Absorbable and degradable multipurpose biocompatible material

Abstract

The invention discloses an absorbable and degradable multipurpose biocompatible material. The raw materials of the absorbable and degradable multipurpose biocompatible material comprise chitosan, collagen and hyaluronic acid or sodium alginate in a weight ratio of (2 to 8): (0.5 to 3): (1 to 5); adding a dehydrating agent; generating hydrogel by a cross-linking reaction; and finally performing freeze-drying to prepare sponge or film. The absorbable and degradable multipurpose biocompatible material disclosed by the invention can be used as a bleeding-stopping anti-adhesion material, good in tissue adhesion, remarkable in anti-adhesion effect, capable of rapidly stopping bleeding, preventing adhesion, promoting tissue healing, preventing rebleeding, eliminating the inevitable virus hidden troubles of gelatine and animal collagen, and greatly improving safety, complete in degradation, capable of being absorbed and utilized by the body, and free of side effects on the body. The absorbable and degradable multipurpose biocompatible material can also be used as a scaffold for tissue engineering, artificial skin and the like, and good in biocompatibility, absorbability and degradability.

Description

technical field [0001] The invention relates to the technical field of medical material production, in particular to an absorbable and degradable multipurpose biocompatible material. Background technique [0002] Postoperative adhesion refers to the abnormal structure formed by the combination of connective tissue fibers and adjacent tissues or organs. It is an inevitable pathophysiological process during postoperative healing. one. Every year, a large number of tissue adhesions occur after surgery, resulting in permanent disability and even life-threatening problems for patients. Surgical trauma, local ischemia, bleeding and bacterial infection may cause postoperative adhesions. According to statistics, the incidence of postoperative adhesion is about 50-90%, and it can also cause serious complications. So far, people are looking for various methods to prevent postoperative adhesions. Adjustment of surgical techniques, use of drugs and anti-adhesion isolation materials ...

AI Technical Summary

Problems solved by technology

At present, conventional hemostatic materials such as fibrin glue, gelatin sponge, medical gauze, collagen sponge, etc., but they each have certain shortcomings: the tissue adhesion of gelatin sponge and collagen sponge is poor, and the hemostatic function of both depends on Due to the sufficient amount of platelets and coagulation factors, the application is limited. Fibrin glue comes from the blood, which may cause viral infection. Medical gauze not only has a long healing period and obvious wound scars, but also is easy to stick during dressing changes. causing considerable pain to the patient

However, its biocompatibility and hemostatic function are poor