51 results about "Stomach fluid" patented technology

The invention relates to the technical field of data management, in particular to a self-service enema method and system based on intelligent proportioning, and the method comprises the following steps: collecting intestinal tract and physiological data, monitoring intestinal tract movement frequency, intestinal wall tension, instantaneous pressure, digestive juice secretion rate, heart rate and blood pressure in real time, removing abnormal data, and adjusting the data range. And forming a physiological parameter data set. According to the method, a refined data set is constructed by monitoring multiple physiological data in real time, so that the liquid medicine proportion better conforms to the individual characteristics, flow rate correction and pressure adjustment are introduced in the liquid medicine mixing process, it is ensured that the proportion is accurate and liquid medicine conveying is stable, and real-time pressure monitoring and excrement flow state analysis help to optimize the conveying rate and improve the liquid medicine absorption efficiency; the influence of individual difference is reduced, so that the accuracy and the effect of treatment are enhanced.

The invention discloses Pediococcus pentosaceus G41, which is separated from rumen fluid of healthy adult dairy cows in a certain cattle farm in Changchun, has the advantages of high growth speed and strong acid production capacity, and can effectively relieve cholestatic liver injury. Experiments prove that the Pediococcus pentosaceus G41 reduces the activity of serum AST, ALT and GDH of a mouse with cholestatic liver injury, reduces the content of total bile acid in blood and liver, increases the content of total bile acid in excrement, and improves cholestatic and dirty injury caused by cholestatic.

The present invention provides a material or method that can replace conventional materials and methods for preventing digestive fluid leakage. The digestive fluid leakage preventing material of the present invention comprises a self-assembling peptide gel, has an adhesion retention rate of at least 40% on a collagen sheet, and a decomposition rate of 35% or less based on pancreatic juice treatment at 37°C for 7 days.

The invention relates to the technical field of livestock breeding improvement, and discloses a beef cattle high intramuscular fat content prediction method and application. The beef cattle high intramuscular fat content prediction method comprises the following steps: step 1, obtaining a rumen fluid sample of beef cattle to be detected; step 2, detecting the contents of myristic oleic acid, citric acid and salicylate in the rumen fluid sample; and step 3, comparing the content with a preset threshold value, and if the content of at least one metabolite is higher than the corresponding preset threshold value, predicting that the beef cattle has high intramuscular fat deposition potential or high intramuscular fat content. According to the method, early-stage, rapid and accurate prediction of the high intramuscular fat deposition potential of the individual cattle can be realized, the limitation that the traditional method depends on post-slaughter phenotype determination or is long in gene breeding period and high in cost is overcome, and a brand new technical means is provided for early-stage seed selection and precise breeding.

The invention provides a preparation method of a yak rumen fluid fermented feed. The method comprises the following steps: selecting rumen fluid suitable for high-concentrate barn feeding daily ration yaks; putting the rumen fluid into a fermentation container filled with feed, and uniformly stirring to form a rumen fluid and feed mixture; and adjusting the pH value of the rumen fluid feed mixture to 6.9-7.3 by using water, adjusting the temperature of the rumen fluid feed mixture to 38.5-39.5 DEG C, adjusting the ratio of water to feed to 1: 1-1.4: 1, and performing post-fermentation for 12-48 hours to obtain the yak rumen fluid fermented feed. According to the yak rumen fluid fermented feed disclosed by the invention, by promoting an L-threonine metabolic pathway, inhibition of excessive tryptophan on growth is slowed down, and the feed intake is increased. The feed also can enhance the metabolic capability of yaks, generate keratinous sulfuric acid and hyaluronic acid, and protect the body. By using the feed, the average and total weight gain of yaks can be remarkably improved, the feed-to-weight ratio is reduced, and the breeding economic benefit is improved.

