Use of HIF-2 alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction

A technology of HIF-2, alpha inhibitor, applied in the field of biomedicine, can solve the problems of limited clinical efficacy, difficult promotion and application, complicated preparation process, etc., and achieves the effects of good curative effect, alleviation of emotional anxiety, and good safety.

Inactive Publication Date: 2018-12-11
DALIAN NUOYI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prior art has complex components, high cost, cumbersome preparation process, and most importantly, limited clinical curative effect, making it difficult to popularize and apply

Method used

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  • Use of HIF-2 alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction
  • Use of HIF-2 alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction
  • Use of HIF-2 alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of HIF-2α-I2 tablets, a medicine for preventing and treating acute altitude sickness

[0034] Accurately weigh 100 grams of HIF-2α-I2 monomer (purity greater than 98.5%), add 400 g of medicinal starch, and mix the two thoroughly to make 1000 tablets, each weighing 0.5 grams, containing 100 mg of HIF-2α-I2.

Embodiment 2

[0035] Example 2: Preparation of PT2385 capsules, a drug for preventing and treating acute altitude sickness

[0036] Accurately weigh 100 grams of PT2385 monomer (purity greater than 98.5%), add 400 g of medicinal starch, mix the two thoroughly, granulate with a 20-mesh sieve, dry at 60°C, and then divide and fill them into hollow capsules. Into 2000 capsules, each weighing 0.25 grams, containing PT2385 50mg.

Embodiment 3

[0037] Embodiment 3: the preparation of the pharmaceutical composition of preventing and treating acute altitude sickness

[0038] Accurately weigh 100 grams of HIF-2α-I2 monomer (purity greater than 98%), 40 grams of PT2385 monomer (purity greater than 98%), add medicinal starch 350g, and make 1000 tablets after the above ingredients are fully mixed, each weighing 0.5 grams, containing 100mg HIF-2α-I2 and 40mg PT2385.

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PUM

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Abstract

The present invention provides a use of a HIF-2alpha inhibitor in preparation of drugs for preventing and treating acute high-altitude reaction. The HIF-2alpha inhibitor comprises HIF-2alpha-I2 and/orPT2385; the use according to the invention fully investigates molecular mechanisms and key molecular events and processes of acute high-altitude reaction and hypoxia stress, and a series of experiments shows that HIF-2alpha-I2 and PT2385 both can significantly improve the malignant degree and symptoms including slowing shortness of breath, emotional upset, and high heart rate of acute high-altitude reaction, as well as alleviate the acute hypoxic stress response, so as to achieve the purpose of effectively preventing acute hypoxia. The use has good safety, little side effects and other advantages, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of HIF-2α inhibitors for preparing medicines for preventing and treating acute altitude sickness. Background technique [0002] Hypoxia is a characteristic phenomenon in the special environment of plateau, and it is also the main cause of acute mountain sickness (AMS). Acute altitude sickness (AMS) refers to a series of non-specific clinical manifestations within a few hours after people who have lived in low-altitude areas for a long time have not adapted to the new environment from the plains to areas at an altitude of 3,000 meters and above, including emotional distress. , Insomnia, headache, dizziness, chest tightness, shortness of breath, palpitations, anorexia, nausea, vomiting and a series of symptoms. Most AMS patients usually relieve their symptoms after staying at high altitude for 24-72 hours, and the symptoms gradually disappear after a few days, but a fe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/277A61K31/4245A61P39/00
CPCA61K31/277A61K31/4245A61P39/00A61K2300/00
Inventor 葛广波刘磊李康
Owner DALIAN NUOYI BIOTECH CO LTD
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