Application of rotundic acid in preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases

A technology for cardiovascular and cerebrovascular diseases and Bing acid, which is applied in the field of medicine, can solve the problems of inconsistent biological activity and reduce dosage, and achieve the effects of short production cycle, low cost and broad application prospects.

Inactive Publication Date: 2010-10-13
吉林益民堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The significance of the present invention is that the total saponins are degraded by alkali in vitro before taking the extract of jiubing to obtain the active ingredient jiubing acid that can be absorbed into the blood, which solves the problem of rough extraction of jiubing due to individual differences. The problem of inconsistency in biological activity due to the different degrees of degradation of drugs in the body, and at the same time reduce the dosage and reduce the toxic and side effects of drugs

Method used

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  • Application of rotundic acid in preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases
  • Application of rotundic acid in preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases
  • Application of rotundic acid in preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1 , the preparation method of bisphosphonic acid

[0058] Add 2% of the weight of the medicinal material to the medicinal material of calcium oxide, reflux extraction with 70% ethanol for 3 times, each time for 2 hours, combine the extracts, add 1% medicinal active carbon to the volume of the medicinal solution, filter, and concentrate the filtrate to 1ml Containing 1g of medicinal materials, add 3 times the amount of water, stir, adjust the pH value to 6 with dilute hydrochloric acid, place it, filter, wash the precipitate with water until neutral; heat the precipitate with 30 times the amount of 80% ethanol, add the volume of the medicinal solution 0.5% of medicinal activated carbon, filtered while hot, the filtrate recovered solvent to contain 1g of medicinal materials per 1ml, add 2 times the amount of water, stir, place, filter, filter cake drying, save Bing total saponins; total saponins contain 25% 50 times the amount of 1 mol / l sodium hydroxide solution...

Embodiment 2

[0059] Example 2 , the preparation method of bisphosphonic acid

[0060]Add 3% of the weight of the medicinal material to the medicinal material of calcium oxide, reflux extraction with 80% ethanol for 3 times, each time for 2 hours, combine the extracts, add 2% medicinal active carbon to the volume of the medicinal solution, filter, and concentrate the filtrate to 1ml Containing 1g of medicinal materials, add 4 times the amount of water, stir, adjust the pH value to 6 with dilute hydrochloric acid, let it stand, filter, wash the precipitate with water until neutral; dissolve the precipitate with 30 times the amount of 85% ethanol, add the volume of the liquid 0.2% medicinal activated carbon, filtered while hot, the filtrate recovered the solvent to contain 1g of medicinal materials per 1ml, added 2 times the amount of water, stirred, placed, filtered, and the filter cake was dried. The total saponins of the rescued Bing; the total saponins contained 10% 60 times the amount ...

Embodiment 3

[0061] Example 3 , the preparation method of bisphosphonic acid

[0062] Add 0.5% of the weight of the medicinal material to the medicinal material of calcium oxide, reflux extraction with 50% ethanol for 3 times, each time for 2 hours, combine the extracts, add 0.3% medicinal activated carbon to the volume of the medicinal solution, filter, and concentrate the filtrate to 1ml Containing 1g of medicinal materials, add 5 times the amount of water, stir, adjust the pH value to 6-7 with dilute hydrochloric acid, place it, filter, wash the precipitate with water until neutral; heat the precipitate with 60 times the amount of 95% ethanol, add the drug 0.5% of the liquid volume of medicinal activated carbon, filtered while hot, the filtrate recovered the solvent to contain 1g of medicinal materials per 1ml, added 3 times the amount of water, stirred, placed, filtered, and the filter cake was dried to save Bing total saponins; total saponins added 50 times the amount of 2mol / l sodi...

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Abstract

The invention relates to the technical field of medicines and provides a new method for extracting rotundic acid from dry barks of llex rotundaThunb and preparing the rotundic acid. Pharmacodynamic tests prove that the rotundic acid has the function of preventing and treating cardiovascular and cerebrovascular diseases and can be applied to preparing the medicines for treating cardiovascular and cerebrovascular diseases. Specifically, the rotundic acid has the functions of improving myocardial ischemia and myocardial infarction, improving resistance to anoxia, obviously lowering whole blood specific viscosity and plasma specific viscosity and bettering cerebral ischemia and cerebral infarction. Made into oral preparation or injection, the rotundic acid is used for preventing and treating ischemic cardiovascular and cerebrovascular diseases, stenocardia, myocardial infarction and cerebral infarction.

Description

technical field [0001] The present invention relates to a new medical application of basic acid, which is used for preparing medicines for preventing and treating cardiovascular and cerebrovascular diseases. Concretely speaking, bisacid can improve myocardial ischemia and myocardial infarction, improve hypoxia tolerance, significantly reduce whole blood specific viscosity and plasma specific viscosity, and improve cerebral ischemia and cerebral infarction. It also relates to the pharmaceutical preparation of the medicine, and the invention belongs to the technical field of medicine. Background technique [0002] Cardiovascular and cerebrovascular diseases are collectively referred to as cardiovascular diseases and cerebrovascular diseases. Generic name for disease. Cardiovascular and cerebrovascular diseases have become a major public health problem in the world, especially in my country. The total morbidity and mortality of cardiovascular and cerebrovascular diseases in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P9/10C07J63/00
Inventor 赵全成南敏伦赫玉芳陈声武
Owner 吉林益民堂制药有限公司
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