The present disclosure relates to ganaxolone derivatives, as well as methods of using the compounds (e.g., for treating a disease or disorder), methods of making the compounds, and pharmaceutical compositions and kits containing the same. The present disclosure relates to ganaxolone derivatives. The compounds disclosed herein can be metabolized (e.g., in vivo, e.g., by metabolic processes) to ganaxolone. The compounds disclosed herein are also more soluble than ganaxolone in aqueous solutions, such as plasma, gastric fluid, or intestinal fluid. Also disclosed herein are methods of using the compounds, methods of making the compounds, and pharmaceutical compositions and kits containing them.

The present invention provides a self-assembling peptide gel for use in preventing a leak of digestive fluid and a self-assembling peptide gel for use in protecting an organ against digestion by a digestive fluid. The self-assembling peptide gel comprises a self-assembling peptide and water, whereby the self-assembling peptide gel has an adhesion persistence ratio with respect to a collagen sheet of at least 40% and a decomposition ratio of 35% or less in pancreatic juice treatment at 37°C for 7 days, and the self-assembling peptide gel is positively charged as a whole.

The present invention provides a material or method that can serve as an alternative to a related-art digestive fluid leak preventative material and method of preventing a leak of a digestive fluid. The digestive fluid leak preventative material of the present invention includes a self-assembling peptide gel, has an adhesion persistence ratio with respect to a collagen sheet of at least 40%, and has a decomposition ratio of 35% or less in pancreatic juice treatment at 37°C for 7 days.

The present invention discloses a method of enabling a better and more controlled drug release from an oral administered pill and / or an oral delivery device by using gravity adding weight / high density content to secure that the pill / device decent through the stomach fluids and come in close contact with stomach and / or intestine tissue as it dissolves / releases the drug enabling a better controlled absorption / transfer of the drug to the blood stream.

The invention discloses a method for producing hydrogen through rumen microorganism fermentation, and relates to the technical field of resources and environment. Comprising the following steps: inoculating fresh rumen fluid into a fermentation tank filled with a buffer solution according to a volume ratio of 5-10%, and after 24-36 hours, adding 10-30 g / L of biomass waste to start a fermentation reaction. When the content of H2 in a gas production component reaches 20%, the fermentation temperature is controlled to be 37-40 DEG C, the HRT is controlled to be 50-90 h, the SRT is controlled to be 6-10 d, the pH is controlled to be 5.5-6.0, biomass waste is added according to 1-3 g / L.d, the headspace pressure is kept to be 95 + / -5 kPa, and the system starts to continuously feed and discharge materials and feed and discharge water to produce hydrogen through fermentation. According to the method, cellulose biomass is used as a substrate, the hydrogen production amount is increased by 50-100% compared with that of a traditional anaerobic biological dark hydrogen production method, the retention time is shortened by 3-10 days, the hydrolysis, saccharification and hydrogen production processes can be achieved in the same reactor, and the production cost is reduced.

This invention belongs to the field of food nutrition and functional factors, specifically relating to a method for preparing highly immunomodulatory ovotransferrin (OVT) hydrolysates based on an adult gastrointestinal simulated digestive system. The method involves processing OVT using a simulated adult gastrointestinal tract to prepare OVT hydrolysates containing HTEGSTT, TTSY, and / or RTAGWVIPMG. This invention reveals that OVT exhibits enhanced immunomodulatory activity after gastrointestinal digestion and hydrolysis, and is more readily hydrolyzed in simulated adult digestive fluids than in infant digestive fluids. Comparative experiments show that nutritional intervention with OVT simulated digestive products from adults and infants can promote the production of short-chain fatty acids such as acetic acid, propionic acid, and butyric acid, effectively alleviate swelling and damage to the small intestinal mucosa caused by inflammation, significantly improve intestinal barrier immune function, and OVT IA exhibits higher intestinal immune activity than OVT IB.

