23 results about "Viral spread" patented technology

The invention discloses a monitoring and prevention method for comprehensive prevention and control of tobacco viruses. The monitoring and prevention method comprises the following steps: S1, collecting tobacco virus monitoring data; s2, analyzing a virus infection risk index through the monitoring data; s3, preparing a comprehensive virus control agent; s4, collecting leaf states of the tobacco plants; s5, judging an infection propagation direction by combining multi-dimensional data; according to the method, concentration data of root system metabolites and leaf VOCs are collected at the same time, and multi-parameter conjoint analysis of virus invasion is achieved; through joint analysis of VOCs concentration data in the orientation, root system metabolites and leaf apparent parameters, the numerical value change trend in the virus propagation direction is quantified, and accurate positioning of a propagation path is achieved; through multi-dimensional data fusion, dynamic model quantitative analysis and physical blocking and medicament cooperative prevention and control, early warning, accurate judgment, propagation direction quantification and efficient prevention and control of tobacco virus infringement are realized, and a complete closed loop from monitoring to intervention is formed.

The invention discloses a generative agent-based Ebola virus social simulation system and a generative agent-based Ebola virus social simulation method, which are used for dynamically simulating the interactive influence of social behaviors and virus propagation by integrating an SEIR infectious disease model and a generative agent framework. The system comprises a social factor interaction module, an experimental scene configuration module and a dynamic analysis module, supports high-fidelity simulation of scenes such as management scheme deviation and resource allocation optimization, and can quantitatively evaluate social chain reactions (for example, the infection rate is reduced by 30%-40%) of prevention and control measures. According to the method, the defect that a traditional model ignores social complexity is overcome, a prospective experimental platform is provided for policy making of social sensitive infectious diseases such as Ebola, and the method is adapted and expanded to other infectious disease research.

The utility model discloses a ceiling type air purification sterilizing device for preventing and treating infectious diseases. The ceiling type air purification sterilizing device comprises a cylindrical sterilizing box, an air guide device is arranged in the sterilizing box, a trumpet-shaped air inlet is formed in the lower end of the sterilizing box, and an exhaust port is formed in the side face of the upper end of the sterilizing box; compared with the prior art, the disinfection box has the beneficial effects that after air below the indoor disinfection box is sucked into the air inlet, the air is transversely discharged outwards from the air outlet after disinfection treatment, and the discharged air contains a disinfectant component with a certain concentration, so that viruses in public places can be effectively disinfected; meanwhile, due to the fact that the disinfecting and killing box is installed on the ceiling, air in the space below the disinfecting and killing box can be fully absorbed and treated, the exhausted air flow containing disinfectant components flows in the space from top to bottom, full-coverage and dead-corner-free disinfecting and killing are achieved, the air disinfecting and killing treatment effect is effectively improved, and a virus transmission chain is blocked.

The invention relates to the technical field of spreading modes of human viruses, in particular to a virus spreading mode prediction model based on interaction of virus protein and human protein, a prediction model construction method and a prediction method. The method specifically comprises the following steps: S1, constructing a training data set of a virus transmission mode; s2, based on the data in the S1, obtaining a virus-human protein interaction prediction result, vectorizing the prediction result by using 0 / 1 coding, and constructing a virus-human protein interaction matrix; and S3, using a machine learning algorithm and a feature selection project to construct and train a virus propagation mode prediction model based on the interaction of the virus protein and the human protein. The method for predicting the virus propagation mode of interaction between the virus protein and the human protein is convenient to use and wide in application range; the method is especially suitable for new viruses or unknown viruses which are not fully researched, and can realize efficient and rapid propagation mode identification.

The invention relates to the substances benfo-oxythiamine and / or oxythiamine for use as the active ingredient of a topically administered medicament for the therapeutic treatment of patients with a disease of the body surface skin (cutis and subcutis) and / or one or more mucous membranes (mucosa) caused by viruses. The medicament is administered at a time when viral replication has already taken place and viral release from the host cell(s) is imminent.Benfo-oxythiamine and / or oxythiamine cause (I) a slowing or prevention of the spread mechanisms of the viruses, so that the viruses remain in their host cells after replication and cell damage in the patient organism (host organism) is reduced or prevented, and (II) an immune response against the viruses remaining in the cells, so that the patient's immune system is activated or reactivated to generate an effective immune response against the viruses.

