55 results about "Viral spread" patented technology

The invention relates to the technical field of infectious disease on-site simulation, in particular to a respiratory infectious disease on-site epidemic AI simulation experiment system based on environment evaluation. Performing virus region diffusion analysis based on a virus propagation risk assessment result, the environment data and the contact condition of nearby facilities, performing path virus risk assessment based on a path virus region diffusion analysis result, a personnel evacuation condition and a virus attenuation condition, and acquiring an evacuation path according to a path virus risk assessment result. By evaluating the risk of the virus in the path, the path with relatively low virus transmission risk can be accurately identified, and the path is selected for personnel evacuation in the period of infectious disease outbreak, so that the contact opportunity between evacuated personnel and the virus can be reduced to the greatest extent, the possibility of infectious disease infection is effectively reduced, and the life health and safety of the public are guaranteed.

The present invention uses ex vivo human airway cultures to assess the human transmissibility and replication competence of influenza and coronavirus strains. By comparing pandemic influenza A subtype H1N1 and highly pathogenic avian influenza H5N1 as reference strains, the transmissibility risk of various viruses was evaluated and categorized. Additionally, an in vitro model evaluated virus-induced impairment of alveolar fluid clearance (AFC) as an indicator of disease severity. The study revealed correlations between bronchus viral replication, human transmission, AFC impairment, and clinical disease severity across different influenza and coronavirus strains.

The invention discloses a monitoring and prevention method for comprehensive prevention and control of tobacco viruses. The monitoring and prevention method comprises the following steps: S1, collecting tobacco virus monitoring data; s2, analyzing a virus infection risk index through the monitoring data; s3, preparing a comprehensive virus control agent; s4, collecting leaf states of the tobacco plants; s5, judging an infection propagation direction by combining multi-dimensional data; according to the method, concentration data of root system metabolites and leaf VOCs are collected at the same time, and multi-parameter conjoint analysis of virus invasion is achieved; through joint analysis of VOCs concentration data in the orientation, root system metabolites and leaf apparent parameters, the numerical value change trend in the virus propagation direction is quantified, and accurate positioning of a propagation path is achieved; through multi-dimensional data fusion, dynamic model quantitative analysis and physical blocking and medicament cooperative prevention and control, early warning, accurate judgment, propagation direction quantification and efficient prevention and control of tobacco virus infringement are realized, and a complete closed loop from monitoring to intervention is formed.

Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and / or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.

The invention discloses a generative agent-based Ebola virus social simulation system and a generative agent-based Ebola virus social simulation method, which are used for dynamically simulating the interactive influence of social behaviors and virus propagation by integrating an SEIR infectious disease model and a generative agent framework. The system comprises a social factor interaction module, an experimental scene configuration module and a dynamic analysis module, supports high-fidelity simulation of scenes such as management scheme deviation and resource allocation optimization, and can quantitatively evaluate social chain reactions (for example, the infection rate is reduced by 30%-40%) of prevention and control measures. According to the method, the defect that a traditional model ignores social complexity is overcome, a prospective experimental platform is provided for policy making of social sensitive infectious diseases such as Ebola, and the method is adapted and expanded to other infectious disease research.

The utility model discloses a ceiling type air purification sterilizing device for preventing and treating infectious diseases. The ceiling type air purification sterilizing device comprises a cylindrical sterilizing box, an air guide device is arranged in the sterilizing box, a trumpet-shaped air inlet is formed in the lower end of the sterilizing box, and an exhaust port is formed in the side face of the upper end of the sterilizing box; compared with the prior art, the disinfection box has the beneficial effects that after air below the indoor disinfection box is sucked into the air inlet, the air is transversely discharged outwards from the air outlet after disinfection treatment, and the discharged air contains a disinfectant component with a certain concentration, so that viruses in public places can be effectively disinfected; meanwhile, due to the fact that the disinfecting and killing box is installed on the ceiling, air in the space below the disinfecting and killing box can be fully absorbed and treated, the exhausted air flow containing disinfectant components flows in the space from top to bottom, full-coverage and dead-corner-free disinfecting and killing are achieved, the air disinfecting and killing treatment effect is effectively improved, and a virus transmission chain is blocked.

