33results about How to "Prevent rebleeding" patented technology

The invention discloses a hemostat and a preparation method thereof. A finished product liquor per 1000 g comprises 10-16 g of termite fungus garden composition powder, 4-6 g of collagen, 0.02-0.04 g of ternary acid, 7-9 g of bactericidal agent and the balance of water. The invention has the advantages that the termite fungus garden composition powder containing rich nutrient contents is utilizedin the prescription, the functions of detumescence, convergence and hemostasis are achieved, meanwhile the weak body is tonified without any side effect; the collagen has very strong affinity with different cells, and also has ideal affinity with growth factors which play a key role in the process of wound healing, after blood coagulation, the collagen can also prevent bleeding again through stimulating the regeneration and the repair of tissues. The hemostat is not fastidious about the using object, has fast hemostasis effect, excellent functions of anti-inflammatory, detumescence and acesodyne without toxic or side effect, or untoward reaction of stimulations. The preparation method has less technical steps and non-rigorous preparation condition, and can be suitable for the industrial mass production.

The invention relates to omeprazole sodium and a preparation method, and in particular relates to a method for preparing omeprazole or a salt thereof. The method comprises the following steps of: (1) reacting 2-chlorinated methyl-3,5-dimethyl-4-methoxypyridine or a salt thereof and 2-mercapto-5-methoxy-1H-benzimidazole to generate 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2-yl)methylmercapto]-1H-benzimidazole; and (2) oxidizing 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2-yl)methylmercapto]-1H-benzimidazole to generate omeprazole. The invention further relates to omeprazole prepared by the invention or a sodium salt thereof. A product prepared by the method has high purity.

The invention discloses a composition for treating lumbago and a preparation method of the composition, and aims at providing a traditional Chinese medicine composition which is capable of activating blood, dredging collaterals, relieving swelling and pain and effectively treating lumbago, and is small in side effect. According to the technical main points, the composition is prepared from the following components in parts by weight: 50-100 parts of rose mallow root whole plants, 50-100 parts of mirabilis jalapa whole plants, 30-100 parts of impatiens balsamina whole plants, 100-150 parts of paederia scandens whole plants, 30-100 parts of sansevieria trifasciata leaf whole plants and 10-30 parts of ginger. The composition belongs to the technical field of the traditional Chinese medicine.

The present invention discloses a kind of biodegradable hemostatic sponge material and its preparation process. The preparation process includes the following steps: 1. dissolving collagen like human collagen in distilled water to form 0.5-3 % concentration solution; 2. dissolving chitosan in dilute acid solution to form 0.5-2 % concentration solution and neutralizing with alkali; and 3. mixing the two kinds of obtained solution, vacuum defoaming and freeze drying to form sponge and Co-60 irradiating sterilization. The biodegradable hemostatic sponge material has high adhesion to tissue, less immune rejection, high toughness, excellent pain relieving and sterilizing effect, capability of promoting the recovery of damaged tissue, high hemostatic effect and greatly raised safety.

The present invention discloses a preparation method of an antiphlogistic and antisticking stanching sponge. The preparation method includes the following steps: through the cross linking of polyvinyl alcohol, chitosan gel microspheres are fixed on the inner wall of a sponge, the sponge is then soaked in antiphlogistic solution and antisticking solution, and finally, the PVA / drug-loaded chitosan antiphlogistic and antisticking stanching sponge is prepared. The antiphlogistic and antisticking stanching sponge prepared by the method can be trimmed according to the size of an operative cavity inorder to be placed into the corresponding part, the pressure on the circumference is uniform, blood can be thoroughly stanched, and the injury on the mucous membrane of the operative cavity is little. The antiphlogistic and antisticking stanching sponge prepared by the method, which has good antiphlogistic, stanching and antisticking functions, biocompatibility, and mechanical and anti-oedema properties, can promote the injured tissues to have strong recovering capability, prevent rebleeding and avoid the inevitable potential virus hazard caused by glutin and animal collagen proteins, so the use safety is greatly improved, and moreover, the antiphlogistic and antisticking stanching sponge can alleviate the pain and discomfort suffered by patients. The antiphlogistic and antisticking stanching sponge is expected to substitute the import products and have remarkable social and economic benefits.