The utility model provides a disposable sterile protective cover. The disposable sterile protective cover comprises a main body assembly and a fixing assembly, the main body assembly comprises a cover body, a flexible bottom edge is arranged at the bottom of the cover body, a supporting frame is arranged on the inner wall of the cover body, a pair of operation openings are formed in one end of the cover body, rubber gloves extending towards the interior of the cover body are arranged at the operation openings, an air inlet and an air outlet are further formed in the cover body, and one-way valves are arranged at the air inlet and the air outlet. A window is further formed in the cover body, a protective sticker is adhered to the window, and a connecting assembly aiming at an infusion tube is arranged on the cover body close to the window in a penetrating manner; the fixing assembly comprises a hard frame, the top of the hard frame is provided with a first bonding layer used for being bonded with the flexible bottom edge, and the bottom of the hard frame is provided with a second bonding layer used for being bonded with a sickbed. The disposable sterile protective cover provided by the utility model can effectively isolate an infectious patient and effectively prevent virus transmission, is also convenient for medical personnel to nurse the patient, and is ingenious in structural design and easy to operate and use.

In the present invention, cyclic dinucleotides or their compositions are used as biological response modifiers to enhance the immune response of subjects with deficient immune systems, with a low or absent response to vaccine antigens, or with a deficient immune response to pathogens. The formulations of the present invention are capable of modifying the biological response in such a way as to eliminate the lack of response, resulting in the development of a high-avid immune response that prevents disease caused by infectious agents, particularly viruses with the ability to evade immune surveillance mechanisms and, consequently, suppress the induction of an effective, high-avid adaptive response.The present invention also comprises cyclic dinucleotide formulations, which can be administered alone, in combination with other biological response modifiers, or in vaccine formulations with antigens. The proposed invention further includes a method for preventing or treating acute respiratory infections, preventing disease severity, and blocking transmission by inducing an immune response at the point of entry (nasopharyngeal mucosa), preventing or reducing person-to-person transmission of pathogens / viruses in preventive vaccine formulations, as well as in formulations used for prophylaxis before and after exposure to acute respiratory infections.

The present application relates to compositions and methods for: (a) preventing or treating viral infections; and / or (b) preventing the transmission and / or spread of infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety that specifically binds to a virus, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating viral infections, preventing the transmission of a viral infection from an infected individual to a non-infected individual, and for preventing the spread of a viral infection within a population of individuals.

The invention relates to the technical field of plant propagation, in particular to a Lanzhou lily scale cuttage method. According to the method, virus transmission can be effectively reduced through combination of double disinfection and trichoderma biological control, the risk of soil-borne diseases is reduced, the qualified rate of commercial bulbs is increased, meanwhile, the cultivation period of the commercial bulbs can be greatly shortened through hormone optimization treatment of single scales and a film mulching drip irrigation technology, and the economic benefit is increased. Through double-film covering and precise water and fertilizer management, the irrigation cost can be effectively reduced, the fertilizer utilization rate can be increased, the yield per mu and the commodity ball optimization rate can be remarkably increased, comprehensive breakthrough is achieved in efficiency, cost and quality, and the method is suitable for large-scale planting and industrial upgrading requirements.

This item is a cover for a box-shaped livestock storage rack that has multiple storage spaces capable of accommodating livestock such as chickens. It is used to prevent the spread of viruses during disease control operations in the event of an outbreak of livestock infectious diseases such as avian influenza. The right and left sides of the cover are each provided with a zipper, one near the left edge and one near the right edge, extending from the bottom edge to near the top edge. As shown in the reference perspective diagram of the usage state, when both zippers are opened, the portion sandwiched between these zippers can be rolled up to expose the livestock storage rack, allowing for work on the rack, such as storing livestock. Each edge of the top surface of the cover is provided with a flap that protrudes outward, and this flap can be grasped to attach or detach the cover.

Embodiments of the present application provide a virus infection prediction method and device, electronic equipment and storage medium. The method comprises obtaining sewage samples of a plurality of preset monitoring sites, performing gene sequencing on the sewage samples of each monitoring site to obtain gene sequence data of each monitoring site, and performing virus concentration identification on the sewage samples of each monitoring site to obtain the virus concentration of each monitoring site; performing gene analysis on the gene sequence data of each monitoring site, and constructing a phylogenetic tree corresponding to the plurality of monitoring sites based on the gene analysis result; determining a virus transmission path based on the phylogenetic tree, and updating parameters of a virus infection model based on the virus transmission path; and performing infection prediction on the virus concentration of each monitoring site based on the parameter-updated virus infection model to obtain a virus infection trend. The method can provide virus infection prediction accuracy.

