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Biodegradable quick hemostyptic dressing, and its preparing method

A hemostatic dressing and biodegradable technology are applied in the field of rapid hemostatic dressing and its preparation, which can solve the problems of limited application of hemostatic dressing, no anti-edema effect, weak hemostatic ability, etc., achieve good anti-edema performance, eliminate hidden dangers of viruses, and promote recovery effect of ability

Inactive Publication Date: 2007-07-25
SANSEN BIOTECH XIAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Simple gelatin sponge or collagen hemostatic sponge have poor toughness and no anti-edema effect, such as patents CN 1569244A and CN 1385143A; simple hyaluronic acid dressings have weak hemostatic ability
International research on biodegradable hemostatic dressings is also mainly focused on collagen and its modification, such as patents US6649162, AU 726163B and RU 2122867, but they all use traditional animal-derived collagen, which inevitably exists Virus hidden dangers greatly limit the application of the hemostatic dressing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The human-like collagen was dissolved in distilled water into a solution with a mass percentage of 0.5%; the hyaluronic acid with a molecular weight of 1 million Daltons was dissolved in distilled water into a solution with a mass percentage of 2.0%; then the two solutions were mixed in a mass ratio of 20 : 1 mix evenly, and add the glycerol that mass percent is 0.0008% in the mixed solution, pack in the container; After vacuum defoaming, freeze-dry to become the thick sponge of 2mm; Cobalt 60 Can be sterilized after irradiation.

Embodiment 2

[0028] The human-like collagen was dissolved in distilled water into a solution with a mass percentage of 0.5%; the hyaluronic acid with a molecular weight of 1 million Daltons was dissolved in distilled water into a solution with a mass percentage of 2.0%; then the two solutions were mixed in a mass ratio of 20 : 1 mix evenly, and add the glycerol that mass percentage is 0.0001% to the mixed solution, pack in the container; Air-dry at room temperature and form the thick film of 0.2mm; Cobalt 60 Can be sterilized after irradiation.

Embodiment 3

[0030] The human-like collagen was dissolved in distilled water into a solution with a mass percentage of 0.5%; the hyaluronic acid with a molecular weight of 2 million Daltons was dissolved in distilled water into a solution with a mass percentage of 1.0%; and then the two solutions were mixed in a mass ratio of 20 : 1 mixed evenly, and adding mass percent to the mixed solution is 0.0003% glycerol and 0.0003% thrombin, subpackaged in containers; freeze-dried into 2mm thick sponge after vacuum defoaming; cobalt 60 Can be sterilized after irradiation.

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PUM

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Abstract

A biodegradable dressing for fast haemostasis is prepared from collagen and hyaluronic acid. It has high resistance to edema, high power to recover the damaged tissue, and high safety.

Description

Technical field: [0001] The invention relates to a biodegradable rapid hemostatic dressing and a preparation method thereof, belonging to the field of biomedical materials. Background technique: [0002] Extensive bleeding and oozing during surgery and trauma are difficult problems that need to be addressed. Collagen is the protein with the most content and widest distribution in animals. It is the main structural protein of the body and the main component of supporting tissue and connective tissue. It has good biocompatibility, hemostatic performance, and the function of promoting new cell formation and Cell Adhesion. Studies in recent years have shown that collagen can quickly stop bleeding within 10 seconds, promote granulation growth and wound healing, and prevent re-bleeding. [0003] Human-like collagen is obtained by reverse-transcribing a section of mRNA of collagen known in the human body to generate cDNA, then repeating and modifying specific sequences, transform...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/28
Inventor 马晓轩朱晓丽
Owner SANSEN BIOTECH XIAN
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