33results about How to "Prevent rebleeding" patented technology

The invention relates to omeprazole sodium and a preparation method, and in particular relates to a method for preparing omeprazole or a salt thereof. The method comprises the following steps of: (1) reacting 2-chlorinated methyl-3,5-dimethyl-4-methoxypyridine or a salt thereof and 2-mercapto-5-methoxy-1H-benzimidazole to generate 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2-yl)methylmercapto]-1H-benzimidazole; and (2) oxidizing 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2-yl)methylmercapto]-1H-benzimidazole to generate omeprazole. The invention further relates to omeprazole prepared by the invention or a sodium salt thereof. A product prepared by the method has high purity.

The invention discloses a hemostat and a preparation method thereof. A finished product liquor per 1000 g comprises 10-16 g of termite fungus garden composition powder, 4-6 g of collagen, 0.02-0.04 g of ternary acid, 7-9 g of bactericidal agent and the balance of water. The invention has the advantages that the termite fungus garden composition powder containing rich nutrient contents is utilizedin the prescription, the functions of detumescence, convergence and hemostasis are achieved, meanwhile the weak body is tonified without any side effect; the collagen has very strong affinity with different cells, and also has ideal affinity with growth factors which play a key role in the process of wound healing, after blood coagulation, the collagen can also prevent bleeding again through stimulating the regeneration and the repair of tissues. The hemostat is not fastidious about the using object, has fast hemostasis effect, excellent functions of anti-inflammatory, detumescence and acesodyne without toxic or side effect, or untoward reaction of stimulations. The preparation method has less technical steps and non-rigorous preparation condition, and can be suitable for the industrial mass production.

The invention relates to pantoprazole sodium freeze-dried powder injection, in particular to freeze-dried powder injection which contains pantoprazole sodium, mannitol, citric acid and optional pH regulator. The invention further relates to a method for preparing the pantoprazole sodium freeze-dried powder injection disclosed by the invention. The pantoprazole sodium freeze-dried powder injection disclosed by the invention can be used for treating stomach diseases and has anticipated good properties.

The invention relates to an omeprazole sodium freeze drying powder injection pharmaceutical composition for injection. In particular, on the one hand, the invention relates to a freeze drying powder injection pharmaceutical composition which comprises omeprazole sodium, ethylenediamine tetraacetic acid disodium salt and an optional acidifying or alkalizing agent; on the other hand, the invention further relates to a method for preparing the omeprazole sodium freeze drying powder injection pharmaceutical composition for injection. The method is a conventional preparation method of the omeprazole sodium freeze drying powder injection pharmaceutical composition for injection. The omeprazole sodium freeze drying powder injection pharmaceutical composition for injection provided by the invention can be used for treating gastropathy and has an anticipated good property. For example, the omeprazole sodium freeze drying powder injection pharmaceutical composition for injection not only has excellent physical and chemical stabilities, but also has an excellent biological property.

The invention discloses a woundplast not sticking to a wound, which comprises a strip-shaped medical adhesive tape, an officinal cotton cushion soaked with antiphlogistic astringent is adhered on part of the medical adhesive tape and two plastic protective films covering the upper part of the officinal cotton cushion, wherein an antibacterial moisture conduction gauze woven from special-shaped section antibacterial fiber covers the officinal cotton cushion under the protective films; the length of the antibacterial moisture conduction gauze is shorter than that of the medical adhesive tape but longer than that of the officinal cotton cushion; and two ends of the antibacterial moisture conduction gauze are adhered on the medical adhesive tape. According to the invention, the special-shaped section antibacterial fiber is adopted to weave the antibacterial moisture conduction gauze, and the antibacterial moisture conduction gauze is used to cover the officinal cotton cushion with excellent hydroscopic property. When in use, the antibacterial moisture conduction gauze is in direct contact with the wound, the medicine component in the officinal cotton cushion acts on the wound through the antibacterial moisture conduction gauze, and the blood effluent from the wound is absorbed by the cotton cushion with high hydroscopic property through the gauze. When the blood solidifies, the used woundplast is easy to be separated from the wound due to less blood crusted on the wound surface, so that a second hurt to the wound is avoided.