The utility model relates to the technical field of receiving devices, in particular to a vomit receiving device which comprises a box body assembly, the box body assembly comprises a base, the upper surface of the base is fixedly connected with a cabinet body, the upper surface of the cabinet body is fixedly connected with a handrail, the upper surface of the cabinet body is fixedly connected with a flushing assembly, and the flushing assembly comprises a wash basin. The wash basin is fixedly connected with the upper surface of the cabinet body, the lower surface of the wash basin is fixedly connected with a sewer pipe, the upper surface of the cabinet body is fixedly connected with a faucet, the other end of the sewer pipe is fixedly connected with a water pump, the dirt receiving assembly comprises a placing frame, and one side of the placing frame is fixedly connected with a support. According to the vomitus cleaning device, the risk of pathogen and virus transmission is reduced, the health of patients and medical staff is protected, the wash basin and the faucet enable the patients to conveniently clean the oral cavity and the face after vomiting, more comfort is provided, discomfort and psychological stress after vomiting are reduced, and vomitus can be directly collected and treated due to the existence of the wash basin.

In the present invention, a cyclic dinucleotide or a composition thereof is used as a biological response modulator to improve an immune response in a subject having a low immune system function, a low / no response to a vaccine antigen, or a poor immune response to a pathogen. The formulations of the present invention are able to alter biological responses in a manner that eliminates non-responsiveness, thereby producing a high affinity immune response to prevent diseases caused by infectious agents, in particular viruses, which have the ability to evade the immune surveillance mechanism and thus inhibit the induction of high affinity and efficient adaptive responses. The invention also includes formulations of cyclic dinucleotides that can be administered alone, in combination with other biological response modulators, or in antigen-containing vaccine formulations. The proposed invention also includes methods of preventing or treating acute respiratory infections, preventing disease severity and blocking propagation by inducing an immune response at the entry site (nasopharyngeal mucosa), whether in a prophylactic vaccine formulation or in a formulation for prophylaxis before / after exposure of acute respiratory infections, and pathogen / virus transmission between people can be prevented or reduced.

The utility model provides a straw booster which comprises a sleeve, drag hooks, a straw and an outer package, the drag hooks are arranged on the sleeve, the sleeve is connected with the straw in a sliding mode, the sleeve where the straw is inserted is arranged in the outer package, the drag hooks are symmetrically arranged on the two sides of the sleeve, the outer sides of the drag hooks are open, and the drag hooks are vertically arranged in the middle of the sleeve. The sleeve and the draw hooks are integrally formed, are made of plastic materials, are stable in structure and light in weight, and can be made of hard food-grade plastic such as PET (polyethylene terephthalate), PP (polypropylene) and the like, during use, an opening of an outer package is torn off, the tip of the straw is inserted into a beverage, the index finger and the middle finger of one hand respectively extend into the draw hooks on two sides of the sleeve, and then the thumb presses the flat end of the straw, so that the beverage can be sucked out. The straw and the sleeve move relative to each other until the straw completely enters the beverage, the hand is not in direct contact with the straw in the whole process, the probability that bacteria or viruses on the hand are spread to the straw is greatly reduced, and a powerful guarantee is provided for use safety of people.

The invention discloses an HIV patient intelligent administration compliance management system, which comprises an intelligent sensing layer, a data processing layer and an application service layer, and realizes data interaction through an Internet of Things (IoT) communication protocol (preferably Bluetooth 5.0, NB-IoT). The system is used for solving the problems of self-report deviation, dependence on active operation, lack of drug storage monitoring and insufficient privacy protection in HIV patient administration compliance management. Through the comprehensive action of the technical effects, the drug administration compliance rate of the HIV patient can be remarkably improved: on one hand, the conditions of missing taking, wrong taking and invalid taking of drugs are reduced through accurate monitoring and dynamic reminding; on the other hand, the problem of compliance caused by side effects, scene changes and the like can be solved in time through personalized intervention of medical staff based on real data, the risk of virus drug resistance is reduced, the long-term treatment effect of patients is finally improved, the disease deterioration and virus propagation probability is reduced, and the method has important clinical application value and public health significance.

The invention discloses an application of cis-BBP in inactivation of viruses with envelope structures. Any one of the following applications of the cis-BBP comprises an application of the cis-BBP in photodynamic inactivation of the virus with the envelope structure, an application of the cis-BBP in preparation of a product for preventing and treating the virus with the envelope structure, and an application of the cis-BBP in preparation of a product for inhibiting cells infected by the virus with the envelope structure. According to the application of the cis-BBP in photodynamic inactivation of the virus with the envelope structure, the antiviral efficiency is high, and a broad-spectrum antiviral strategy for the virus with the envelope structure is developed. The broad-spectrum antiviral ability of the cis-BBP is explored by utilizing the characteristics of the cis-BBP, and the action effect of the cis-BBP on various viruses is clarified. The cis-BBP shows antiviral activity and excellent biocompatibility in vivo. When applied to transportation and packaging, it shows significant potential in controlling virus propagation.

