Immunotoxins directed against malignant cells

a technology of immunotoxins and malignant cells, applied in the direction of antibody medical ingredients, peptide/protein ingredients, peptide sources, etc., can solve the problems of stymied utilization of this type of anti-tumor therapy, undesired side effects, and traditional chemotherapies, and achieve dramatic lowering of side effects and surprising properties
US20050249738A1Inactive Publication Date: 2005-11-10THE GOVT OF THE U S A AS REPRESENTED BY THE SECT OF THE DEPT OF HEALTH & HUMAN SERVICES +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE GOVT OF THE U S A AS REPRESENTED BY THE SECT OF THE DEPT OF HEALTH & HUMAN SERVICES
Publication Date
2005-11-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to immunotoxins, that effectively kill malignant cells having a given surface marker and nucleic acid constructs encoding them. These reagents comprise a toxic moiety that is derived from a Rana pipiens protein having ribonucleolytic activity linked to an antibody capable of specific binding with a chosen tumor cell.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of and claims priority to U.S. Provisional Application 60 / 046,895, filed May 2, 1997. The disclosure of the following U.S. Provisional Patent Application is incorporated herein by reference in its entirety: S. M. Rybak and D. L. Newton, “Recombinant Anti-Tumor RNAse,” filed Mar. 27, 1998 (Attorney Docket No. 15280-343000).FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] Not applicable. BACKGROUND OF THE INVENTION

[0003] Toxic enzymes from plants and bacteria such as ricin, diphtheria toxin and Pseudomonas toxin have been coupled to antibodies or receptor binding ligands to generate cell-type-specific-killing reagents (Youle, et al., Proc. Nat'l Acad. Sci. USA 77:5483 (1980); Gilliland, et al., Proc. Nat'l Acad. Sci. USA 77:4539 (1980); Krolick, et al., Proc. Nat'l Acad. Sci. USA 77:5419 (1980)). Regardless of the fact that the cell-recognition moiety is not always an antibody, these directed toxins a...

Claims

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