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Use of extraced total timosaponin for producing myocardial ischemia treating products

A technology of myocardial ischemia and timosaponin, which is applied in the fields of food and beverages and medicine, can solve the problems of reducing the accuracy of analysis results, distracting anesthesiologists, and not being able to obtain them

Inactive Publication Date: 2005-10-19
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0070] 2. Consequences of myocardial ischemia
Disadvantages or problems of TEE include: high cost; inability to obtain changes before TEE insertion; intraoperative real-time analysis of TEE images can reduce the accuracy of analysis results; TEE detection may distract anesthesiologists from more important vital signs; Eligibility to present ultrasound results
[0092] Through literature search, etc., so far, it has not been found that the total timosaponin extract with timosaponin B-II as the main component is used in the prevention, diagnosis, detection, protection, treatment and research of myocardial ischemia and related diseases. report

Method used

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  • Use of extraced total timosaponin for producing myocardial ischemia treating products
  • Use of extraced total timosaponin for producing myocardial ischemia treating products
  • Use of extraced total timosaponin for producing myocardial ischemia treating products

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preparation example Construction

[0182] The preparation method of the total saponins extract of Anemarrhena of the present invention is:

[0183] (1) Extraction: thermally extract the pulverized Anemarrhena medicinal material with 20-95% ethanol according to the routine, and the volume of solvent used for the first time is about 4-8 times that of the crude drug; or percolate the pulverized Anemarrhena medicinal material with 20-95% ethanol For extraction, the solvent volume is about 4 to 12 times that of the crude drug; the extract is obtained; the extract is filtered and concentrated, and the concentrate is centrifuged or filtered;

[0184] (2) Separation and purification: the centrifuged supernatant or filtrate of the concentrated solution is adsorbed by non-polar or weakly polar macroporous resin (non-polar or weakly polar macroporous resin is polystyrene with styrene as bridging material) Ethylene-type porous adsorption resin, such as D101, D201, ZTC-1, AB-8, 1300-1 type macroporous resin, etc.), rinse wi...

Embodiment 1

[0195] Embodiment 1, the preparation method of Anemarrhena total saponins extract

[0196] Put 100 kg of pulverized anemarrhena medicinal materials into the extraction tank, heat-extract three times with 400 liters of 70% ethanol at 90-100 ° C, each extraction time is 90 minutes, combine the three extracts, concentrate to 80 liters, and filter , the filtrate was adjusted to 100 liters with distilled water. Then slowly pass through the adsorption column that 350 liters of ZTC-1 type macroporous resin (produced by Tianjin Zhengtiancheng Clarification Technology Co., Ltd.) is housed, remove impurities by eluting with 500 liters of distilled water and 1000 liters of 20% ethanol, and then use 1000 liters of 45% ethanol to remove impurities. Eluted with ethanol, collected the eluate, concentrated to dryness, dried and pulverized to obtain a yellow powder, which was the total timosaponin extract of the present invention, with a total weight of 2.7 kg and a yield of 2.7% based on the ...

Embodiment 2

[0197] Another preparation method of embodiment 2, Anemarrhena total saponins extract

[0198] Cut Anemarrhena into thin slices, take 100kg, infiltrate with 300L of 30% ethanol for 12 hours, extract by percolation, and collect 2400L percolation liquid. Concentrate the percolation liquid to 150L; filter the concentrated liquid, pass the filtrate into a chromatographic column filled with 200L D101 resin, and successively elute with 3000L of distilled water, 3000L of 20% ethanol, and 1200L of 60% ethanol, and collect 60% ethanol for elution Parts were concentrated to dryness, dried and pulverized to obtain a yellow powder, which was the total timosaponin extract of the present invention, with a total weight of 3.1 kg and a yield of 3.1% based on the crude drug amount.

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Abstract

The present invention relates to the new use of total timosaponin as one Chinese medicine extract. The extract has timosaponin B-II compound as main component in the content of 30-70 % and is obtained through conventional extraction, separation and purification process. The extract has powerful pharmaceutical effect of diagnosing and treating myocardial ischemia and relevant diseases. It has simple preparation process, high yield, stable chemical property and safety and use wide application range.

Description

technical field [0001] The invention relates to the technical fields of medicine, food and beverage, in particular to the use of Chinese medicine extracts, and more specifically to the use of total timosaponin extracts for preparing myocardial ischemia products. Background technique [0002] (1) An overview of the research on Zhimu [0003] Anemarrhena (Rhizoma Anemarrhenae) is the rhizome of Anemarrhena asphodeloides Bunge, a plant of the Liliaceae family. It is also known as Garlic clove grass and Lianmu. It is born in mountains, dry hills or grasslands, mainly in Hebei. It is excavated every spring and autumn, removes fibrous roots and soil, and dries in the sun, which is commonly called "Mao Zhimu"; removes the outer skin, and is called "Anemarrhena meat" when dried in the sun. [0004] Anemarrhena is a perennial herb. Ye Jisheng, linear, slightly hard, 20-70cm long, 0.3-0.6cm wide. Flower stems 40-60cm high, scattered with scale-like bracteoles; 2-6 flowers scattered...

Claims

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Application Information

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IPC IPC(8): A61P9/10
Inventor 娄子洋陈万生
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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