The utility model discloses a bag folding, heat sealing and fusing device of an intelligent medical waste collecting robot. The bag folding, heat sealing and fusing device comprises a left double-thread screw, a right double-thread screw, a front hot melting tool apron, a rear hot melting tool apron and a synchronous rotation driving mechanism. When the garbage collection bag folding and stacking device is used for folding and stacking garbage collection bags, the folding positions of the garbage collection bags can be smoother, the number of stacked layers is reduced, the problems of fusing and adhesion are avoided, and the sealing performance of heat sealing is ensured, so that the requirement for the thickness of the garbage collection bags is reduced, and the garbage collection bag folding and stacking device is suitable for garbage collection bags with various thicknesses; particularly, the garbage collection bag with the thickness of 20-50 microns meets the collection requirement of the medical garbage, secondary pollution of the medical garbage and virus propagation and diffusion are prevented, and finally wide application of the intelligent medical garbage collection robot can be facilitated.

The invention discloses application of dextran sulfate sodium in preparation of a medicine for treating and preventing human papilloma virus infection. According to the application, the action effect of the dextran sulfate on inhibiting human papilloma virus type 6, type 16, type 18 and type 58 pseudoviruses from entering 293FT cells is evaluated at the cellular level, and the result shows that the dextran sulfate can effectively inhibit the human papilloma virus type 6, type 16, type 18 and type 58 from infecting the 293FT cells. Results of inhibition of human papilloma virus 16 pseudovirus infection by sodium dextran sulfate according to animal level evaluation show that sodium dextran sulfate can effectively inhibit infection of human papilloma virus 16 pseudovirus on mouse genitals. Sodium dextran sulfate has the advantages of blocking HPV virus from invading cells, preventing virus from expanding infection, being safe, stable, low in cost and the like, and the medicine has the prospect of being developed into a preparation for treating or preventing human papilloma virus infection related diseases.

The utility model discloses a POS machine capable of scanning codes and paying, which belongs to the technical field of POS machines and comprises a protective box and a box cover, the box cover is mounted on one side of the protective box in a hinged manner, a POS machine body is fixedly mounted in the protective box, a code scanning camera is arranged on the POS machine body and extends to the outside of the protective box, a shielding assembly is mounted at the lower end of the outside of the protective box, and the shielding assembly is connected with the protective box. The shielding assembly is located on one side of the code scanning camera, the disinfection assembly is installed in the box cover, the lock catch is fixedly installed in the other side of the box cover, the box cover is connected with the protection box through the lock catch, code scanning payment can be completed through the code scanning camera on the POS machine body, and meanwhile the code scanning camera can be shielded through the shielding assembly when the POS machine is not used. And the POS machine body can be disinfected through the disinfection assembly after the POS machine is used, so that bacterial residues are reduced, the occurrence of virus spreading conditions is reduced, and the use safety of a user is improved.

According to some embodiments, a carrier for reducing a likelihood of a pathogen binding to cell structures of a host comprises a core, surface features extending from an exterior surface of the core, wherein the surface features are configured to bind to target areas of cell structures of the host to at least partially block the pathogen from binding to said target areas as a result of competitive inhibition, and a plurality of binding sites along the exterior surface, wherein the binding sites are configured to attract at least one portion of the pathogen, wherein the binding sites are recognizable by the pathogen and are able to be bound by the pathogen, thereby at least partially immobilizing the pathogen and reducing the likelihood of the pathogen binding to target areas of cell structures of the host.

The present application relates to compositions and methods for: (a) preventing or treating viral infections; and / or (b) preventing the transmission and / or spread of infections. In some embodiments, the present application provides chimeric proteins comprising a target-binding moiety that specifically binds to a virus, and a positively charged mucoadhesive peptide fragment. Compositions comprising the chimeric proteins described herein are useful for preventing or treating viral infections, preventing the transmission of a viral infection from an infected individual to a non-infected individual, and for preventing the spread of a viral infection within a population of individuals.

To provide novel antiviral treatments, pharmaceutical products, and chemicals that can be used to prevent viral infection and / or viral spread in subjects exposed to, infected with, or at risk of viral infection. [Solution] An azelastine compound in an antivirally effective amount for use as an antiviral substance in a pharmaceutical formulation.

Aspects of the present disclosure relate to a method of preventing transmission of an enveloped RNA virus. The method includes applying to a mucosal tissue of a first mammalian subject not substantially colonized by the enveloped RNA virus an effective amount of an antiseptic composition or a pharmaceutically acceptable salt thereof according to a treatment plan. The first mammalian subject not substantially colonized by the enveloped RNA virus interacts with a second mammalian subject colonized by the enveloped RNA virus at a first viral load, the first mammalian subject has a second viral load based on the interaction, the second viral load is no greater than 0.5 log increase over an initial viral load over a duration of the treatment plan. The mucosal tissue is in the nasopharynx, nasal cavity, or anterior nares of the mammalian subject. The antiseptic composition comprises iodine, iodophor, or combinations thereof.