The invention relates to omeprazole sodium and a preparation method, and in particular relates to a method for preparing omeprazole or a salt thereof. The method comprises the following steps of: (1) reacting 2-chlorinated methyl-3,5-dimethyl-4-methoxypyridine or a salt thereof and 2-mercapto-5-methoxy-1H-benzimidazole to generate 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2-yl)methylmercapto]-1H-benzimidazole; and (2) oxidizing 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridine-2-yl)methylmercapto]-1H-benzimidazole to generate omeprazole. The invention further relates to omeprazole prepared by the invention or a sodium salt thereof. A product prepared by the method has high purity.

The invention discloses a composition for treating lumbago and a preparation method of the composition, and aims at providing a traditional Chinese medicine composition which is capable of activating blood, dredging collaterals, relieving swelling and pain and effectively treating lumbago, and is small in side effect. According to the technical main points, the composition is prepared from the following components in parts by weight: 50-100 parts of rose mallow root whole plants, 50-100 parts of mirabilis jalapa whole plants, 30-100 parts of impatiens balsamina whole plants, 100-150 parts of paederia scandens whole plants, 30-100 parts of sansevieria trifasciata leaf whole plants and 10-30 parts of ginger. The composition belongs to the technical field of the traditional Chinese medicine.

The invention relates to the technical field of medical hemostatic patches, and particularly relates to a porcine-derived fibrin-electrostatic spinning nanofiber antibacterial hemostatic patch and a preparation method thereof. The preparation method comprises the following steps of: preparing a porcine-derived fibrinogen and thrombin blended suspension, then spraying or soaking the blended suspension on thes urface of a silk fibroin nanofiber film prepared by an electrostatic spinning technology, and drying to prepare the porcine-derived fibrin hemostatic absorbable patch for postoperative hemostasis. The patch has an excellent hemostatic effect, combines a fibrin thrombin hemostatic mechanism with the mechanical properties of the antibacterial silk fibroin film to enhance the hemostatic effect, and is natural and absorbable, so that the hemostatic effect is improved, and the fibrinogen and thrombin are combined into one, four components are changed into a single component, preparation is not needed, and the patch can be used immediately after being opened, thereby greatly simplifying the problems of complex use and long time consumption of the existing fibrinogen adhesive; and the patch can be stored and transported at room temperature, and has significant technical, cost and clinical advantages.

The present invention discloses a kind of biodegradable hemostatic sponge material and its preparation process. The preparation process includes the following steps: 1. dissolving collagen like human collagen in distilled water to form 0.5-3 % concentration solution; 2. dissolving chitosan in dilute acid solution to form 0.5-2 % concentration solution and neutralizing with alkali; and 3. mixing the two kinds of obtained solution, vacuum defoaming and freeze drying to form sponge and Co-60 irradiating sterilization. The biodegradable hemostatic sponge material has high adhesion to tissue, less immune rejection, high toughness, excellent pain relieving and sterilizing effect, capability of promoting the recovery of damaged tissue, high hemostatic effect and greatly raised safety.

The present invention discloses a preparation method of an antiphlogistic and antisticking stanching sponge. The preparation method includes the following steps: through the cross linking of polyvinyl alcohol, chitosan gel microspheres are fixed on the inner wall of a sponge, the sponge is then soaked in antiphlogistic solution and antisticking solution, and finally, the PVA / drug-loaded chitosan antiphlogistic and antisticking stanching sponge is prepared. The antiphlogistic and antisticking stanching sponge prepared by the method can be trimmed according to the size of an operative cavity inorder to be placed into the corresponding part, the pressure on the circumference is uniform, blood can be thoroughly stanched, and the injury on the mucous membrane of the operative cavity is little. The antiphlogistic and antisticking stanching sponge prepared by the method, which has good antiphlogistic, stanching and antisticking functions, biocompatibility, and mechanical and anti-oedema properties, can promote the injured tissues to have strong recovering capability, prevent rebleeding and avoid the inevitable potential virus hazard caused by glutin and animal collagen proteins, so the use safety is greatly improved, and moreover, the antiphlogistic and antisticking stanching sponge can alleviate the pain and discomfort suffered by patients. The antiphlogistic and antisticking stanching sponge is expected to substitute the import products and have remarkable social and economic benefits.

