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Plasma consists of DNA released from multiple tissues within the body. Using genome-wide bisulfite sequencing of plasma DNA, we obtained a bird’s eye view of the identities and contributions of these tissues to the circulating DNA pool.
Multiplex amplification detection assay for plasma DNA and isolation and detection
The technology provided herein relates to amplification-based detection of bisulfite treated DNA, and in particular, but not exclusively, to methods and compositions for multiplex amplification of low levels of sample DNA prior to further characterization of the sample DNA. The technology also provides methods for isolating DNA from a blood or blood product sample, such as a plasma sample.
Owner:EXACT SCIENCES CORP