The utility model relates to an anti-displacement quilt structure containing pills, which belongs to the technical field of quilts, and comprises a quilt cover and a partition layer sewn in the quilt cover and dividing the quilt cover into two accommodating cavities, quilt layers are filled in the two accommodating cavities, a pill laying layer is arranged between the quilt layer and the partition layer, and the pill laying layer is arranged between the quilt layer and the partition layer. The pill laying layer comprises a protective layer, a plurality of open holes formed in the protective layer and pockets sewn in the open holes, and the pockets are made of breathable mesh gauze. In the using process, the bedding is filled with the pills, so that in the laying process of a patient, peculiar smell can be removed, and the patient can feel comfortable. The anti-bacterial effect is achieved, the bedding can effectively cut off propagation of bacteria and viruses in daily use, and the anti-mosquito and anti-fly effects are achieved, so that propagation of the viruses is further reduced, and rapid recovery of a patient is facilitated.

The invention relates to the technical field of spreading modes of human viruses, in particular to a virus spreading mode prediction model based on interaction of virus protein and human protein, a prediction model construction method and a prediction method. The method specifically comprises the following steps: S1, constructing a training data set of a virus transmission mode; s2, based on the data in the S1, obtaining a virus-human protein interaction prediction result, vectorizing the prediction result by using 0 / 1 coding, and constructing a virus-human protein interaction matrix; and S3, using a machine learning algorithm and a feature selection project to construct and train a virus propagation mode prediction model based on the interaction of the virus protein and the human protein. The method for predicting the virus propagation mode of interaction between the virus protein and the human protein is convenient to use and wide in application range; the method is especially suitable for new viruses or unknown viruses which are not fully researched, and can realize efficient and rapid propagation mode identification.

The present invention discloses an automatic air supply filter transport protection device for infected newborns, comprising a bed board, a mounting plate fixedly mounted on the lower side of the bed board, an incubator connected to the bed board, a disinfection device mounted in the mounting plate, and the interior of the incubator being connected to the outside world via the disinfection device. The incubator provided by the present invention effectively isolates the newborns from direct human contact during transport, effectively prevents the occurrence of human-to-human transmission, cuts off the transmission path of the virus and effectively curbs the spread of the virus. The air in the incubator is extracted by an air pump, forming a negative pressure in the incubator to prevent the air in the incubator from being directly discharged. When the air in the incubator is discharged, it is first disinfected by the disinfection device to prevent the virus from being directly discharged into the air and causing the spread of the virus.

The invention relates to the substances benfo-oxythiamine and / or oxythiamine for use as the active ingredient of a topically administered medicament for the therapeutic treatment of patients with a disease of the body surface skin (cutis and subcutis) and / or one or more mucous membranes (mucosa) caused by viruses. The medicament is administered at a time when viral replication has already taken place and viral release from the host cell(s) is imminent.Benfo-oxythiamine and / or oxythiamine cause (I) a slowing or prevention of the spread mechanisms of the viruses, so that the viruses remain in their host cells after replication and cell damage in the patient organism (host organism) is reduced or prevented, and (II) an immune response against the viruses remaining in the cells, so that the patient's immune system is activated or reactivated to generate an effective immune response against the viruses.

The application discloses a dry type closed burying sterilization spittoon, which comprises a barrel, a conical flocking pre-paved accumulation sand tray, a sand conveying pipe and a powder tube inner pushing and conveying mechanism; the barrel is used for collecting and containing sterilization sand; a sand tray mounting through hole is formed in the center position of the conical flocking pre-paved accumulation sand tray; a sand inlet is formed in the lower end wall of the sand conveying pipe, and a powder tube inner conveying return valve device is arranged in the sand conveying pipe; the powder tube inner pushing and conveying mechanism is used for pushing the sterilization sand in the sand conveying pipe to move upwards along the sand conveying pipe and overflow from the upper end of the sand conveying pipe to the upper surface of the conical flocking pre-paved accumulation sand tray. The application further discloses a garbage classification function integrated machine. The application adopts a dry type burying mode to collect sputum, cigarette butts and the like, can effectively prevent bacteria and viruses in the sputum from spreading into the air, reduces the spread of infectious diseases and smog pollution of the environment.

