Tablet capsule for treating helicobacter pylori infection

A technology of capsules and tablets, applied in capsule delivery, medical preparations containing active ingredients, digestive system, etc., can solve the problems of reducing effects, increasing side effects, and difficult to accurately quantify ingredients, so as to improve stability and increase compliance , the effect of enhancing compliance

Inactive Publication Date: 2009-11-25
HEILONGJIANG FUHE HUAXING PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Although the above-mentioned technical scheme realizes taking all the drugs in the triple or quadruple therapy together, if the bismuth potassium subcitrate and metronidazole granules are packed in the middle of the inner and outer capsules, the two active ingredients may have a pharmaceutical compatibility reaction , which is detrimental to the stability
In addition, in drug testing, each active ingredient cannot be measured separately, which increases the complexity of the test
[0012] Because if the active ingredients are in contact with each other, there are the following disadvantages: 1. Due to the influence of multi-component mixing uniformity, it is difficult to accurately quantify each component; 2. During product testing, it is difficult to determine the content of each component due to mutual interference, which affects the qualitative and quantitative analysis results; 3. During long-term storage, due to possible chemical compatibility changes among the components, by-products are likely to be produced, reducing the effect or increasing side effects, and the product stability is not ideal

Method used

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  • Tablet capsule for treating helicobacter pylori infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Capsules containing tinidazole tablets, bismuth potassium citrate tablets and clarithromycin tablets were prepared. The process is as follows:

[0061] 1. Tinidazole tablets (100 tablets) were prepared by wet granulation

[0062] components

Weight (g)

Tinidazole

12.5

dry starch

2.5

15% starch slurry (contains starch)

2

Low-substituted hydroxypropyl cellulose

2.5

Magnesium stearate

0.5

total

20

[0063] a. 12.5g tinidazole is mixed with 2.5g dry starch and 2.5g low-substituted hydroxypropyl cellulose;

[0064] b. Make 15% starch slurry from 2g of starch and add it to a, mix well;

[0065] c. After the mixture b is passed through a 16-mesh sieve, after granulation, add 0.5g magnesium stearate and mix;

[0066] d. The final mixture is compressed into tablets, and the theoretical tablet weight of each tablet is 200 mg;

[0067] e. Coat the obtained tablet with a high-effic...

example 2

[0085] Preparation of capsules containing lansoprazole tablets, amoxicillin tablets and clarithromycin tablets

[0086] 1. the preparation of lansoprazole sheet (100)

[0087] components

Weight (g)

Lansoprazole

0.75

lactose

6.75

microcrystalline cellulose

7

Low-substituted hydroxypropyl cellulose

2

Magnesium stearate

0.5

Povidone K30

1.5

Carboxymethyl Starch Sodium

1.5

total

20

[0088] a. Mix 6.75g of lactose and 7g of microcrystalline cellulose evenly, and pass through a 80-mesh sieve;

[0089] b. Mix a with 0.75g lansoprazole and 2g low-substituted hydroxypropyl cellulose evenly, make a solution of 1.5g povidone K 30 with an appropriate amount of absolute ethanol, use it as a binder, and pass through a 30-mesh sieve Granules, dried at 50°C, passed through a 30-mesh sieve for granulation;

[0090] c. Add carboxymethyl starch sodium and magnesium ste...

example 3

[0104] Preparation of capsules containing metronidazole tablets, tetracycline tablets, bismuth potassium citrate tablets

[0105] 1. prepare metronidazole sheet (feeding amount is the consumption of 100) with wet granulation method

[0106] components

Weight (g)

Metronidazole

12.5

dry starch

3.5

15% starch slurry

2

Low-substituted hydroxypropyl cellulose

2.5

Magnesium stearate

0.5

total

21

[0107] a. Mix 12.5g metronidazole with 3.5g dry starch and 2.5g low-substituted hydroxypropyl cellulose;

[0108] b. Add 15% starch slurry to a and mix well;

[0109] c. After passing the mixture b through a 16-mesh sieve, add 0.5g magnesium stearate and mix;

[0110] d. The final mixture is compressed into tablets, and the theoretical tablet weight of each tablet is 210 mg;

[0111] e. Package ordinary film coating (black)

[0112] 2. Prepare bismuth potassium citrate tablets with wet gr...

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Abstract

The invention relates to an oral hard capsule, in particular to an oral hard capsule filled with different medicament active ingredient tablets and used for treating infection caused by helicobacter pylori. The technical scheme is realized in such a way that tablets containing antibiotics and wrapping enteric coating, soluble salt tablets of bismuth and / or gastric acid depressant tablets are filled into a capsule, thereby providing an administration dosage form which has simpler preparation process and can enable all the medicaments to be beautifully taken by a trilogy / quadruple chemotherapy. The active ingredients with the dosage form do not contact mutually, thus different active ingredients can be separately measured in medicament detection.

Description

technical field [0001] The invention relates to an oral hard capsule, in particular to an oral hard capsule filled with tablets of different pharmaceutical active ingredients, and the capsule is used for treating infection caused by Helicobacter pylori. Background technique [0002] Helicobacter is a microaerophilic Gram-negative bacterium, belonging to the family Helicobacteriaceae. It consists of an active spiral-shaped bacterium and several sheathed flagella. Helicobacter pylori (Hp) is a very common bacterium that infects nearly half of the world's population and can cause digestive system diseases, such as gastritis and peptic ulcer, with a high infection rate in developing countries. [0003] In 2005, "Clinical Guidelines for Helicobacter Pylori Infection in Developing Countries" published at the 13th World Congress of Gastroenterology (URL: http: / / www.worldgastroenterology.org / assets / downloads / cy / pdf / guidelines / g_data15_ch.pdf) states that H. pylori eradication can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K45/06A61K33/24A61P1/04
Inventor 吴光彦吴玉山王景昆章小炎王玉松
Owner HEILONGJIANG FUHE HUAXING PHARMA GROUP
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