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Use of 2-mercapto-3-butanol in preparation of anti-lenticular opacity products

A lens and application technology, applied in the fields of medicine, food, beverages and reagents, can solve the problems such as undiscovered 2-mercapto-3-butanol anti-lens turbidity products, low efficiency, large side effects, etc.

Inactive Publication Date: 2013-03-27
管孝君
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0063] There are many drugs currently used to treat cataract in clinical practice. Due to the lack of perfect basis for the formation mechanism of cataract, many drugs that are still widely used have many defects: some have low efficiency, poor pertinence, and some have relatively large side effects.
Through literature search, etc., so far, no reports have been found on the use of 2-mercapto-3-butanol as an anti-lens clouding product, especially an anti-lens clouding drug

Method used

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  • Use of 2-mercapto-3-butanol in preparation of anti-lenticular opacity products
  • Use of 2-mercapto-3-butanol in preparation of anti-lenticular opacity products
  • Use of 2-mercapto-3-butanol in preparation of anti-lenticular opacity products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0197] Example 1. Effect of 2-Mercapto-3-butanol on Oxidative Stress Opacity and Thermal Stability of Lens

[0198] 1. Materials and methods

[0199] (1) Experimental animals

[0200] 10 healthy SD rats, male, 6W age, weighing about 180g. Provided by the Experimental Animal Center of the Second Military Medical University. Clean grade and housed in an animal center.

[0201] (2) Main instruments and consumables

[0202]

[0203]

[0204] (3) Main reagents

[0205]

[0206] (4) Preparation of main reagents and solutions

[0207] ① TC-199 culture medium

[0208] Take a bag of TC-199 (9.5g / bag), add 2.2g NaHCO according to the instructions 3 , add double distilled water to make up to 1L, and adjust the pH value to 5.5. Store at 4°C. Sterilize by filtration before use.

[0209] ② 0.25mM 2-mercapto 3-butanol solution

[0210] The molecular weight of 2-mercapto-3-butanol is 351.84. Take a 100mg 2-mercapto-3-butanol powder, dissolve it in 100ml of double-distille...

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Abstract

The invention relates to a new use of 2-mercapto-3-butanol and a composition thereof in the treatment of lenticular opacity. The efficacy of the 2-mercapto-3-butanol in the aspects of preventing and treating the lenticular opacity and the like is mainly as follows: the anti-lenticular opacity action is realized by closing a channel which is positioned between nonessential mercapto of crystallin and profilin and can form a disulfide bond for causing nonspecific accumulation and further contain the formation of the macromolecular crystallin, a new medicament source and an application formulation are provided for the chemical control of cataract, and the important reference value is further realized for preventing and treating other age-related eye diseases. The 2-mercapto-3-butanol disclosed by the invention has the advantages of safety, low price, significant efficacy and stable nature, is suitable for large-scale production and commercial application in medicines, reagents and other industries and easy to popularize and apply, and further has good application prospects and significant social benefits and economic benefits.

Description

technical field [0001] The present invention relates to technical fields such as medicine, food, beverage and reagent, specifically relate to a kind of new application of protein sulfhydryl protection reagent, more specifically relate to a kind of protein sulfhydryl protection reagent 2-mercapto-3-butanol ( 2-Mercapto-3-Butanol, referred to as: 2-SH-3-butanol), and more specifically relates to the new use of 2-mercapto-3-butanol that can be used to prepare anti-lens turbid products. Background technique [0002] (1) Overview of 2-mercapto-3-butanol [0003] 2-Mercapto-3-butanol (or called: 3-Mercapto-2-butanol), CAS No.: 37887-04-0, CBNumber: CB2129062, product category: Essence and Fragrance / Fragrance / Botanical Natural Flavor / Essential Oil , English synonyms: FEMA 3502; Femano.3502; (R * , S * )-3-mercaptobutan-2-ol; 3-Mercapto-2-butanol; 3-Thio-2-butanol; 3-sulfanylbutan-2-ol; 2-MERCAPTO-3-BUTANOL; 3-MERCAPTOBUTAN-2-OL, etc.). [0004] Molecular formula: C 4 h 10 OS...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/095A61P27/12
Inventor 李闻捷管孝君邓安梅庹焱崔蓓张建荣张俊洁
Owner 管孝君
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