The utility model provides a disposable sterile protective cover. The disposable sterile protective cover comprises a main body assembly and a fixing assembly, the main body assembly comprises a cover body, a flexible bottom edge is arranged at the bottom of the cover body, a supporting frame is arranged on the inner wall of the cover body, a pair of operation openings are formed in one end of the cover body, rubber gloves extending towards the interior of the cover body are arranged at the operation openings, an air inlet and an air outlet are further formed in the cover body, and one-way valves are arranged at the air inlet and the air outlet. A window is further formed in the cover body, a protective sticker is adhered to the window, and a connecting assembly aiming at an infusion tube is arranged on the cover body close to the window in a penetrating manner; the fixing assembly comprises a hard frame, the top of the hard frame is provided with a first bonding layer used for being bonded with the flexible bottom edge, and the bottom of the hard frame is provided with a second bonding layer used for being bonded with a sickbed. The disposable sterile protective cover provided by the utility model can effectively isolate an infectious patient and effectively prevent virus transmission, is also convenient for medical personnel to nurse the patient, and is ingenious in structural design and easy to operate and use.

In the present invention, cyclic dinucleotides or their compositions are used as biological response modifiers to enhance the immune response of subjects with deficient immune systems, with a low or absent response to vaccine antigens, or with a deficient immune response to pathogens. The formulations of the present invention are capable of modifying the biological response in such a way as to eliminate the lack of response, resulting in the development of a high-avid immune response that prevents disease caused by infectious agents, particularly viruses with the ability to evade immune surveillance mechanisms and, consequently, suppress the induction of an effective, high-avid adaptive response.The present invention also comprises cyclic dinucleotide formulations, which can be administered alone, in combination with other biological response modifiers, or in vaccine formulations with antigens. The proposed invention further includes a method for preventing or treating acute respiratory infections, preventing disease severity, and blocking transmission by inducing an immune response at the point of entry (nasopharyngeal mucosa), preventing or reducing person-to-person transmission of pathogens / viruses in preventive vaccine formulations, as well as in formulations used for prophylaxis before and after exposure to acute respiratory infections.

The invention relates to the technical field of biological medicines, and aims to provide application of glutamic acid in preparation of a medicine for treating pseudorabies virus infection. Particularly, glutamic acid is applied to preparation of drugs for treating pseudorabies virus infection. The medicine takes glutamic acid as an active component, and comprises an effective amount of glutamic acid and pharmaceutically acceptable auxiliary materials. It is proved for the first time that glutamic acid can remarkably inhibit PRV replication in PK-15 cells, the effectiveness of glutamic acid in the aspects of inhibiting virus replication and improving infection symptoms and the remarkable effect of glutamic acid in the aspects of improving the survival rate and weight change of infected mice are verified, and a new scientific basis and practical support are provided for prevention and control of PRV infection. The traditional Chinese medicine composition has the characteristics of high safety and small toxic and side effects, and is low in price, easy to obtain and suitable for being popularized and used in farms. A novel treatment method is provided for coping with prevalence of porcine pseudorabies, virus transmission in pig farms is expected to be prevented, and economic losses are reduced.

The invention provides a programmable robot control system, which relates to the technical field of robot control, and comprises a flexible humidity sensor array, an energy storage module, a resistance acquisition device, Bluetooth and a robot control end, the energy storage module supplies power to the resistance acquisition device and the Bluetooth, the flexible humidity sensor array is connected with the resistance acquisition device, the resistance acquisition device uploads acquired data to the robot control system through the Bluetooth, and the robot control system processes the data and converts the data into corresponding control signals so as to control movement of the programmable robot. According to the technical scheme, the problem that in the prior art, a programming robot is controlled in a contact mode, and bacteria or viruses are likely to be spread is solved.

