Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A calcium ion exchange porous starch hemostatic material and its preparation method and application

A technology of porous starch and hemostatic material, applied in application, pharmaceutical formulation, surgery, etc., can solve the problems of insufficient particle uniformity, harsh reaction conditions, and large equipment dependence, and achieve the ability to increase the ability to adsorb water molecules, rich sources, The effect of promoting rapid degradation

Active Publication Date: 2021-11-02
ACADEMY OF MILITARY MEDICAL SCI
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the pore-forming methods of starch hemostatic materials mainly include physical pore-forming method, chemical pore-forming method and enzymatic pore-forming method; among them, the porous starch prepared by physical pore-forming method is highly dependent on equipment and high in cost
Porous starch prepared by chemical pore-forming method has problems such as relatively fragile pores and insufficient particle uniformity.
Porous starch prepared by enzymatic pore forming method has disadvantages such as long reaction time, high cost, harsh reaction conditions and difficult separation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A calcium ion exchange porous starch hemostatic material and its preparation method and application
  • A calcium ion exchange porous starch hemostatic material and its preparation method and application
  • A calcium ion exchange porous starch hemostatic material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0045] The preparation method of the present invention is screened out through a large number of experiments. In the process of preparing the porous starch hemostatic material, the ethanol alkali method, the reverse microemulsion method and the cross-linking reaction are combined for the first time, and the ethanol alkali method is used to prepare a rough surface. For the porous starch hemostatic material, use the inverse microemulsion method to control the particle size and particle size distribution range of the starch hemostatic material; secondly, when the present invention selects ethanol as the porogen, its addition is very important, adding Too little particle surface porous structure, low roughness, small specific surface area, only when within the scope of the present invention, the surface roughness of the obtained starch granules reaches a peak, and the liquid absorption rate also reaches a peak; finally, the present invention firstly uses calcium ions Exchanged into...

Embodiment 1

[0050] 1) Gelatinization: Take 10 g of corn starch and add it to 500 g of water to obtain a starch aqueous solution with a concentration of 2 wt%, mechanically stir at 50 rpm, heat at 45° C. for 1 min, cool to 20° C., add NaOH solution to adjust the pH of the starch aqueous solution to 9.0, A gelatinized starch solution is obtained.

[0051] 2) Emulsification, pore formation and crosslinking: Take 3g of emulsifier Span80 (Span 80) and add it to 250ml of liquid paraffin, stir for 10min until the two are evenly mixed, heat to 45°C, and then slowly add 500mL of the product obtained in step 1) The gelatinized starch solution is emulsified at a speed of 500rpm. After the gelatinized starch solution and the emulsifier solution are emulsified, add 10ml of absolute ethanol, stir mechanically at a speed of 500rpm for 15min, add 0.5mL of epichlorohydrin, and stir for 2h to generate crosslinking reaction.

[0052] 3) Calcium ion exchange: After the cross-linking reaction, under mechanic...

Embodiment 2

[0055] 1) Gelatinization: Get 2g of potato starch and add it into 100g of water to obtain a starch aqueous solution with a concentration of 2wt%. Mechanically stir at 100rpm, heat at 65°C for 5min, cool to 30°C, add NaOH solution to adjust the pH of the starch aqueous solution to 9.0, A gelatinized starch solution is obtained.

[0056] 2) Emulsification, pore formation and crosslinking: Take 1.6g of emulsifier Span60 (Span 60) and add it to 200ml of soybean oil, stir for 5 minutes until the two are evenly mixed, heat to 50°C, and then slowly add 100mL of step 1) to get The gelatinized starch solution was emulsified at a speed of 1000rpm. After the gelatinized starch solution and the emulsifier solution were emulsified, 50ml of polyethylene glycol was added, and after mechanical stirring at a speed of 1000rpm for 20min, 0.5mL of epichlorohydrin was added and stirred. 4h cross-linking reaction occurred.

[0057] 3) Calcium ion exchange: After the cross-linking reaction, under m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a calcium ion exchange porous starch hemostatic material and its preparation method and application. The calcium ion exchange porous starch hemostatic material of the present invention is prepared from starch through gelatinization, emulsification, pore formation, crosslinking and calcium ion exchange, and its raw materials include: starch, oil phase, porogen, emulsifier, calcium chloride, crosslinking agent and the remainder of water. The hemostatic material is made porous by ethanol alkali method to increase its specific surface area, cross-linked to increase its structural stability, reversed-phase microemulsion technology to control its particle size distribution, and the surface is modified with calcium ions to enhance its hemostatic performance , biodegradability and biocompatibility. The calcium ion-exchanged porous starch hemostatic material provided by the present invention has rich sources of main raw materials, good safety, and no residue, and can be widely used in the hemostasis application of substantive organs in the body and irregular bleeding such as diffuse bleeding, and does not require debridement after hemostasis , the hemostatic effect can continue to the postoperative period, and it can be degraded and absorbed in the human body after the postoperative period.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a calcium ion exchange porous starch hemostatic material and its preparation method and application. Background technique [0002] Although the hemostasis technology in surgery has been continuously improved in recent years, the existing hemostatic technology and hemostatic materials still exist for irregular bleeding of parenchymal organs and other diffuse bleeding in patients with coagulation dysfunction. insufficient. The emergence of some absorbable hemostatic materials, such as the absorbable hemostatic materials of fibrin glue, oxidized regenerated cellulose and microporous polysaccharides, has solved some of the above-mentioned problems, but there are still the following defects: [0003] Fibrin glue is an absorbable hemostatic material derived from animal or human plasma. Although it has a good hemostatic effect in some liver and kidney injury models of pati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/02
CPCA61L24/001A61L24/0042A61L24/0036A61L24/0015A61L24/08A61L24/02A61L2300/102A61L2300/418A61L2400/04A61L2400/12C08L3/02
Inventor 朱建军窦桂芳孙文种孟志云朱晓霞甘慧顾若兰吴卓娜
Owner ACADEMY OF MILITARY MEDICAL SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com