The invention discloses a traditional Chinese medicine composition for treating leukemia as well as a preparation method and a traditional Chinese medicine preparation thereof, and belongs to the field of anti-leukemia traditional Chinese medicines. The traditional Chinese medicine composition is prepared from 500-1500 parts of cornu bubali, 300-1200 parts of cornu cervi pantotrichum, 200-600 parts of hirudo, 150-400 parts of donkey-hide gelatin, 60-120 parts of centipede, 120-600 parts of American ginseng and 200-700 parts of ginseng. The preparation method of thetraditional Chinese medicinecomposition comprises the step of mixing cornu bubali powder and donkey-hide gelatin with fine powder of cornu cervi pantotrichum, hirudo, centipede, cornu bubali, American ginseng and ginseng to obtain the traditional Chinese medicine composition for treating leukemia. The traditional Chinese medicine composition disclosed by the invention has the effects of preventing bleeding, promoting a bloodregeneration function and improving the immune function, can effectively relieve symptoms of leukemia, and prolongs the lifetime of a patient. Compared with chemotherapy, the traditional Chinese medicine composition has the advantages of small side effects and low treatment cost; and clinical data shows that the total effective rate of the traditional Chinese medicine composition reaches 96.4% inleukemia treatment.

The invention discloses a method for culturing autologous hair-growing stromal stem cells for cerebral hemorrhage sequelae of a premature infant. The method comprises the following steps: 1) collecting bloody cerebrospinal fluid from a lateral ventricle of the cerebral hemorrhage premature infant; 2) centrifugally collecting cells; 3) resuspending the cells by using a neural stem cell culture medium and maintaining culture; 4) changing a half amount of the liquid in 3-5 days, digesting the cells after 6-8 days, and carrying out subculture; and 5) after passage to 3-5 generations, collecting the hair growth matrix stem cells. Through primary culture and subculture, the autologous neural stem cells of the child patient are massively amplified, then cryopreserved, recovered at a proper time and implanted into the brain of the child patient, so that the treatment effect on the cerebral hemorrhage sequelae of the premature infant can be greatly improved. The hair-growing stromal stem cells cultured by the culture method disclosed by the invention are large in amplification quantity and stable in property, and can meet the requirements of autotherapy of sick children.

The invention relates to a calcium ion exchange porous starch hemostatic material and its preparation method and application. The calcium ion exchange porous starch hemostatic material of the present invention is prepared from starch through gelatinization, emulsification, pore formation, crosslinking and calcium ion exchange, and its raw materials include: starch, oil phase, porogen, emulsifier, calcium chloride, crosslinking agent and the remainder of water. The hemostatic material is made porous by ethanol alkali method to increase its specific surface area, cross-linked to increase its structural stability, reversed-phase microemulsion technology to control its particle size distribution, and the surface is modified with calcium ions to enhance its hemostatic performance , biodegradability and biocompatibility. The calcium ion-exchanged porous starch hemostatic material provided by the present invention has rich sources of main raw materials, good safety, and no residue, and can be widely used in the hemostasis application of substantive organs in the body and irregular bleeding such as diffuse bleeding, and does not require debridement after hemostasis , the hemostatic effect can continue to the postoperative period, and it can be degraded and absorbed in the human body after the postoperative period.