The present application relates to compositions and methods for: (a) preventing or treating viral infections; and / or (b) preventing the transmission and / or spread of infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety that specifically binds to a virus, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating viral infections, preventing the transmission of a viral infection from an infected individual to a non-infected individual, and for preventing the spread of a viral infection within a population of individuals.

The present invention provides a virus-like particle and a preparation method and application thereof, belonging to the field of agricultural science, animal husbandry and veterinary science and technology. The present invention uses a small ubiquitin-like modified protein as a tag protein to promote the correct folding of viral structural proteins VP0, VP1 and VP3, while ensuring the structural stability of the protein, achieving a large amount of expression of the structural protein, and obtaining a large number of virus-like particles with similar performance to natural viruses after the three structural proteins self-assemble in vitro. After immunogenicity testing, the virus-like particles prepared by the present invention have high immunogenicity and can be used as a reserve vaccine in the prevention and control of the spread of swine vesicular disease or foot-and-mouth disease virus.

The invention relates to the technical field of plant propagation, in particular to a Lanzhou lily scale cuttage method. According to the method, virus transmission can be effectively reduced through combination of double disinfection and trichoderma biological control, the risk of soil-borne diseases is reduced, the qualified rate of commercial bulbs is increased, meanwhile, the cultivation period of the commercial bulbs can be greatly shortened through hormone optimization treatment of single scales and a film mulching drip irrigation technology, and the economic benefit is increased. Through double-film covering and precise water and fertilizer management, the irrigation cost can be effectively reduced, the fertilizer utilization rate can be increased, the yield per mu and the commodity ball optimization rate can be remarkably increased, comprehensive breakthrough is achieved in efficiency, cost and quality, and the method is suitable for large-scale planting and industrial upgrading requirements.

This item is a cover for a box-shaped livestock storage rack that has multiple storage spaces capable of accommodating livestock such as chickens. It is used to prevent the spread of viruses during disease control operations in the event of an outbreak of livestock infectious diseases such as avian influenza. The right and left sides of the cover are each provided with a zipper, one near the left edge and one near the right edge, extending from the bottom edge to near the top edge. As shown in the reference perspective diagram of the usage state, when both zippers are opened, the portion sandwiched between these zippers can be rolled up to expose the livestock storage rack, allowing for work on the rack, such as storing livestock. Each edge of the top surface of the cover is provided with a flap that protrudes outward, and this flap can be grasped to attach or detach the cover.

A method (400) for reducing the propagation of viruses in an enclosed space (102) includes providing (404) a minimum humidity ratio threshold that reduces the propagation of a particular virus. The method (400) further includes determining (406) a humidity ratio of the enclosed space (102) adapted to receive the organism. The method (400) further includes, in response to determining (410) that the humidity ratio is less than the minimum humidity ratio threshold, increasing (412) the humidity ratio until the humidity ratio in the enclosed space (102) is at least equal to the minimum humidity ratio threshold.

The present invention originates from a system for preventing or minimizing the spread of viruses and preventing or minimizing the spread of viruses in indoor air, which has one or more light sources (10) indoors that divide a room into multiple small compartments by means of a so-called UV-C emitting wall, a sensor device for detecting the movement or presence of one or more persons (P) in the room, and a controller (16) designed to at least partially turn on and off one or more light sources (10) at least based on the presence of a person (P). It is proposed that the one or more light sources (10) are designed to respectively generate a wall-shaped light zone (10b), which serves as a UV-C wall, thereby dividing the room into multiple small compartments, which prevents or minimizes the spread of viruses because the viruses are inactivated by the UV-C light, and the controller (16) is designed to at least partially turn off the relevant light source (10) when the movement data detected from the sensor device indicates that it is possible that one of the persons (P) wants to cross the relevant light zone (10b).

