Teeth whitening compositions and methods

Inactive Publication Date: 2010-10-21
KLOX TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]Another advantage of the present invention is that the compositions can be effective when applied only for a short period of time (e.g., 1 minute in some embodiments). Accordingly, sensitivity due to, e.g., percolation of hydrogen peroxide to the pulp tissue causing (e.g., pulpal inflammation), may be minimized or eliminated. Another advantage of the present invention is that the compositions do not require compounds that generate heat, and therefore, discomfort associated with compositions that generate heat may be minimized or eliminated. Yet another advantage is that dyes can be used (e.g., Eosin) that are less toxic than dyes such as Rhodamine B.
[0009]In one aspect, the present invention features a tooth whitening comp

Problems solved by technology

Tooth sensitivity following treatment, and the time required for teeth whitening compositions (typically r

Method used

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  • Teeth whitening compositions and methods
  • Teeth whitening compositions and methods

Examples

Experimental program
Comparison scheme
Effect test

Example

Example 1

Preparation of an Exemplary Whitening Composition and Activation by Actinic Light

[0076]A premix was prepared by mixing 4 mg of Eosin B, 1 mg Erythrosine B, 450 mg fumed silica, and 45 mg sodium perborate. Separately, the pH of a 50% hydrogen peroxide solution was adjusted to pH 6 using sodium acetate solution. Approximately 4-6 ml of the adjusted hydrogen peroxide solution was then added to the premix in a plastic mixing chamber and immediately applied.

[0077]The gel was applied to frontal surface of the teeth of each subject beginning from the frontal anterior incisors, followed by the posteriors, and finally the posterior incisors. The gel was activated by a KTP laser set at a continuous wave of 0.5 watts. The laser was applied to each tooth for 2-3 seconds. During this time, the gel turned from orange-red to transparent and eventually became dull. After 3-4 minutes for two full arches from premolar to premolar, the gel was aspirated, and the teeth were lightly scrubbed wi...

Example

Whitening Effect of Composition

[0078]A comparative study was conducted on 10 volunteers between an exemplary composition of the present invention and the SMARTBLEACH laser teeth whitening systems, which is a composition comprising Rhodamine B and hydrogen peroxide. The shade of each patient's teeth was recorded prior to application of whitening composition.

[0079]Teeth were coated with the composition prepared in Example 1 and exposed to actinic light from a green laser set at 532 nm for one minute for the entire mouth (4-5 seconds per tooth) and then the composition was removed. The comparative composition was applied to the teeth and exposed to light from a green laser set at 532 nm for 30 seconds per tooth and then left on the surface of the tooth for 10 minutes, in accordance with the manufacturer instructions provided with the composition. The comparative composition required at least 3 to 4 applications, for a total duration of about 1.5 hours for the entire mouth. The composit...

Example

Example 3

Effect of Actinic Light Source

[0083]A study was conducted on 28 volunteers comparing the effect of different actinic light sources in whitening with the composition of Example 1. A prophylactic session was performed on each patient 3-4 days before the bleaching session. The shade of each patient's teeth was recorded prior to application of whitening composition.

[0084]Teeth were coated with the composition prepared in Example 1 and exposed to different sources of actinic light: a green laser (KTP) at 532 nm, a blue (argon) laser at 480-414 nm, a photo curing halogen lamp, and a LED photocuring device. The activation was performed in the different patients for the left or the right sides of their dental arches according to an activation randomization mode. Specifically, a first patient's right side was activated with the 532 nm green laser, while the left side was activated with the 480 nm-514 nm blue-green laser. A second patient's right side was activated with the photocuri...

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Abstract

Disclosed herein are teeth whitening compositions generally including an oxidizing agent (e.g., a peroxide), and an activating agent that has an emission wavelength between about 400 nm and about 570 nm (e.g., Eosin B, Eosin Y, or Erythrosine B). Methods of employing these compositions to whiten teeth, methods of making these compositions and kits that include some or part of the composition ingredients, are also described.

Description

CROSS-REFERENCE TO RELATED APPLICATION[0001]This application is a continuation-in-part of U.S. patent application Ser. No. 11 / 598,206 filed on Nov. 9, 2006 and hereby incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates generally to teeth whitening compositions. More specifically, the invention relates to teeth whitening compositions and kits that can be employed to provide a desired whitening effect (e.g., at least two shades of whitening) in less than about 5 minutes of total exposure to actinic light without significant post-treatment sensitivity.BACKGROUND OF THE INVENTION[0003]Peroxide and peroxyacid compounds, such as hydrogen peroxide and carbamide peroxide, have been disclosed as useful in teeth whitening compositions. Application of UV or visible light from, e.g., Argon lasers, has been employed to accelerate whitening after application of peroxide compositions to the teeth. Additionally, whitening compositions have been described that include...

Claims

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Application Information

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IPC IPC(8): A61C19/06A61K8/02A61K8/22A61Q11/00
CPCA61K8/22A61K8/36A61K8/498A61N5/062A61K2800/592A61Q11/00A61K6/0061A61K2800/434A61K6/66A61K8/19A61K8/732A61K8/81A61K2800/43
Inventor PIERGALLINI, REMIGIOLOUPIS, NIKOLAOS
Owner KLOX TECH
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