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2 results about "Fetal aneuploidy" patented technology
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Aneuploidy is the loss or gain of a chromosome. Instead of pairs being formed, a single chromosome ends up alone or with multiple partners. ... Aneuploidy also alters cell division and growth, and therefore fetal development, often resulting in miscarriage or severe birth defects. When germ cells exhibit aneuploidy, they give rise to certain disorders, depending on if a chromosome is missing, monosomy, or if there is an extra chromosome, trisomy.
Method for non-invasive prenatal screening using cell-free DNA extraction
This invention relates to a method for non-invasive prenatal screening using cell-free DNA extraction. Specifically, the invention provides a method and system for extracting cell-free DNA from liquid biological samples. The method can be used for determining fetal DNA fractions and for non-invasive prenatal screening of fetal aneuploidy and analysis of other types of cell-free DNA.
Owner:QUEST DIAGNOSTICS INVESTMENTS INC
Method for determining copy number variations
A method for determining copy number variations (CNV) of a sequence of interest in a test sample that comprises a mixture of nucleic acids that are known or are suspected to differ in the amount of one or more sequence of interest. The method comprises a statistical approach that accounts for accrued variability stemming from process-related, interchromosomal and inter-sequencing variability. The method is applicable to determining CNV of any fetal aneuploidy, and CNVs known or suspected to be associated with a variety of medical conditions.
Owner:VERINATA HEALTH INC