Porcine-derived fibrin-electrostatic spinning nanofiber antibacterial hemostatic patch and preparation method thereof

Abstract

The invention relates to the technical field of medical hemostatic patches, and particularly relates to a porcine-derived fibrin-electrostatic spinning nanofiber antibacterial hemostatic patch and a preparation method thereof. The preparation method comprises the following steps of: preparing a porcine-derived fibrinogen and thrombin blended suspension, then spraying or soaking the blended suspension on thes urface of a silk fibroin nanofiber film prepared by an electrostatic spinning technology, and drying to prepare the porcine-derived fibrin hemostatic absorbable patch for postoperative hemostasis. The patch has an excellent hemostatic effect, combines a fibrin thrombin hemostatic mechanism with the mechanical properties of the antibacterial silk fibroin film to enhance the hemostatic effect, and is natural and absorbable, so that the hemostatic effect is improved, and the fibrinogen and thrombin are combined into one, four components are changed into a single component, preparation is not needed, and the patch can be used immediately after being opened, thereby greatly simplifying the problems of complex use and long time consumption of the existing fibrinogen adhesive; and the patch can be stored and transported at room temperature, and has significant technical, cost and clinical advantages.

Description

technical field

[0001] The invention relates to the field of medical hemostatic patches, in particular to a nanofiber antibacterial hemostatic patch. Background technique

[0002] Bleeding is one of the most common problems in surgery and trauma, and effective hemostatic methods and excellent hemostatic materials are particularly critical. Difficulty in suturing wound bleeding and postoperative suture oozing and other problems often bring troubles to the completion of surgery and postoperative recovery of patients. Choosing a suitable hemostatic dressing can effectively solve this problem.

[0003] At present, gelatin sponge and collagen sponge are mostly used as hemostatic auxiliary materials for medical surgery, and the latest hemostatic product, fibrin adhesive, is also used clinically. Medical surgical fibrin adhesive has good hemostasis, tissue compatibility and adhesiveness. By simulating the reaction process of the terminal stage of blood coagulation, it forms a visc...