4results about How to "Inhibition level" patented technology

The invention discloses a material for treating inflammatory skin diseases, a preparation method and application, the inflammatory skin diseases comprise psoriasis and atopic dermatitis, and the material comprises cerium substituted molybdenum-based polyoxometallate. The application has the advantages that the CMB has reliable biological safety and excellent active oxygen scavenging capacity, and can effectively inhibit the level of ROS (reactive oxygen species) in cells at lower concentration, so that the inflammation activation of psoriasis or atopic dermatitis is inhibited, and the effect of treating psoriasis or atopic dermatitis is achieved; compared with a water-insoluble inorganic nano material, the CMB material can be dissolved in water, is not easy to retain in local tissues, is more easily metabolized by an organism, and is better in safety.

This invention relates to the field of biomedical technology, and more particularly to the application of an isoflavone compound, specifically Corylifol A, in the preparation of drugs for the prevention and / or treatment of inflammatory diseases. When used to prepare drugs for the prevention and / or treatment of inflammatory diseases, this isoflavone compound can directly bind to the IκBα protein and specifically inhibit its phosphorylation, thereby blocking the phosphorylation and nuclear translocation of the NF-κB p65 subunit, ultimately inhibiting the overactivation of the NF-κB signaling pathway. Furthermore, the isoflavone compound can significantly reduce the mortality rate of lipopolysaccharide-induced septicemia in mice, inhibit the levels of inflammatory factors in serum and lung tissue, and effectively alleviate LPS-induced acute lung injury in mice. Simultaneously, when the isoflavone compound is controlled within an effective concentration range, it exhibits no significant cytotoxicity to mouse peritoneal macrophages and can significantly inhibit the production and release of lipopolysaccharide-induced inflammatory factors IL-1β, TNF-α, and IL-6.

This invention discloses the application of a Trichinella spiralis cysteine ​​protease inhibitor in acute myocardial infarction and subsequent ventricular remodeling, belonging to the field of medicinal chemistry. This invention provides a drug that can prevent, alleviate, and / or treat acute myocardial infarction and subsequent ventricular remodeling. The active ingredient of this drug is the Trichinella spiralis cysteine ​​protease inhibitor cystatin, abbreviated as rTs-Cys. rTs-Cys can effectively delay acute myocardial infarction and inflammatory response in mice, reduce the infarct area, improve cardiac function deterioration, and reverse organ pathological damage, providing a new approach for the clinical treatment of acute myocardial infarction and subsequent ventricular remodeling.

The invention provides an anti-aging and hair-toughening collagen peptide composition and a preparation method thereof, and belongs to the technical field of collagen peptides. The preparation process comprises the following steps: pretreating the raw materials; extraction and preparation of collagen peptide; preparation of the gallic acid-sodium hyaluronate grafted collagen peptide; preparing a haematococcus pluvialis composite microcapsule; pea seedling and opuntia ficus-indica-assisted bidirectional fermentation preparation; and preparing the collagen peptide composition. The composition disclosed by the invention contains gallic acid-sodium hyaluronate grafted collagen peptide, haematococcus pluvialis composite microcapsules, fermentation liquor, wheat germ powder and ginseng powder, and has anti-aging and hair-toughening effects.