The invention relates to pantoprazole sodium and a preparation method thereof, in particular to a method of preparing pantoprazole sodium. The method comprises the steps of 1) using 2-hydroxymethyl-3,4-dimethoxypyridine (II) as a start material to generate a compound of formula III under the action of a chloride; 2) subjecting the compound of formula III and 5-difluoromethoxy-2-thiol-1H-benzimidazole to condensation in the presence of an inorganic base so as to generate a compound of formula IV; 3) using an oxidant to oxidize the compound of formula IV to generate 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl-1H-benzimidazole, namely, pantoprazole; 4) allowing the obtained 5-difluoromethoxy-2-[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl-1H-benzimidazole to react with sodium hydroxide to generate a salt, namely, pantoprazole sodium (I); and optionally 5) refining the pantoprazole sodium. The product prepared via the method has high purity; related impurities, such as oxidation impurity, reduction impurity, decomposition impurity, have low contents.

The invention belongs to the field of medicines, and particularly relates to a gel preparation for treating functional uterine bleeding and application thereof. The gel preparation comprises the following active components of alvimopan or composition of alvimopan and ectoin, wherein the ratio of alvimopan to ectoin in parts by weight is 1:(3 to 5). The gel preparation has the advantages that the function of shortening the bleeding time of the functional uterine bleeding is realized by external administration or local vagina administration; when the alvimopan or the ectoin is singly used, the effect can be realized; when the alvimopan and the ectoin are jointly used, the effect is further improved.

The invention discloses an absorbable and degradable multipurpose biocompatible material. The raw materials of the absorbable and degradable multipurpose biocompatible material comprise chitosan, collagen and hyaluronic acid or sodium alginate in a weight ratio of (2 to 8): (0.5 to 3): (1 to 5); adding a dehydrating agent; generating hydrogel by a cross-linking reaction; and finally performing freeze-drying to prepare sponge or film. The absorbable and degradable multipurpose biocompatible material disclosed by the invention can be used as a bleeding-stopping anti-adhesion material, good in tissue adhesion, remarkable in anti-adhesion effect, capable of rapidly stopping bleeding, preventing adhesion, promoting tissue healing, preventing rebleeding, eliminating the inevitable virus hidden troubles of gelatine and animal collagen, and greatly improving safety, complete in degradation, capable of being absorbed and utilized by the body, and free of side effects on the body. The absorbable and degradable multipurpose biocompatible material can also be used as a scaffold for tissue engineering, artificial skin and the like, and good in biocompatibility, absorbability and degradability.

The invention discloses a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases, which is prepared from the following bulk drugs: leech, lumbricus, scorpio and pseudo-ginseng. The traditional Chinese medicine composition disclosed by the invention accords with the theories of traditional Chinese medicine pharmacology of removing stasis, promoting new and self-quenching wind through blood circulation; in addition, by utilizing the traditional Chinese medicine composition formula, the traditional Chinese medicine composition disclosed by the invention is capable of promoting circulation, removing stasis, removing blood stasis, clearing hematoma, stopping rehaemorrhagia, reducing intracranial pressure, eliminating encephaledema, adjusting whole-body blood, resisting stress reaction and improving microcirculation and has the unique curative effects to perennial serious hypertension, cerebral hemorrhage, stroke, coronary heart disease and cerebral thrombosis.

The invention relates to a hemostasis device, in particular to a gingival hemostasis device for children after tooth extraction. The invention provides a gingival hemostasis device after tooth extraction for children. The gingival hemostasis device can accelerate the hemostasis speed by applying medicine. A gingival hemostasis device for children after tooth extraction comprises a handle, a first connecting block, a second connecting block, a sleeve block and the like, the first connecting block is arranged on the right side of the handle, the second connecting block is rotatably arranged on the right side of the first connecting block, and the sleeve block is arranged on the right side of the lower portion of the second connecting block. A sleeve block is arranged on a pulled part in a sleeving mode, a dentist can rotate a pressing rod so that absorbent cotton can move downwards to extrude the pulled part, the aim of stopping bleeding is achieved, after the absorbent cotton and the pressing rod are reset, a pressing disc sprays medicine to the pulled part through a medicine spraying pipe under the reset effect of a third reset spring, re-bleeding can be prevented, and the aim of stopping bleeding is achieved. The aim of quickly stopping bleeding is fulfilled.