The application discloses an intelligent lock, comprising an outdoor lock body and an indoor lock body; wherein the outdoor lock body comprises an outdoor handle, an outdoor panel and an outdoor mounting fixed plate in sequence along the transverse direction; the outdoor panel is provided with an outdoor unlocking unit, which is provided with a reflective material layer; the outdoor handle is connected with the outdoor panel, and the side, opposite to the outdoor unlocking unit, of the outdoor handle is provided with an ultraviolet disinfection device; the ultraviolet disinfection device can generate ultraviolet rays covering the reflective material layer of the outdoor unlocking unit, and the reflective material layer can reflect the ultraviolet rays to the outdoor handle; the area of the outdoor handle, except the ultraviolet disinfection device, and the area of the outdoor panel, except the outdoor unlocking unit, are coated with electrophoretic paint containing an antibacterial agent; the outdoor mounting fixed plate is connected with the outdoor panel to fix the outdoor lock body on the outdoor side of the door. The intelligent lock can automatically and comprehensively disinfect the outdoor unlocking unit and the outdoor handle through the ultraviolet disinfection device, cut off the spread of bacteria and viruses, and facilitate the safe use of the user.

Embodiments of the present application provide a virus infection prediction method and device, electronic equipment and storage medium. The method comprises obtaining sewage samples of a plurality of preset monitoring sites, performing gene sequencing on the sewage samples of each monitoring site to obtain gene sequence data of each monitoring site, and performing virus concentration identification on the sewage samples of each monitoring site to obtain the virus concentration of each monitoring site; performing gene analysis on the gene sequence data of each monitoring site, and constructing a phylogenetic tree corresponding to the plurality of monitoring sites based on the gene analysis result; determining a virus transmission path based on the phylogenetic tree, and updating parameters of a virus infection model based on the virus transmission path; and performing infection prediction on the virus concentration of each monitoring site based on the parameter-updated virus infection model to obtain a virus infection trend. The method can provide virus infection prediction accuracy.

The invention relates to the technical field of plant pruning equipment, and discloses plant virus propagation blocking pruning equipment which comprises a set of handle rings, a collecting groove is formed in one end of each handle ring, a center shaft penetrates through the collecting grooves, scissor blades are arranged in the collecting grooves in a sliding mode and used for making contact with plant pruning, and a telescopic assembly is arranged on the center shaft; adjusting assemblies are arranged on the surfaces of one ends of the scissor blades; the telescopic assembly is used for telescopically adjusting the length of the scissor blade; the adjusting assembly is used for adjusting the angle according to different use scenes; rubber and plastic heat preservation materials are arranged on the surfaces of the handle rings; a trigger switch is arranged on one side of the handle ring, a heating wire is arranged on the scissor blade, and a storage power source is arranged in the handle ring. Compared with the prior art, residual impurities on the surfaces of the blades of the scissors are effectively reduced, the risk of pathogen diffusion is reduced, multi-angle pruning is achieved, and the equipment is made to meet the pruning requirements of different plants.

The invention discloses an application of flubendazole in preparation of a medicine for resisting flavivirus virus infection. According to the invention, the established Zika virus intercellular transmission model is processed by using the flubendazole, and the result shows that the flubendazole can inhibit the intercellular transmission of the Zika virus. On the basis, the combination of the flubendazole and the neutralizing antibody MZ54 of the targeted Zika virus E protein discovers that the inhibition effect on Zika virus transmission can be remarkably improved through the combination of the flubendazole and the neutralizing antibody MZ54. Therefore, the flubendazole can be used for preparing a medicine for resisting flavivirus infection, and the flubendazole can be combined with a neutralizing antibody of a targeted flavivirus to realize the effect of resisting virus infection. The invention is beneficial for inhibiting the transmission of Zika virus, is beneficial for preventing and treating viral diseases caused by flavivirus virus infection, and has important significance for maintaining public health and safety.

The utility model relates to the technical field of receiving devices, in particular to a vomit receiving device which comprises a box body assembly, the box body assembly comprises a base, the upper surface of the base is fixedly connected with a cabinet body, the upper surface of the cabinet body is fixedly connected with a handrail, the upper surface of the cabinet body is fixedly connected with a flushing assembly, and the flushing assembly comprises a wash basin. The wash basin is fixedly connected with the upper surface of the cabinet body, the lower surface of the wash basin is fixedly connected with a sewer pipe, the upper surface of the cabinet body is fixedly connected with a faucet, the other end of the sewer pipe is fixedly connected with a water pump, the dirt receiving assembly comprises a placing frame, and one side of the placing frame is fixedly connected with a support. According to the vomitus cleaning device, the risk of pathogen and virus transmission is reduced, the health of patients and medical staff is protected, the wash basin and the faucet enable the patients to conveniently clean the oral cavity and the face after vomiting, more comfort is provided, discomfort and psychological stress after vomiting are reduced, and vomitus can be directly collected and treated due to the existence of the wash basin.

