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Use of polygonin for preparing product for resisting dementia

A technology for polydipside and products, which is applied in the fields of medicine and food technology, can solve the problems of poor sales growth, restrict market development, and have not yet discovered polydipside, etc., and achieve the effect of significant social benefits.

Inactive Publication Date: 2009-04-22
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0127] The disadvantage of tacrine is that it has a great impact on liver function and transaminase index, which restricts the development of the market, and its sales growth is far behind other AD drugs
[0178] Through literature search, etc., so far, it has not been found that polydatin (polydatin, piceid) and its composition are directly used in the prevention, diagnosis, detection, protection, treatment and research of vascular dementia and senile dementia and their direct related diseases. Aspects of reports

Method used

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  • Use of polygonin for preparing product for resisting dementia
  • Use of polygonin for preparing product for resisting dementia
  • Use of polygonin for preparing product for resisting dementia

Examples

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preparation example Construction

[0372] (1) preparation method of Polygonum cuspidatum extract polydatin

[0373] In order to further illustrate the method for extracting polydatin from Polygonum cuspidatum extract, the following examples are used to illustrate.

[0374] For example, the preparation method of the said Polygonum cuspidatum extract of the present invention can be:

[0375] (1) Extraction: grind the medicinal material of Polygonum cuspidatum into coarse powder as usual, extract by percolation with 10-95% ethanol, and collect the percolation liquid of 5-30 times the volume of the medicinal material, which is the extract.

[0376] Or: thermally extract the pulverized Polygonum cuspidatum medicinal material with 20-95% ethanol as usual, and the volume volume of the solvent medium is about 4-8 times that of the crude drug for the first time; About 4 to 12 times of the crude drug; get the extract; filter and concentrate the extract, centrifuge or filter the concentrate;

[0377] (2) Separation and ...

Embodiment 1

[0389] Embodiment 1, preparation method one of polydatin

[0390] 10Kg of traditional Chinese medicine Polygonum cuspidatum purchased from Shanghai Medicinal Materials Company was extracted three times by percolation with 60% acetone, concentrated and evaporated to remove acetone, precipitated, and filtered to remove most of the fat-soluble substances. After the remaining part is concentrated to an appropriate volume, add water to precipitate part of the fat-soluble substances, concentrate to a small volume, and apply MCI gel CHP20P column chromatography for several times. Elute with methanol (or ethanol), combine the eluents, recover until there is no alcohol smell, place and crystallize to obtain polydatin. Chemical property analysis and spectral analysis (mainly UV spectrum, infrared spectrum, mass spectrum, hydrogen nuclear magnetic resonance spectrum and carbon spectrum) determine the structure. And then eluted with 80%~100% methanol to remove a large amount of substance...

Embodiment 2

[0391] Embodiment 2, preparation method two of polydatin

[0392] 10Kg of traditional Chinese medicine Polygonum cuspidatum purchased from Shanghai Medicinal Materials Company was extracted three times by percolation with 60% acetone, concentrated and evaporated to remove acetone, precipitated, and filtered to remove most of the fat-soluble substances. After the remaining part is concentrated to an appropriate volume, water is added to precipitate part of the fat-soluble substances. After concentration to a small volume, the polyamide column chromatography is applied to the polyamide column, firstly eluted with water, and then eluted with 10-60% methanol (or ethanol) , and the eluents were combined, recovered until there was no alcohol smell, placed for crystallization, and polydatin was obtained. Chemical property analysis and spectral analysis (mainly UV spectrum, infrared spectrum, mass spectrum, hydrogen nuclear magnetic resonance spectrum and carbon spectrum) determine th...

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Abstract

The invention relates to application of polydatin which is an extract of polygonum cuspidatum. In-vitro researching experiments show that the polydatin has strong protecting effect for pathological injuries caused by rats multiple infarctional cerebral ischemic injuries, can significantly improve learning memory function of dementia model rats, so the polydatin can be used for preparing a product for resisting vascular dementia and a product, particularly a medicine for resisting senile dementia. The modes for using the polydatin include independent use, or combined use with other chemical substances. Dementia is a key disease impacting health of the elderly, particularly, frequency of disease development of the vascular dementia and the senile dementia is significantly increased to seriously threaten health and life of human beings. The invention provides a novel drug source for clinically treating the vascular dementia and the senile dementia, and has important value for developing and utilizing medicinal plant resource in China.

Description

technical field [0001] The present invention relates to the field of medicine and food technology, in particular to the use of a traditional Chinese medicine extract, Polygonum cuspidatum extract for preparing anti-dementia products, more specifically to the use of Polygonum cuspidatum extract Polydatin in the preparation of anti-vascular dementia And the purposes of anti-senile dementia products, more specifically relate to Chinese medicine extract polydatin that is resveratrol-3-O-β-D-glucoside (piceid, polydatin, hereinafter referred to as: polydatin) for the preparation of Use of anti-vascular dementia and anti-senile dementia products. Background technique [0002] (1) Research overview of Polygonum cuspidatum [0003] 1 Overview [0004] Polygonum cuspidatum is the rhizome of Polygonum cuspidatum Sieb.et Zucc. in the family Polygonaceae. It is mostly born in valleys, streams or banks, and is a perennial shrub-like herb, more than 1 meter high. [0005] Polygonum cu...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P25/28
Inventor 肖凯姜远英曹永兵黄金灵陈万生丁雪鹰蔺红伟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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