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New use of proanthocyanidin B2

A proanthocyanidin, disease technology, applied in the direction of medical preparations containing active ingredients, application, food science, etc., can solve the problems that have not been found in the application report of proanthocyanidin B2 anti-dementia products, and achieve good preventive and therapeutic effects

Inactive Publication Date: 2014-03-26
ZHEJIANG XIAOSHAN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0112] However, through literature search, etc., so far, no report on the application of proanthocyanidin B2 as an anti-dementia product has been found.

Method used

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  • New use of proanthocyanidin B2
  • New use of proanthocyanidin B2
  • New use of proanthocyanidin B2

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0242] As for Proanthocyanidin B 2 The preparation method is a mature method, which has been published in various journals and patent documents, and will not be repeated in the present invention.

[0243] In the present invention, the specific implementation manners described above and the examples described below are for better illustrating the present invention, and are not used to limit the scope of the invention.

Embodiment 1

[0245] Embodiment 1, the preparation of proanthocyanidin B2 tablet

[0246] prescription:

[0247]

[0248] Process:

[0249] Pass proanthocyanidin B2 through an 80-mesh sieve, mix with starch, lactose, and sodium carboxymethyl starch, and add starch slurry to make a soft material. Granulate through a 16-mesh sieve, dry below 60°C, granulate, add magnesium stearate, mix well, and compress into tablets. It can be made into 1000 tablets each containing 100mg proanthocyanidin B2.

Embodiment 2

[0250] Embodiment 2, the preparation of proanthocyanidin B2 capsules

[0251] prescription:

[0252]

[0253] Process:

[0254] Proanthocyanidin B2 passes through an 80-mesh sieve, mixes with the prescribed amount of starch and micropowder silica gel, and directly packs it into capsules to make capsules containing 100 mg of proanthocyanidin B2.

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Abstract

The invention relates to the technical fields of medicines, healthcare products and the like, and discloses a new use of vegetable active component related proanthocyanidin B2 in the preparation of products, especially medicines and healthcare products, used for preventing, diagnosing, detecting, protecting, treating and researches vascular dementia diseases and direct related diseases thereof. Experiments confirm that the proanthocyanidin B2 can improve the learning and memory ability of mice with vascular dementia caused by cerebral ischemia reperfusion lesion and rats with vascular dementia caused by focal cerebral ischemia-reperfusion. The above compound has the advantages of strong effect, obvious effect, abundant sources, stable properties, use safety, especially wide application range, and furthest effect performance. The proanthocyanidin B2 can generate obvious social and economic benefits in a short time with after popularization with the continuous increase of the incidence of dementia.

Description

[0001] This application is a divisional application of the original application "New Uses of Proanthocyanidin B2" (application number: 201210211020.4, application date: June 20, 2012). technical field [0002] The present invention relates to the technical fields of medicine, food, health products and beverages, in particular to a new application of active ingredients of traditional Chinese medicine, more specifically to a new application of proanthocyanidin compounds, and more specifically to proanthocyanidin B2 (Also known as: Proanthocyanidin B 2 ) for new uses. Background technique [0003] 1. Research overview of proanthocyanidin B2 [0004] 1. Anthocyanins [0005] Anthocyanins are water-soluble pigments that can change color with the acidity and alkalinity of the cell fluid. The cell fluid is acidic and reddish, and the cytosol is alkaline and blue. Anthocyanins are one of the main pigments that make up the color of petals and fruits. Generated via phenylpropanoi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P25/28A61P9/00A23L1/30A23L33/105
Inventor 蒋国军徐超斗毛峻琴路明珠李铁军张敏敏廖丽娜
Owner ZHEJIANG XIAOSHAN HOSPITAL
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