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Gelatin sponge embolism microspheres and preparation method thereof

A technology of gelatin sponge and embolizing microspheres, applied in the field of interventional medicine, can solve the problems of high cost, blockage of embolization catheters, complicated processes, etc., and achieves the effects of less environmental pollution, short production cycle and simple operation.

Pending Publication Date: 2018-02-02
HAINAN JIANKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method is cumbersome, and the shape of the prepared gelatin sponge particles is irregular, it is difficult to accurately classify and mark its particle size, and it is easy to cause clogging of the embolism catheter, reflux, etc.
[0006] Chinese Patent Authorization Publication No. CN 102585258B discloses a preparation method of gelatin embolization microspheres, which uses acetone to repeatedly wash the residual oil phase on the surface of the microspheres during the preparation process, which is costly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of gelatin sponge embolization microspheres, comprising the following steps:

[0025] (1) Preparation of gelatin aqueous solution: Take 250g of gelatin, add purified water to 1000g, heat and stir in a water bath at 55°C to dissolve.

[0026] (2) Slowly add the gelatin aqueous solution into the liquid paraffin containing 1% Span 80 (gelatin solution: liquid paraffin = 1:2), stir at 150 rpm for 5 minutes;

[0027] (3) Add 50ml of 40% formaldehyde solution, and continue to stir and react at 6°C for 2 hours;

[0028] (4) Stand for 10 minutes, pour off the oil layer after the layers are separated, wash the microspheres several times with 20% Tween 80 aqueous solution until the liquid paraffin is cleaned, and then wash several times with purified water;

[0029] (5) Sieve and sieve, and dry microspheres with different particle sizes at low temperature (not exceeding 60° C.), to obtain gelatin sponge microspheres.

Embodiment 2

[0031] A preparation method of gelatin sponge embolization microspheres, comprising the following steps:

[0032] (1) Preparation of gelatin aqueous solution: Take 200g of gelatin, add purified water to 1000g, heat and stir in a water bath at 60°C to dissolve.

[0033] (2) Slowly add the gelatin aqueous solution into the liquid paraffin containing 1% Span 80 (gelatin solution: liquid paraffin = 1:3), stir at 250 rpm for 3 minutes;

[0034] (3) Add 50ml of 40% formaldehyde solution, and continue to stir and react at 0°C for 3 hours;

[0035] (4) Stand still for 15 minutes, pour off the oil layer after the layers are separated, wash the microspheres several times with 20% Tween 80 aqueous solution until the liquid paraffin is cleaned, and then wash several times with purified water;

[0036] (5) Sieve and sieve, and dry microspheres with different particle sizes at low temperature (not exceeding 60° C.), to obtain gelatin sponge microspheres.

Embodiment 3

[0038] A preparation method of gelatin sponge embolization microspheres, comprising the following steps:

[0039] (1) Preparation of gelatin aqueous solution: Take 300g of gelatin, add purified water to 1000g, heat and stir in a water bath at 60°C to dissolve.

[0040] (2) Slowly add the gelatin aqueous solution into the liquid paraffin containing 1% Span 80 (gelatin solution: liquid paraffin = 1:1.5), stir at 250 rpm for 3 minutes;

[0041] (3) Add 50ml of 40% formaldehyde solution, and continue to stir and react at 10°C for 1.5 hours;

[0042] (4) Stand still for 8 minutes, pour off the oil layer after layering, wash the microspheres several times with 20% Tween 80 aqueous solution until the liquid paraffin is cleaned, and then wash several times with purified water;

[0043] (5) Sieve and sieve, and dry microspheres with different particle sizes at low temperature (not exceeding 60° C.), to obtain gelatin sponge microspheres.

[0044] The gelatin sponge embolization micro...

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Abstract

The invention discloses a method for preparing gelatin sponge embolism microspheres, and the method comprises the following steps: (1) preparing a gelatin aqueous solution; (2) slowly adding the gelatin aqueous solution to an oil phase containing an emulsifier, and stirring evenly; (3) adding a cross-linking agent, reacting while stirring at 0-10 DEG C; (4) standing, pouring an oil layer out afterlayering, using a Twain 80 aqueous solution for washing microspheres until the oil phase is washed away, and using purified water to wash for a plurality of times; and (5) sieving for screening, andrespectively drying the microspheres with different particle sizes at low temperature to obtain the gelatin sponge embolism microspheres. The preparation method is simple in operation, the productioncycle is short, the cost is low, the hemolysis test meets standard requirements, and the residual amount of the cross-linking agent conforms to clinical use standards.

Description

technical field [0001] The invention relates to the technical field of interventional medicine, in particular to a gelatin sponge embolization microsphere and a preparation method thereof. Background technique [0002] Interventional vascular embolization refers to the interventional therapy technique of embolizing local blood vessels through a catheter under image monitoring. It is mainly used for hemostasis of hemorrhage, hemangioma, vascular malformation, benign and malignant tumors, and the inactivation of some organ functions. [0003] Modern interventional vascular embolization was developed in the 1950s. With the development of imaging equipment and material science, interventional vascular embolization has been greatly developed in depth and breadth. An important factor in the development of interventional vascular embolization technology benefits from the research and application of embolic materials. At present, there are many kinds of embolic materials, which can ...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/00
CPCA61L24/001A61L24/0036A61L24/104A61L2300/252A61L2300/418
Inventor 杨顶建吴垚彭昌华
Owner HAINAN JIANKE PHARMA
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