Aquatic product fish skin gelatin sponge and preparation method thereof

A technology of fish skin gelatin and aquatic products, which is applied in the field of medical devices, can solve the problems of fast degradation and poor flexibility, and achieve the effects of simple preparation process, strong mechanical strength, easy storage and use, and economical effect

Inactive Publication Date: 2014-01-22
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as a biomedical material, aquatic collagen has the same disadvantages as terrestrial mammalian collagen, such as fast degradation in vivo and poor flexibility, which limit its application.

Method used

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  • Aquatic product fish skin gelatin sponge and preparation method thereof
  • Aquatic product fish skin gelatin sponge and preparation method thereof
  • Aquatic product fish skin gelatin sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 aquatic fish skin gelatin sponge

[0034] 1.1 Preparation of aquatic fish skin gelatin sponge with different concentrations:

[0035] Weigh 75mg, 150mg, 225mg, 300mg, 375mg and 450mg of tilapia skin aquatic gelatin obtained by spray drying, add them to 0.05mol / L acetic acid solution respectively, and set the volume to 15mL, and the established gelatin concentration is 5mg / mL respectively , 10mg / mL, 15mg / mL, 20mg / mL, 25mg / mL and 30mg / mL gelatin acetic acid solution, after proper swelling at room temperature, put it in a 50°C water bath to aid dissolution, and take it out every 10min and put it on the stirrer Stir for 5 minutes until the gelatin is completely dissolved in the acetic acid solution and the liquid becomes transparent and uniform. After vacuum degassing for 20 minutes, pour the gelatin solution into a 7.5cm×1.5cm (diameter×height) petri dish, seal with plastic wrap, cross-link overnight at 4°C, pre-cool at -20°C for 8 hours, and...

Embodiment 2

[0051] Determination of properties of aquatic fish skin gelatin sponge:

[0052] Select each gelatin sponge product that the above-mentioned embodiment that apparent shape is better obtains and carry out scanning electron microscope detection, observe the thickness of its fiber, the size of aperture, the uniformity of aperture etc. (referring to Figure 7-18 ).

[0053] It can be seen from the scanning electron microscope picture that at 100 times magnification:

[0054] 1. The sponge made of tilapia skin gelatin alone has larger pores, thinner fibers and uneven gaps;

[0055] 2. The sponge made of tilapia skin gelatin and glutaraldehyde has smaller voids, thicker fibers and uniform voids;

[0056] 3. The sponge made of tilapia skin gelatin and chitosan (9:1 and 8:2) has smaller voids, thicker fibers, and uniform voids, and the sponge made of 8:2 is more than the sponge made of 9:1 The sponge gap is more uniform;

[0057] 4. The sponge made of tilapia skin gelatin, chitosa...

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Abstract

The invention relates to the technical field of medical instruments, and in particular relates to an aquatic product fish skin gelatin sponge and a preparation method thereof. The aquatic product fish skin gelatin is used as a main material, chitosan is used as an auxiliary material, and glutaraldehyde is used as a cross-linking agent; the raw material liquids of different proportions are subjected to freeze drying to prepare fish skin gelatin sponges with different properties; the preparation process of the sponge is simple; the sponge is low in cost and readily available; some defects of the conventional collagen sponge are overcome. The prepared fish skin gelatin sponge has a uniform porous netlike microstructure and higher mechanical strength and good moisture absorption and is a better biomedical material.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an aquatic fish skin gelatin sponge and a preparation method thereof. Background technique [0002] Collagen is the most abundant and widely distributed protein in animals. Collagen has the characteristics of unique triple helix structure, low antigenicity, non-toxicity, good biocompatibility and biodegradability, and has been widely used in tissue engineering scaffold materials, hemostatic sponges, drug controlled release systems, gene Delivery carrier, cosmetic surgery and other biomedical fields. At present, the collagen used in China mainly comes from the skin and Achilles tendon of pigs and cattle, but with the occurrence of diseases such as mad cow disease and foot-and-mouth disease, people have questioned their safety; The application of collagen has been limited in some areas. Therefore, there is an urgent need to seek collagen sources with better quality and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08L5/08C08J3/24C08H1/06
Inventor 史文军闫鸣艳秦松张朝晖崔红利
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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