The pediatric gastric lavage device comprises a liquid storage tank, a stirring and heating mechanism, an air cylinder, a waste liquid tank, an outer hose, an electric heating layer, an inner hose, a cleaning mechanism, a recycling mechanism and a rubber ball, the liquid storage tank is arranged on the rear side of the upper portion of a bottom plate, the stirring and heating mechanism is arranged in the liquid storage tank, and the waste liquid tank is arranged on the upper portion of a mounting plate; the electric heating layer is fixedly connected to the inner side of the outer hose, the cleaning mechanism is arranged between the outer hose and the liquid storage tank, and the recycling mechanism is arranged between the outer hose and the waste liquid tank. Compared with the prior art, the gastric lavage device has the advantages that normal saline and medicine in the liquid storage box can be fully stirred and mixed through the stirring and heating mechanism, the uniformity and the using effect of gastric lavage liquid are guaranteed, and meanwhile the heating bin is arranged to be matched with the electric heating pipe to heat liquid in the liquid storage box; the flushing is milder, and the stomach of the child cannot be stimulated.

The invention belongs to stomach tubes, and particularly relates to a neonatal tube feeding and drainage integrated device which comprises a middle tube body composed of a first channel and a second channel which are independent from each other. The external joint comprises a first joint and a second joint; the far-end connector covers the ends of the first channel and the second channel, one end of the first channel is communicated with the interior of the far-end connector, the other end of the first channel is communicated with the first connector, one end of the second channel is communicated with the interior of the far-end connector, and the other end of the second channel is communicated with the second connector. The first channel and the second channel on one side of the external joint are not communicated with each other so as to avoid flow path interference; the far-end connector and the channel are provided with a first through hole and a second through hole which are used for being communicated with a gastral cavity. The state switching sealing assembly is arranged, so that the device closes the second channel in the first state so as to achieve stomach gas discharge during feeding, the first channel and the second channel are communicated in the second state so as to achieve gastric juice suction, the risks of abdominal distension, backflow and aspiration are reduced, and state switching is simple, rapid and effortless.

The utility model relates to the technical field of gastrointestinal department medical instruments, in particular to a digestive juice filtering and reinfusion device which comprises a shell, an input pipe and an output pipe, the input pipe and the output pipe are communicated with the interior of the shell, a filter plate and a partition plate are arranged in the shell to divide the interior of the shell into an input cavity, a middle cavity and a reinfusion cavity in sequence, and the input cavity is communicated with the input pipe. The middle cavity is communicated with the output pipe, the middle cavity is externally connected with a negative pressure device, the partition plate is provided with a valve, the valve has an opening state and a closing state, when negative pressure is formed in the middle cavity, the valve maintains the closing state, and when hydraulic pressure in the middle cavity is larger than acting force needed by closing of the valve, the valve is opened so that the middle cavity and the feedback cavity can be communicated. The problems that an existing digestive juice filtering and returning device is relatively complex in structure and relatively troublesome to use are solved.

The invention relates to a method for measuring the release rate of each site of a ruminant rumen bypass product, which comprises the following steps: measuring the water solubility: weighing a proper amount of rumen bypass sample, and measuring the water solubility; measuring the acid solubility: weighing a proper amount of rumen bypass sample, and measuring the acid solubility; rumen degradation rate determination: weighing a rumen bypass sample after water solubility determination and / or acid solubility determination, putting the rumen bypass sample on a feed, adding a buffer solution and rumen fluid for in-vitro fermentation, after fermentation is finished, performing constant-temperature drying, then performing weighing, and performing rumen degradation rate determination; measuring the abomasum degradation rate: weighing the rumen bypass sample after the rumen degradation rate measurement, adding a hydrochloric acid buffer solution of pepsin for constant-temperature culture, taking out the rumen bypass sample after the culture is finished, drying at constant temperature, weighing, and measuring the abomasum degradation rate; and small intestine degradation rate determination: taking the rumen bypass sample after abomasum degradation rate determination, adding a small intestine buffer solution, carrying out shake culture, cleaning, drying at a constant temperature, weighing, and determining the small intestine degradation rate.

