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Application of oligomeric proantho cyanidins in preparing products resisting vascular dementia

A technology with low proanthocyanidins and low proanthocyanidins, which is applied in the fields of medicine, food and beverages, and can solve the problems of anti-vascular dementia products of proanthocyanidins compounds and anti-vascular dementia products of proanthocyanidins compounds, etc., so as to reduce economic pressure and monitor burden, significant social benefits, and the effect of improving the quality of life

Inactive Publication Date: 2010-12-29
ZHEJIANG XIAOSHAN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0108] However, through literature search, so far, no report on the application of proanthocyanidins as an anti-vascular dementia product has been found;

Method used

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  • Application of oligomeric proantho cyanidins in preparing products resisting vascular dementia
  • Application of oligomeric proantho cyanidins in preparing products resisting vascular dementia
  • Application of oligomeric proantho cyanidins in preparing products resisting vascular dementia

Examples

Experimental program
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preparation example Construction

[0248] The preparation method of proanthocyanidins is a mature method, which has been published in various journals and patent documents, and will not be repeated in the present invention.

[0249] In the present invention, the specific implementation manners described above and the examples described below are for better illustrating the present invention, and are not used to limit the scope of the invention.

Embodiment 1

[0251] Embodiment 1, the preparation of proanthocyanidin tablet

[0252] prescription:

[0253] Proanthocyanidins 150g

[0254] Starch 80g

[0255] Lactose 20g

[0256] Sodium carboxymethyl starch 10g

[0257] Appropriate amount of starch slurry (7%)

[0258] Magnesium Stearate 1%

[0259] Made into 1000 pieces

[0260] Process:

[0261] Pass the proanthocyanidins through an 80-mesh sieve, mix with starch, lactose, and sodium carboxymethyl starch, and add starch slurry to make soft materials. Granulate through a 16-mesh sieve, dry below 60°C, granulate, add magnesium stearate, mix well, and compress into tablets. Can be made into 1000 tablets each containing 150mg proanthocyanidins.

Embodiment 2

[0262] Embodiment 2, the preparation of proanthocyanidin capsules

[0263] prescription:

[0264] Proanthocyanidins 150g

[0265] Starch 40g

[0266] Micronized silica gel 10g

[0267] Make 1000 capsules

[0268] Process:

[0269] The proanthocyanidins pass through a 80-mesh sieve, mix with the prescribed amount of starch and micropowder silica gel, and directly pack into capsules to make capsules containing 150mg of proanthocyanidins each.

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Abstract

The invention relates to application of oligomeric proantho cyanidins in preparing products for preventing, diagnosing, detecting, protecting, treating and studying vascular dementia and directly related diseases thereof, in particular to new application in medicament and health-care products. Experiments prove that oligomeric proantho cyanidins can improve the study memory ability of a heart andbrain ischemia-reperfusion mouse and a permanent bilateral common carotid arteries rat, inhibit lipid peroxidation in brains of the heart and brain ischemia-reperfusion mouse and the permanent bilateral common carotid arteries rat, and improve the superoxide dismutase enzyme activity of the heart and brain ischemia-reperfusion mouse and the permanent bilateral common carotid arteries rat. The oligomeric proantho cyanidins have strong action, clear effect, rich resource, simple preparation process, high yield, stable property and safe use, in particular one object with multiple functions and wide application range, and can play roles furthest. Disease rate of dementia rises gradually, after popularization, the application of oligomeric proantho cyanidins can generate significant social benefit and economic benefit in short time.

Description

technical field [0001] The invention relates to the technical fields of medicine, food and beverage, in particular to the use of traditional Chinese medicine extracts, and more specifically to the use of proanthocyanidins in the preparation of anti-vascular dementia products. Background technique [0002] (1) Research overview of proanthocyanidins [0003] 1 Overview [0004] Proanthocyanidins (Oligomeric Proantho Cyanidins, referred to as: OPCs or OPC), also known as concentrated genes (Pycnjogenols), is a bioflavonoid with a special molecular structure, is a high-efficiency cofactor, is currently recognized internationally, the most active It is the most effective natural antioxidant, scavenging free radicals and its anti-aging substances. It is generally a reddish-brown powder with a slight gas and astringent taste, soluble in water and most organic solvents. Typically grape seed extract or French maritime pine bark extract. [0005] Proanthocyanidins are a new type o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A61P25/28A23L1/30A23L33/105
Inventor 蒋国军李铁军邱彦商炜炜张建军伊佳
Owner ZHEJIANG XIAOSHAN HOSPITAL
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