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Copy number alterations that predict metastatic capability of human breast cancer

A technology for human breast cancer and prognosis, applied in the direction of biochemical equipment and methods, microbial measurement/testing, etc.

Inactive Publication Date: 2010-12-15
VERIDEX LCC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no studies using high-throughput, high-resolution platforms to examine the association of DNA copy number changes with breast cancer prognosis

Method used

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  • Copy number alterations that predict metastatic capability of human breast cancer
  • Copy number alterations that predict metastatic capability of human breast cancer
  • Copy number alterations that predict metastatic capability of human breast cancer

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Embodiment Construction

[0016] Specific DNA copy number alterations (CNAs), such as deletions and amplifications, are major genomic changes that contribute to carcinogenesis and tumor progression through decreased apoptosis, uncontrolled proliferation and increased motility and angiogenesis. Since a large proportion of genomic aberrations are not related to cancer biology but are simply caused by random neutral events, it is a challenge to identify those causative gene CNAs responsible for the regulation of gene expression ultimately leading to malignant transformation and progression . Fluorescence in situ hybridization and comparative genomic hybridization (CGH) have both revealed chromosomal regions displaying CNAs in breast tumors. In a recent study including 51 breast tumors, high-resolution SNPs were used in combination with gene expression profiling to refine breast cancer amplicon boundaries and narrow the list of potential driver genes. However, only a few studies have examined the prognost...

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Abstract

Disclosed in this specification is a method of defining chromosome regions of prognostic value by summarizing the significance of all SNPs (single nucleotide polymorphism) in a predetermined section of a chromosome to define chromosome regions of prognostic value. Based on the SNPs in specified genes, a more accurate prognosis for breast cancer may be provided.

Description

[0001] Cross references to related patent applications [0002] This application claims priority and benefit from co-pending US Provisional Patent Application Serial No. 61 / 007,650, filed December 14, 2007, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates in one embodiment to a method of providing a prognosis of breast cancer by determining the number of single nucleotide polymorphisms (SNPs) in a given gene. Background technique [0004] Breast cancer is a heterogeneous disease that exhibits a variety of clinical presentations, histologic types, and growth rates. Among patients without detectable lymph node metastases (a group considered low risk), 20-30% of patients develop recurrent disease after five to ten years of follow-up. Identification of individuals at risk of recurrence in this group cannot be reliably performed at present. [0005] DNA copy number alterations (CNAs) or copy number polymorphisms ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
CPCC12Q1/6827C12Q2600/156C12Q2600/118
Inventor Y·张J·X·于Y·蒋Y·王
Owner VERIDEX LCC
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