The present invention discloses a method and application for encapsulating tributyrin with a hydrophilic barrier layer to aid probiotics in encapsulating tributyrin, belonging to the field of oil microencapsulation technology. The method comprises the following steps: 1) mixing probiotic cells with tributyrin and washing with an aqueous solution to obtain a first complex containing probiotics encapsulating tributyrin; and 2) mixing the first complex with a hydrophilic solution to obtain a second complex containing probiotics encapsulating tributyrin with a hydrophilic barrier layer. The second complex (tributyrin-encapsulated complex) prepared using the present method exhibits high loading capacity, lacks surface oil, and completely masks the odor of tributyrin. It can release tributyrin in digestive fluids and exert intestinal health benefits. It can be used in food, medicine, and feed, as well as in oral or parenteral formulations.

The application provides an article information pushing method combining article attributes and user preferences, comprising: obtaining digestive system disease types, digestive tract absorption capacity, digestive fluid secretion conditions and physiological characteristic data related to digestive function of a plurality of users, grouping the users through a clustering algorithm to obtain user groups with different digestive function characteristics; obtaining dosage form, particle size and surface area attribute information of health products, reducing the dimensions of the health products through principal component analysis according to disintegration time, dissolution rate and osmotic pressure characteristics of the dosage form to obtain a key attribute set of health products with different dosage forms; obtaining health product information searched by the user and digestive condition data of the user, and judging whether the user belongs to a group with weak digestive tract absorption capacity or a group with normal digestive function according to a set digestive threshold.

The invention provides a bionic stomach micro-fluidic chip based on liquid drop micro-fluidic control and mechanical force stimulation and application of the bionic stomach micro-fluidic chip. The bionic stomach micro-fluidic chip comprises a liquid drop generation module and a mechanical force stimulation module. The liquid drop generation module is used for dispersing artificial stomach digestive juice and a to-be-digested Newtonian fluid sample in an oil phase by utilizing a micro-fluidic chip structure to form monodispersed water-in-oil liquid drops to simulate a discrete chyme group; and the mechanical force stimulation module is provided with a micro-channel with a periodically variable cross section. When liquid drops flow through the flow channel, the liquid drops are extruded and deformed periodically, a complex flow field is generated in the liquid drops, and the mechanical kneading effect of stomach wall wriggling on chyme balls is simulated. By limiting biochemical reaction in micro-droplets and applying controllable physical shear force, collaborative high-fidelity simulation of chemical and mechanical effects in the gastric digestion process is realized, and the problems that a traditional static model is low in simulation degree and large dynamic equipment is low in flux and high in cost are solved. And a brand new high-throughput research platform is provided for the fields of food and medicine.

The invention discloses application of methyl nicotinate as a marker in evaluation of bull semen quality, and belongs to the technical field of animal reproduction and metabonomics. The relative content of methyl nicotinate in the bull rumen fluid with high semen quality is significantly higher than the relative content of methyl nicotinate in the bull rumen fluid with low semen quality. By detecting the relative content, the bull semen quality is evaluated, the reproductive performance can be reliably judged on the premise of not depending on a semen sample, and the method has the remarkable advantages of being non-invasive, high in throughput, capable of advancing a prediction window and the like.

The present invention relates to compositions in the form of PET- and lecithin-free microemulsion preconcentrates that contain at least one cannabinoid, at least one polyglyceryl- containing surfactant, at least one polyol and a preservative. When contacted with either an aqueous medium, gastric or intestinal fluid, the microemulsion preconcentrates self-assemble into microemulsions that are stable in gastric and intestinal fluids. The invention is also related to methods of making and methods of using the microemulsion preconcentrates.

This invention discloses the application of a nutritional composition in the preparation of immunomodulatory products. The nutritional composition comprises lactoferrin gastrointestinal digests and selenium gastrointestinal digests; wherein the content of lactoferrin gastrointestinal digests in the nutritional composition is 80-180 μg / mL; and the content of selenium gastrointestinal digests, calculated as selenium, is 12-28 ng / mL. The nutritional composition provided by this invention, comprising a digestive fluid of lactoferrin and selenium, exhibits a better synergistic anti-inflammatory effect compared to lactoferrin or selenium alone.

