any chromosome region sub-image, extracting the chromosome pixel area and band count corresponding to that sub-image, and determining the structural coverage index of the sub-image based on these values; comparing the structural coverage index with a preset chromosome banding distribution model to perform anomaly screening and identify candidate chromosome adhesion regions; and segmenting the candidate adhesion regions using a deep learning segmentation model to obtain the corresponding chromosome karyotype segmentation image. This application can screen and identify candidate adhesion regions based on the chromosome skeleton banding density, improving the accuracy of chromosome image segmentation.

This invention relates to the field of genetic engineering technology, and more particularly to a molecular marker for detecting wheat leaf rust resistance genes LrN4B or LrN3B and its application. The molecular marker LrN4B-1 is located in the 578-585Mb region of chromosome 4BL, with a polymorphism of C / G. The molecular marker LrN3B-1 is located in the 4-8Mb region of chromosome 3BS, with a polymorphism of T / C. This invention obtains molecular markers linked to wheat leaf rust resistance genes LrN4B and LrN3B through the construction of genetic linkage maps and the screening and localization of molecular markers. These two molecular markers can be used to distinguish the LrN4B+LrN3B disease-resistant genotype, screen for wheat lines containing these two disease-resistant genes, accelerate the process of wheat disease-resistant breeding, and are of great significance in the field of breeding leaf rust-resistant wheat.