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A technique for preparing absorbable gelatin sponge particle suppository with glutin as raw material

A technology of gelatin sponge and embolic agent, which is applied in the field of interventional medicine, can solve the problems that the residual amount of formaldehyde is difficult to reach the clinical standard, and the raw materials are expensive, and achieve the effect of low cost and broad application prospects

Inactive Publication Date: 2008-04-16
郑隆泗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw materials in the preparation process disclosed in this patent are relatively expensive, and the residual amount of formaldehyde is difficult to reach the clinical standard

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Take 28g of 250ps gelatin raw material, put it in a 500ml beaker, add 350ml of water for injection, stir for 1min, then let it stand for swelling for 1h, until the gelatin particles are transparent;

[0028] (2) Under the condition of a water bath at 20°C, the above-mentioned gelatin solution was stirred and dissolved until the solution was transparent;

[0029] (3) Transfer the dissolved transparent gelatin solution to a 2000ml beaker, heat it in a water bath at 20°C, stir with an electric mixer, and add a concentration of 1% formaldehyde solution while stirring under the condition of low-speed stirring 60ml, cover with plastic paper, when foam appears, increase the speed of the mixer to a high speed (2000 rpm), stir for 15min, and stop stirring when the gelatin solution is uniform and delicate foam (volume is about 1600ml), and The solution was quickly transferred to the freezer, the freezing time was 5 hours, and the freezing temperature was -50°C until it became...

Embodiment 2

[0041] (1) Take 28g of 250ps gelatin raw material, put it in a 500ml beaker, add 350ml of water for injection, stir for 1min, then let it stand for swelling for 1h, until the gelatin particles are transparent;

[0042] (2) Under the condition of a water bath at 50°C, the above-mentioned gelatin solution was stirred and dissolved until the solution was transparent;

[0043] (3) Transfer the dissolved transparent gelatin solution to a 2000ml beaker, heat it in a water bath at 50°C, stir with an electric mixer, and add a concentration of 15% formaldehyde solution while stirring under the condition of low-speed stirring 30ml, cover with plastic paper, when foam appears, increase the speed of the mixer to a high speed (2000 rpm), stir for 15min, and stop stirring when the gelatin solution is uniform and delicate foam (volume is about 1600ml), and The solution was quickly transferred to the freezer, the freezing time was 50 h, and the freezing temperature was -5°C until it became wh...

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Abstract

The present invention provides a technique for preparing the gelfoam particle suppository which uses the glutin as the raw material, and the invention comprises the steps of: dissolving the glutin to the water, stirring to uniform at the water-bath condition when the formaldehyde solution is added, and the white porous spongy product is produced after freezing; defreezing the white porous spongy product, removing the water and formaldehyde after washing, and the gelfoam is obtained; crushing the gelfoam after freezing and the gelfoam particle is obtained; defreezing the gelfoam particle and placing the gelfoam particle to the water to do sifting after dewatering, and drying after sifting; disinfecting the dried gelfoam particle after sifting and the gelfoam particle suppository is obtained. The cost of the method in the invention is low and the invention easily causes that the residual quantity of the formaldehyde reaches the clinical using standard.

Description

technical field [0001] The invention relates to the field of interventional medicine, in particular to a process for preparing a gelatin sponge particle embolism using gelatin as a raw material Background technique [0002] Interventional medicine is the third clinical medical discipline developed in the past two decades, keeping pace with internal medicine and surgery. With the development of modern medical imaging technology, the scope of interventional therapy is getting wider and wider. Interventional medicine uses various flexible and clear imaging technologies and increasingly powerful computer post-processing technologies to analyze lesions in an all-round way, conduct targeted and guided treatments, and cut out pain accurately and efficiently without surgery. Interventional medicine has developed to this day, and has differentiated into specialized interventional disciplines such as tumor intervention, neurological intervention, cardiac catheterization, vascular sur...

Claims

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Application Information

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IPC IPC(8): A61L31/04
Inventor 郑隆泗
Owner 郑隆泗
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