Disclosed in the present invention are a digestive fluid sampling tube and a sampling device. The digestive fluid sampling tube and the sampling device provided according to the embodiments of the present invention comprise a liquid collecting head, the liquid collecting head being provided with a liquid collecting opening; and a tube body, the tube body being provided with a liquid collecting channel, the liquid collecting channel communicating with the liquid collecting opening, and the outer diameter size of the tube body ranging from 1 mm to 5 mm. The digestive fluid sampling tube and the sampling device provided by the embodiments of the present invention use a sampling tube having a small outer diameter to achieve microsampling, thus lessening the pain in swallowing and dragging for patients and improving the tolerance of patients. In addition, the present invention can achieve accurate multi-site micro sampling, thereby improving diagnosis accuracy.

To provide a material or a method capable of replacing a conventional digestive fluid leakage preventing material and a conventional digestive fluid leakage preventing method.SOLUTION: The digestive fluid leakage prevention material of the present invention contains a self-assembling peptide gel, has an adhesion residual ratio of at least 40% with respect to a collagen sheet, and has a degradation rate of 35% or less when treated with pancreatic fluid at 37 °C for 7 days.SELECTED DRAWING: None

This invention relates to a method for determining the release rate at various points of a rumen-exposed product in ruminants, comprising the following steps: water solubility determination: weighing an appropriate amount of rumen-exposed sample and determining its water solubility; acid solubility determination: weighing an appropriate amount of rumen-exposed sample and determining its acid solubility; rumen degradation rate determination: weighing the rumen-exposed sample after water and / or acid solubility determinations, placing it on feed, adding buffer solution and rumen fluid for in vitro fermentation, drying at a constant temperature after fermentation, weighing, and determining the rumen degradation rate; abomasal degradation rate determination: weighing the rumen-exposed sample after rumen degradation rate determination, adding pepsin hydrochloride buffer solution for incubation at a constant temperature, removing and drying at a constant temperature after incubation, weighing, and determining the abomasal degradation rate; small intestinal degradation rate determination: taking the rumen-exposed sample after abomasal degradation rate determination, adding small intestinal buffer solution for shaking incubation, washing, drying at a constant temperature, weighing, and determining the small intestinal degradation rate.

The utility model provides a degradable anastomotic clip and a release structure, comprising a main body and a clamping jaw, wherein the main body is made of elastic material and is provided with two opposite mounting seats that can be opened and closed elastically. The clamping jaws are installed in pairs at the two mounting seats of the main body, and the two clamping jaws have opposite teeth, and are elastically opened and closed through the mounting seats. The entire clamping jaw or the teeth are made of degradable material and a coating that can resist digestion by digestive fluid for a certain period of time. The anastomotic clip provided by the utility model is as simple to operate as the existing anastomotic clip. At the same time, since the material used to make the clamping jaws of the utility model is biodegradable, after a suitable period of time, it can be degraded under the digestive action of the gastrointestinal digestive fluid and the absorption action of the tissue, and automatically detached from the tissue, so that the anastomotic clip can be automatically detached after a specific period of time. In addition, since the teeth of the clamping jaws are degraded, the situation where the anastomotic clip scratches the user's stomach when moving in the stomach and intestines can also be reduced.

The present invention relates to the technical field of medical devices, and discloses a gastrointestinal anastomotic fistula recovery and closure component, comprising: a drainage tube, an outer ring of the drainage tube is spirally wound with an adsorption sponge, the adsorption sponge comprises a dense section and a loose section, the outer edge of the dense section is in contact with the intestinal wall at the anastomotic fistula, the drainage tube is provided with adsorption holes that cooperate with the dense section, and the drainage tube is connected to a negative pressure drainage part. By using the gastrointestinal anastomotic fistula recovery and closure component described in the present invention, adsorption ports can be opened at corresponding positions of the drainage tube according to the number, length, and specific location distribution of the anastomotic fistulas, and an adsorption sponge can be spirally wound around the outer ring of the drainage tube, forming a dense section in the area near the adsorption holes and a loose section in the area between two adjacent groups of adsorption holes. After the drainage tube is placed in the intestine, multiple dense sections fill the corresponding anastomotic fistulas and the surrounding part of the intestine, and can continuously absorb secretions and digestive fluids at multiple gastrointestinal anastomotic fistulas.