The present invention discloses a highly secure novel coronavirus antigen detection kit comprising a test card, a swab, and a sample buffer. The sample buffer comprises the following components, measured by mass: 0.5-4 parts realgar, 0.5-4 parts borneol, 3-8 parts peppermint oil, 3-8 parts alum, 5-10 parts rosin, 5-10 parts tannic acid, 1-20 parts sucrose, 3-20 parts sodium chloride, 0.5-1.5 parts casein, 1-10 parts anionic surfactant, 0.5-3 parts sodium benzoate, 0.5-3 parts preservative, 0.01-0.03 parts chelating agent, 10-40 parts rice wine, and 700-1500 parts sterile water. This kit enhances safety while reducing the risk of virus transmission, protects low-level structural proteins, improves detection accuracy, and accelerates the chromatography speed of the sample buffer in the test card, shortening detection time.

In the present invention, a cyclic dinucleotide or a composition thereof is used as a biological response modulator to improve an immune response in a subject having a low immune system function, a low / no response to a vaccine antigen, or a poor immune response to a pathogen. The formulations of the present invention are able to alter biological responses in a manner that eliminates non-responsiveness, thereby producing a high affinity immune response to prevent diseases caused by infectious agents, in particular viruses, which have the ability to evade the immune surveillance mechanism and thus inhibit the induction of high affinity and efficient adaptive responses. The invention also includes formulations of cyclic dinucleotides that can be administered alone, in combination with other biological response modulators, or in antigen-containing vaccine formulations. The proposed invention also includes methods of preventing or treating acute respiratory infections, preventing disease severity and blocking propagation by inducing an immune response at the entry site (nasopharyngeal mucosa), whether in a prophylactic vaccine formulation or in a formulation for prophylaxis before / after exposure of acute respiratory infections, and pathogen / virus transmission between people can be prevented or reduced.

The present invention provides a programmable robot control system, which relates to the technical field of robot control and includes: a flexible humidity sensor array, an energy storage module, a resistance acquisition device, Bluetooth, and a robot control terminal; the energy storage module powers the resistance acquisition device and Bluetooth, the flexible humidity sensor array is connected to the resistance acquisition device, the resistance acquisition device uploads the collected data to the robot control system through Bluetooth, and the robot control system processes the data and converts the data into corresponding control signals to control the movement of the programmable robot. The technical solution of the present invention overcomes the problem in the prior art that controlling a programming robot by a contact method is likely to cause the spread of bacteria or viruses.

The harmless collecting and transferring device comprises a transferring compartment body, the transferring compartment body is a heat preservation compartment body internally provided with refrigeration equipment, a feeding port is formed in the top of the transferring compartment body, a feeding door is installed on the feeding port, and a feeding door opening and closing driving mechanism is connected between the feeding door and the transferring compartment body; a hook arm towing hook and a carriage body lifting oil cylinder are arranged on the front side of the transfer carriage body, the carriage body lifting oil cylinder is used for driving the front portion of the transfer carriage body to move upwards, a rear door is arranged on the rear portion of the transfer carriage body, the upper end of the rear door is rotationally connected with the transfer carriage body through a first rotating shaft, and a rear door locking mechanism is arranged between the lower end of the rear door and the transfer carriage body. And rear rollers are arranged on the bottom surface, close to the rear end, of the transfer carriage body. The livestock and poultry transport compartment can be independently placed at a livestock and poultry breeding point, the transport compartment body is provided with the refrigeration equipment, the interior of the transport compartment body is in a closed low-temperature state, livestock and poultry stored in the transport compartment body are not prone to rot, the transport compartment body can be hauled to a designated place to be unloaded after being fully loaded, and virus spreading can be effectively reduced.