35results about How to "Prevent negative consequence" patented technology

A method of screening peptides which bind to at least one PDZ domain and comprise a cell-membrane transduction domain for use in treating traumatic injury to the brain or spinal cord by deforming neurons on a flexible substrate with sublethal stretch, then inflicting a secondary injury, and determining survival of the stretched neurons in the absence or presence of the peptide which is being screened.

A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron the method comprising administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor neuronal protein. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity and ischemic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95 / NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults and dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia. The treatment was effective when applied either before, or one hour after, the onset of excitotoxicity in vitro and cerebral ischemia in vivo. This approach prevents negative consequences associated with blocking NMDAR activity and constitutes practical therapy for stroke.

A method for setting a combustion in a combustion engine, particularly in a diesel engine, having the following steps of generating a manipulated variable, particularly a point of injection (PI), as a function of a combustion feature (MFB50%), the combustion feature (MFB50%) representing a condition in cylinder, especially a pressure characteristic in the cylinder, and setting the combustion in cylinders of the combustion engine with the aid of the manipulated variable, the manipulated variable further being generated as a function of a correction value (CV), which is determined as a function of combustion information (dQmax) that provides an indication about the quality of the combustion.

A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor-neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARS) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95 / NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults, dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia, and traumatic brain injury (TBI) in rats.

A method is described for controlling a compression-ignition internal combustion engine, including predefining a setpoint combustion point for a compression-ignition internal combustion engine, predefining a calculation model for calculating a probable deviation of a future cycle of the engine from the predefined setpoint combustion point while taking an ascertained actual combustion point of a completed cycle engine into consideration, predefining a mean deviation for the engine, operating the engine for a first cycle and ascertaining an actual combustion point of the first cycle, calculating a probable deviation of a second cycle, which occurs after the first cycle, of the engine from the predefined setpoint combustion point, comparing the calculated probable deviation of the second cycle to the predefined mean deviation, and ascertaining at least one operating variable for operating the engine at least during the second cycle as a function of the comparison. Also described is a related method.

A tablet press comprises a gate that defines a first switching position that feeds tablets into a first tablet outlet and at least a second switching position that feeds tablets into at least one second tablet outlet. The table press further comprises a control apparatus and a drive apparatus. The drive apparatus is configured to be actuated by the control apparatus to move the gate from a home position defined as one of the first switching position and the at least a second switching position into a target position defined as a switching position that is not the home position. The gate is moved from the home switching position at a speed of movement toward the target position such that the speed of movement of the gate is reduced before the target position is reached.

A method of detecting a network hang and restoring an application that communicates on a connection giving rise to the network hang. A user experience may be improved by providing the user with an option to restore the hung application without losing unsaved data or state information. The network hang may be detected when the user tries to terminate the application. The method may include determining whether the network hang is recoverable, which may involve diagnosing a type of the hang. If recoverable, a network connection reset mechanism may be triggered by instructing a network stack of the computer to terminate the network connection.