10 results about "Virus transmission" patented technology

The application provides a dengue virus protection and mosquito vector control antigen composition and application thereof. The antigen composition comprises a combination of dengue virus type 1-4 envelope protein domain III polypeptide and Aedes aegypti midgut mucin AaMuc1 antigen polypeptide; the amino acid sequences of the dengue virus type 1-4 envelope protein domain III polypeptide are respectively shown as SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3 and SEQ ID NO. 4; and the amino acid sequence of the Aedes aegypti midgut mucin AaMuc1 antigen polypeptide is shown as SEQ ID NO. 5. The prepared vaccine can induce the body to produce neutralizing antibodies against dengue virus type 1-4, achieve the protection of human body from dengue virus infection, induce the production of active antibodies targeting Aedes aegypti midgut mucin 1, inhibit and kill the dengue virus transmission vector Aedes aegypti, and achieve the dual prevention and control of dengue fever from two dimensions of infection prevention and transmission interruption.

This utility model discloses a positive and negative pressure switching fresh air system, comprising: an intake fan connected to an air distribution box via pipes, the air distribution box connected to the intake valves of each room via pipes and silencers; a return fan connected to a collection box via pipes, the collection box connected to the return air valves of each room via pipes; when the intake fan is turned on and all the intake and return air valves of all rooms are fully open, all rooms are in a positive pressure state; when the return fan is turned on and all the intake and return air valves of all rooms are fully open, the return air volume is greater than the intake air volume, and all rooms are in a negative pressure state; when both the intake and return air fans are fully open, if room 1 opens its intake valve and closes its return air valve, room 1 is in a positive pressure state; if room 2 opens its return air valve and closes its intake valve, room 2 is in a negative pressure state; positive pressure rooms prevent virus intrusion, and negative pressure rooms prevent virus spillover; infected individuals live in negative pressure rooms, and uninfected individuals live in positive pressure rooms, which can prevent cross-infection among family members and is very suitable for the current virus transmission situation.

The application discloses a tomato Soly04g076730 Gene or its encoded protein is applied to resisting plant geminivirus. Soly04g076730 The gene is transiently expressed or stably genetically transformed in a plant leaf. When a virus invades the plant, the plant immune response is rapidly induced, and the disease resistance of the plant is improved. The Soly04g076730 protein is a secretory protein. The plant immune ability can be improved by expressing or externally applying the protein in the plant, and the virus transmission and replication can be effectively inhibited.

This utility model discloses an elevator call device based on Time-of-Flight (ToF) technology, belonging to the field of elevator control equipment technology. It includes a housing with a sensor window extending through its front end and a projection window extending through its front end near the upper edge. This utility model, through the cooperation of a projection display module and a ToF sensor module, fundamentally eliminates direct contact between the user and the device surface using non-contact ToF technology. Compared to traditional contact-based elevator call devices, it effectively reduces the transmission routes of bacteria and viruses, significantly lowering the risk of cross-infection between patients. In places with high population mobility, it provides users with a safer and healthier elevator environment, meeting the growing demand for public health and safety.

The application discloses a network virus propagation prediction and defense method and system, and belongs to the technical field of network security. The method constructs a dynamic infection state graph dataset indexed by time, each time step containing a node security attribute feature matrix and an infection state sequence; a spatial feature matrix is extracted through a graph attention network, and a global time feature matrix is extracted through a Transformer encoder; the global time feature is used as a query vector, and the spatial feature is used as a key-value pair, which are weighted and aggregated through a cross-attention mechanism to obtain a fusion feature matrix, and an infection state prediction result is mapped and output; the security attributes and topological context features of high-risk nodes in the prediction result are extracted and mapped into query vectors, enhanced knowledge is retrieved from an external knowledge base based on the query vectors, prediction information, security attributes, topological contexts and enhanced knowledge are input into a large language model to generate an active defense strategy, and an automatic closed loop from virus propagation prediction to active defense is realized.