The application discloses a camel special rumen internal environment monitoring device, which comprises an insertion collection component, a suction component is fixedly connected to one end of the insertion collection component, and the insertion collection component is used for inserting into a camel rumen to collect rumen fluid; a bite prevention component is fixedly arranged on the insertion collection component; and a sealing adjustment component is arranged. In the prior art, a common rumen internal environment monitoring device is contacted with an esophagus during insertion into a rumen, part of esophageal fluid or food residues enter the monitoring device, and monitoring errors are caused. By arranging the sealing adjustment component, automatic sealing protection can be realized during insertion, the sealing adjustment component can be adjusted to be opened after complete insertion into the rumen, rumen fluid can be collected and detected, and the phenomenon that other foreign matters are introduced due to contact with the esophagus during insertion is effectively avoided.

The invention relates to a bionic gastrointestinal digestive system in a lunar environment, and belongs to the technical field of bionic digestive systems. The bionic stomach digestion system, the bionic small intestine digestion system and the bionic colon fermentation system which are suspended in the water tank are arranged and are circularly connected to form the bionic gastrointestinal digestion system in the simulated moon environment; according to the astronaut gastrointestinal tract digestion simulation device, the stomach metabolism condition, the small intestine metabolism condition and the intestinal flora distribution and metabolism condition in the colon of an astronaut in a weightless environment can be simulated, the gastrointestinal tract digestion problem of the astronaut can be deeply studied, spaceflight food is developed, automation is achieved, and according to a preset program, the astronaut gastrointestinal tract digestion problem can be effectively solved. The PLC controls the addition of a sample, digestive juice and a buffer solution, and simulates the wriggling and emptying of a gastric digestive system, so that the operation is more convenient.

Provided is an isolated culture method for primary umbilical cord mesenchymal stem cells. The method comprises the following steps: S1, pretreating umbilical cord tissue; S2, adding the pretreated umbilical cord tissue to a digestive fluid containing type II collagenase, and performing digestion via shaking to obtain a digested mixed solution; S3, diluting the digested mixed solution with normal saline, performing centrifugation to collect crude precipitates, re-suspending same with normal saline, and performing centrifugation and washing to obtain precipitates; S4, transferring the precipitates into a culture solution, and performing suspension culture in a carbon dioxide incubator; and S5, transferring cells which have been subjected to the suspension culture to a sterile centrifuge tube, pipetting and mixing uniformly, performing centrifugation and washing to collect cell precipitates, and performing adherent culture on the cell precipitates to obtain primary umbilical cord mesenchymal stem cells. By means of the method, highly viable and highly proliferative primary UCMSCs can be obtained within 4–8 days from a serum-free and serum-substitute-free culture solution with clear components, thereby establishing a foundation for downstream development of new drugs and clinical research.

The present invention relates to the technical field of preparing the antibiotic tylvalosin, and provides a high-bioavailability tylvalosin dry suspension and preparation method. The preparation method comprises 5-20 parts of tylvalosin tartrate, 10-40 parts of a suspending agent, 5-20 parts of a surfactant, 10-20 parts of a carrier dispersing material, and an appropriate amount of purified water. The preparation method comprises the following steps: uniformly dispersing the formulated suspending agent with an appropriate amount of purified water, adjusting the pH to acidic with hydrochloric acid, adding a surfactant dissolved in 95% ethanol, then dissolving the drug in hydrochloric acid at pH 2.0 and adding the surfactant to the suspension, grinding the suspension in a wet nano-grinder to obtain a drug-loaded nanosuspension, adding a carrier dispersing material, and spray drying. The drug of the present invention is suspended in water for a long time at the nanoscale, releasing little drug in simulated gastric fluid but slowly in simulated intestinal fluid, thereby extending the drug's duration of action in the intestine. The surfactant increases the drug's solubility and permeability.