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Preparation method of medical alginic acid hemostatic material

A hemostatic material, alginic acid technology, applied in medical science, absorbent pads, bandages, etc., can solve the problems of complex production process and poor biocompatibility, and achieve simple process, good tissue adhesion, and extended shelf life and the effect of expiration

Inactive Publication Date: 2016-07-20
山东贝诺医药生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a preparation method of a medical alginic acid hemostatic material, which solves the problems of complicated production process and poor biocompatibility of the existing medical alginic acid hemostatic material

Method used

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preparation example Construction

[0024] A preparation method of medical alginic acid hemostatic material, comprising the steps of:

[0025] (1) Take alginic acid and dissolve it in a sodium hydroxide alkali solution with a concentration of 0.05 to 0.15 mol / L, and prepare a sodium alginate solution with a concentration of 2% to 5% by mass;

[0026] (2) adding the sodium alginate solution in step (1) to a saturated phosphate aqueous solution to obtain a mixed solution, adjusting the pH value of the mixed solution to 5-9, and aging;

[0027] (3) dissolving carbomer in distilled water, swelling to obtain carbomer solution, the mass volume ratio of the carbomer solution to distilled water is 1:10~20g / mL;

[0028] (4) Mix the solutions of step (2) and step (3) according to the volume ratio of 3-5:1, then filter and vacuum-dry to obtain the alginate / carbomer / phosphate hemostatic material.

Embodiment 1

[0030] A preparation method of medical alginic acid hemostatic material, comprising the steps of:

[0031] (1) Take alginic acid and dissolve it in a sodium hydroxide alkali solution with a concentration of 0.05 to 0.15 mol / L, and prepare a sodium alginate solution with a concentration of 2% to 5% by mass;

[0032] (2) Add the sodium alginate solution in step (1) to the phosphate saturated aqueous solution to obtain a mixed solution, the volume ratio of the sodium alginate solution and the phosphate saturated aqueous solution is 1 to 3:1, and adjust the pH value of the mixed solution 5-9, aging for 3-5 days;

[0033] Phosphate is any one or more of sodium salt, potassium salt, and ammonium salt.

[0034] (3) Dissolve carbomer in distilled water, stir and dissolve at 35-50°C for 2-3h to obtain a carbomer solution, the mass-volume ratio of the carbomer solution to distilled water is 1:10-20g / mL;

[0035] (4) Mix the solutions of step (2) and step (3) according to the volume ...

Embodiment 2

[0042] (1) Weigh 8 g of alginic acid, dissolve it with 0.1 mol / L sodium hydroxide solution, stir it magnetically for 1 hour, and then let it stand for 24 hours to prepare a sodium alginate solution with a concentration of 3.5% by mass.

[0043] (2) 2g (NH 4 ) 2 HPO 4 Dissolve in deionized water, stir magnetically for 1 h, and prepare saturated (NH 4 ) 2 HPO 4 solution; then sodium alginate solution and (NH 4 ) 2 HPO 4 The solutions were mixed according to the volume ratio of 2:1, and the pH of the solution was adjusted to 7 with ammonia water, and then aged for 4 days.

[0044] (3) Weigh 4 g of carbomer, dissolve it in 60 ml of deionized water, stir and dissolve at 40° C. for 2.5 h to prepare a carbomer solution.

[0045] (4) Mix the solution of step (2) and step (3) according to the volume ratio of 4:1, then filter and vacuum dry to obtain the alginate / carbomer / phosphate hemostatic material.

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Abstract

The invention discloses a preparation method of a medical alginic acid hemostatic material.The preparation method comprises the steps that alginic acid is dissolved in a sodium hydroxide alkaline solution with the concentration of 0.05-0.15 mol / L, and a sodium alginate solution with the mass percentage concentration of 2-5% is prepared; the sodium alginate solution is added into a phosphate saturated aqueous solution to obtain a mixed solution, the pH value of the mixed solution is adjusted to be 5-9, and aging is performed; Carbomer is dissolved in distilled water to be swelled to obtain a Carbomer solution, wherein the mass-volume ratio of the Carbomer solution to the distilled water is 1:(10-20) g / mL; the mixed solution and the Carbomer solution are mixed according to the volume ratio of (3-5):1, filtration and vacuum drying are performed, and therefore the alginate / Carbomer / phosphate hemostatic material is obtained.The technology is simple, the production cost is low, the final product is stored after being dried, and the storage condition is relatively easy to meet.

Description

technical field [0001] The invention relates to the technical field of external medicines, in particular to a preparation method of a medical alginic acid hemostatic material. Background technique [0002] At present, conventional hemostatic materials such as fibrin glue, gelatin sponge, medical gauze, collagen sponge, etc., but they each have certain shortcomings: the tissue adhesion of gelatin sponge and collagen sponge is poor, and the hemostatic function of both depends on Due to the sufficient amount of platelets and coagulation factors, the application is limited. Fibrin glue comes from the blood, which may cause viral infection. Medical gauze not only has a long healing period and obvious wound scars, but also is easy to stick during dressing changes. causing considerable pain to the patient. Therefore, the development of medical materials with both hemostatic and anti-adhesion effects has been a hot issue that people have been paying attention to in recent years. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/18A61L15/44A61L15/42A61L15/62A61L15/64
CPCA61L15/28A61L15/18A61L15/24A61L15/42A61L15/44A61L15/62A61L15/64A61L2300/232A61L2300/404A61L2300/418C08L5/04C08L33/00
Inventor 魏红艳
Owner 山东贝诺医药生物科技有限公司
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