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Compound genticin-micronomicin injection, preparing method and use thereof

A technology of gentamicin sulfate and small noromycin, applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of long withdrawal period and reduced efficacy, and achieve enhanced efficacy and reduced drug resistance. , the effect of increasing relative body weight

Inactive Publication Date: 2007-08-15
TIANJIN SHENGJI GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For decades, tylosin has been listed as the first choice drug for the treatment of mycoplasma pneumonia in swine all over the world. Due to the repeated use of antibiotics for a long time, the pathogenic microorganisms have developed resistance to the drug, which has reduced the curative effect, and there is still a long period of drug withdrawal. Shortcomings

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 (every part is 500g):

[0016] Compound Qingda Sulfate-Micronomycin Injection: 3 parts of Qingda Sulfate-Micronomycin Injection, 0.2 part of Chlorpheniramine, and 0.05 part of Dexamethasone Sodium Phosphate.

[0017] Made in the following way:

[0018] (1) Take by weight 3 parts of genta sulfate-micronomycin injection, 0.2 part of chlorpheniramine, and 0.05 part of dexamethasone sodium phosphate;

[0019] (2) Take 1.65 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

Embodiment 2

[0020] Embodiment 2 (every portion is 1500g):

[0021] Compound Qingda Sulfate-Micronomycin Injection: 2 parts of Qingda Sulfate-Micronomycin Injection, 0.1 part of Chlorpheniramine, and 0.04 part of Dexamethasone Sodium Phosphate.

[0022] Made in the following way:

[0023] (1) Take 2 parts of genta sulfate-micronomycin injection, 0.1 part of chlorpheniramine, and 0.04 part of dexamethasone sodium phosphate by weight;

[0024] (2) Take 1.05 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

Embodiment 3

[0025] Embodiment 3 (every portion is 2500g):

[0026] Compound genta sulfate-minornomycin injection injection: 10 parts of genta sulfate-minornomycin injection, 0.8 parts of chlorpheniramine, and 0.5 parts of dexamethasone sodium phosphate.

[0027] Made in the following way:

[0028] (1) Take by weight 10 parts of genta sulfate-micronomycin injection, 0.8 part of chlorpheniramine, and 0.5 part of dexamethasone sodium phosphate;

[0029] (2) Take 5.45 parts of water for injection and heat it to 40-50°C; add the genta sulfate-minornomycin, chlorpheniramine, and dexamethasone sodium phosphate in sequence, stir and dissolve, and adjust the pH to 3.5 with hydrochloric acid or sodium hydroxide -6.5, add water for injection to 1000 parts and promptly make a kind of compound genta sulfate-minornomycin injection.

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PUM

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Abstract

The invention discloses an injection of compound micironomicin sulfate, its preparation method and application. the injection comprises (by weight part) micironomicin sulfate injection 1-20, chlorpheniramine maleate 0.1-1, and dexamethasone sodium phosphate 0.01-1. the preparation method comprises heating 50% water for injection to 40-50deg.C, dissolving each components, regulating pH to 3.5-6.5 with hydrochloric acid or sodium hydroxide, and adding water for injection to 1000. The invention has the advantages of rational formulation, reduced drugfastness, and shortened withholding period. It can enhance therapeutic effect, improve swinish immunity, increase swinish body weight; and can be used for treating mycoplasmal pneumonia of pig.

Description

technical field [0001] The invention relates to a drug injection, a preparation method and use, in particular to a compound genta sulfate-minornomycin injection, a preparation method and a use. Background technique [0002] Pig asthma (or swine panting), also known as mycoplasma hyopneumoniae, is a chronic respiratory infectious disease of pigs. It is one of the most common diseases in pigs. The main clinical symptoms of this disease are cough and wheezing. The pathological changes are mainly located in the chest cavity. The lung is the main organ of the disease. In acute cases, pulmonary edema and emphysema are the main diseases; And chronic cases see lung "shrimp meat" like consolidation, the growth rate of diseased pigs is slow, the feed utilization rate is low, and the fattening and rearing period is prolonged. It is easy to cause Pasteurella, pneumococcus, Actinobacillus pleuropneumoniae, Salmonella and various suppurative bacteria, Mycoplasma hyorhinophylla and Chlamy...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61K9/08A61P11/06A61K31/4402A61K31/573
Inventor 魏宗生郭建华耿强斌
Owner TIANJIN SHENGJI GRP CO LTD
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