The invention relates to a calcium ion exchange porous starch hemostatic material and its preparation method and application. The calcium ion exchange porous starch hemostatic material of the present invention is prepared from starch through gelatinization, emulsification, pore formation, crosslinking and calcium ion exchange, and its raw materials include: starch, oil phase, porogen, emulsifier, calcium chloride, crosslinking agent and the remainder of water. The hemostatic material is made porous by ethanol alkali method to increase its specific surface area, cross-linked to increase its structural stability, reversed-phase microemulsion technology to control its particle size distribution, and the surface is modified with calcium ions to enhance its hemostatic performance , biodegradability and biocompatibility. The calcium ion-exchanged porous starch hemostatic material provided by the present invention has rich sources of main raw materials, good safety, and no residue, and can be widely used in the hemostasis application of substantive organs in the body and irregular bleeding such as diffuse bleeding, and does not require debridement after hemostasis , the hemostatic effect can continue to the postoperative period, and it can be degraded and absorbed in the human body after the postoperative period.

The invention relates to pantoprazole sodium and a preparation method thereof, in particular to a method of preparing pantoprazole sodium. The method comprises the steps of 1) using 2-hydroxymethyl-3,4-dimethoxypyridine (II) as a start material to generate a compound of formula III under the action of a chloride; 2) subjecting the compound of formula III and 5-difluoromethoxy-2-thiol-1H-benzimidazole to condensation in the presence of an inorganic base so as to generate a compound of formula IV; 3) using an oxidant to oxidize the compound of formula IV to generate 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl-1H-benzimidazole, namely, pantoprazole; 4) allowing the obtained 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl-1H-benzimidazole to react with sodium hydroxide to generate a salt, namely, pantoprazole sodium (I); and optionally 5) refining the pantoprazole sodium. The product prepared via the method has high purity; related impurities, such as oxidation impurity, reduction impurity, decomposition impurity, have low contents.

The invention belongs to the field of medicines, and particularly relates to a gel preparation for treating functional uterine bleeding and application thereof. The gel preparation comprises the following active components of alvimopan or composition of alvimopan and ectoin, wherein the ratio of alvimopan to ectoin in parts by weight is 1:(3 to 5). The gel preparation has the advantages that the function of shortening the bleeding time of the functional uterine bleeding is realized by external administration or local vagina administration; when the alvimopan or the ectoin is singly used, the effect can be realized; when the alvimopan and the ectoin are jointly used, the effect is further improved.

The invention discloses an absorbable and degradable multipurpose biocompatible material. The raw materials of the absorbable and degradable multipurpose biocompatible material comprise chitosan, collagen and hyaluronic acid or sodium alginate in a weight ratio of (2 to 8): (0.5 to 3): (1 to 5); adding a dehydrating agent; generating hydrogel by a cross-linking reaction; and finally performing freeze-drying to prepare sponge or film. The absorbable and degradable multipurpose biocompatible material disclosed by the invention can be used as a bleeding-stopping anti-adhesion material, good in tissue adhesion, remarkable in anti-adhesion effect, capable of rapidly stopping bleeding, preventing adhesion, promoting tissue healing, preventing rebleeding, eliminating the inevitable virus hidden troubles of gelatine and animal collagen, and greatly improving safety, complete in degradation, capable of being absorbed and utilized by the body, and free of side effects on the body. The absorbable and degradable multipurpose biocompatible material can also be used as a scaffold for tissue engineering, artificial skin and the like, and good in biocompatibility, absorbability and degradability.

The invention discloses a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, which is prepared from the following bulk drugs: leech, lumbricus, scorpio and pseudo-ginseng. The traditional Chinese medicine composition disclosed by the invention accords with the theories of traditional Chinese medicine pharmacology of removing stasis, promoting new and self-quenching wind through blood circulation; in addition, by utilizing the traditional Chinese medicine composition formula, the traditional Chinese medicine composition disclosed by the invention is capable of promoting circulation, removing stasis, removing blood stasis, clearing hematoma, stopping rehaemorrhagia, reducing intracranial pressure, eliminating encephaledema, adjusting whole-body blood, resisting stress reaction and improving microcirculation and has the unique curative effects to perennial serious hypertension, cerebral hemorrhage, stroke, coronary heart disease and cerebral thrombosis.