This invention discloses the application of an endogenous Bunyavirus element LsBuEVE and its dsRNA from the planthopper in blocking the transmission of rice viruses. The LsBuEVE genome contains the nucleotide sequence shown in SEQ ID NO.1, and its corresponding transcript contains a complete open reading frame, the nucleotide sequence of which is shown in SEQ ID NO.2, and the encoded amino acid sequence is shown in SEQ ID NO.3. Introducing the dsRNA targeting LsBuEVE into the planthopper effectively inhibits LsBuEVE expression, significantly reduces the transcriptional level of the RSV nucleoprotein gene, protein accumulation, and the RSV acquisition rate in the planthopper, thereby effectively blocking RSV replication and transmission within the planthopper. This invention reveals for the first time the important role of the endogenous viral element LsBuEVE in the transmission of plant viruses by vector insects and provides a precise targeted control strategy based on RNA interference. Compared with traditional chemical pesticides, this technology has advantages such as high specificity, environmental friendliness, and low likelihood of developing resistance, and has broad application prospects and commercial value.

This invention relates to the field of traditional Chinese medicine compound preparations, specifically to a traditional Chinese medicine compound nasal spray with both rapid-release and sustained-release effects, its preparation method, and its application. The preparation method of the traditional Chinese medicine compound nasal spray with both rapid-release and sustained-release effects includes the following steps: Step S1: Preparing the traditional Chinese medicine compound composition into a microemulsion solution; the traditional Chinese medicine compound composition contains volatile oils; Step S2: Making the microemulsion solution to volume with distilled water, then adjusting the osmotic pressure with sodium chloride solution, and adjusting the pH with hydrochloric acid solution. This invention combines rapid and long-lasting effects. One-fifth of the traditional Chinese medicine compound composition in the nasal spray has a rapid-release effect, and its rapid-release mechanism can produce a protective effect the moment the virus invades the nasal cavity; while the four-fifths of the drug sustained-release microspheres in the spray have a long-lasting mechanism, which can prolong the drug's action time, fully adapting to the "time-limited characteristic" of influenza virus transmission up to 48 hours, filling the gap in current similar nasal sprays that lack sustained-release effects.

This application provides a method and related equipment for determining regional viral evolution trends based on wastewater sequencing. The method includes determining the viral evolution rate based on multiple first target viral lineages and their abundance, as well as multiple second target viral lineages and their abundance; performing risk analysis on predetermined target viruses present in multiple first water samples based on multiple target viral mutation site information to obtain viral transmission risk; determining the change in the immune level of the population in the predetermined target area against the predetermined target viral lineage based on infection distribution data and neutralizing antibody titer data for each immune source to obtain the prediction result of the dominant lineage succession of the viral lineage over time; and using the viral evolution rate, viral transmission risk, and the prediction result of the dominant lineage succession of each viral lineage over time as the viral evolution trend information corresponding to the predetermined target area, thus solving the technical problem that the determination of regional viral evolution trends in the prior art is inaccurate.

The application discloses a kind of infectious disease network key node identification method based on graph neural network, comprising the following steps: 1, by traditional SIR infectious disease model on the generated network simulates virus transmission process, constructs training data label;2, select the highest score of Kendall coefficient and the score obtained in step 1 is combined with feature, the selected network features are input into the attention model with multiple graph attention layers are introduced, in a variety of artificial networks are trained, to obtain the importance score ranking of each node more suitable;3, consider the "rich club" effect, the obtained ranking sequence is selected by the node selection algorithm based on distance 2-hop, select the node set that the influence range is further expanded.The application provides a new idea and tool for key node identification in complex network, and provides a scientific basis for network optimization and risk prevention.

This invention provides a method for preparing a composite solution of sodium hyaluronate and recombinant type III humanized collagen. The invention utilizes artificial screening and design to obtain recombinant type III humanized collagen COL3A1-QS-1, which is highly efficient in secretion and expression in Pichia pastoris. Compared with animal-derived collagen, it has advantages such as uniform molecular weight, high purity, no risk of viral transmission, low rejection reaction, and high bioactivity. Sodium hyaluronate absorbs water and swells into a gel, physically filling tissue volume loss and thus achieving the effect of filling wrinkles and smoothing fine lines. Recombinant type III humanized collagen provides a scaffold and favorable microenvironment for cells, promoting cell adhesion, proliferation, growth, migration, and support for cells and tissues. The composite solution of sodium hyaluronate and recombinant type III humanized collagen prepared from these two components stimulates collagen production by improving the local internal environment, thereby improving superficial wrinkles.