Antibacterial-hemostatic material with non-woven fabric fiber fabric structure and production method of antibacterial-hemostatic material

A fiber fabric and hemostatic material technology, which is applied in the field of electrospun fiber antibacterial-hemostatic material and its preparation, can solve the problems of high electric charge, difficult spinning, high viscosity, etc., achieves simple operation, improves hemostatic performance, and saves the amount of raw materials Effect

Inactive Publication Date: 2015-11-04
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high viscosity, high charge and strong intramolecular and intermolecular hydrogen bonding of chitosan in its acidic aqueous solution, it is difficult to spin successfully alone.

Method used

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  • Antibacterial-hemostatic material with non-woven fabric fiber fabric structure and production method of antibacterial-hemostatic material
  • Antibacterial-hemostatic material with non-woven fabric fiber fabric structure and production method of antibacterial-hemostatic material
  • Antibacterial-hemostatic material with non-woven fabric fiber fabric structure and production method of antibacterial-hemostatic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]Example 1: Preparation of electrospun fiber membrane: Add 9 grams of hexafluoroisopropanol to a beaker, add 1 g of polybutylene succinate (PBS) (molecular weight Mw=65000), stir at room temperature to make it Dissolving to obtain a spinning solution with a mass percentage concentration of 10 wt%. The prepared spinning solution is subjected to electrospinning to obtain an electrospun fiber membrane, and the prepared electrospun fiber membrane is desolventized in a vacuum oven for 24 hours.

[0028] Preparation of chitosan solution: dissolving glacial acetic acid in deionized water to prepare a concentration of 5 wt% acetic acid solution, weighing 1.5g of chitosan powder (deacetylation degree>90%, molecular weight 200000) was dissolved in 100g of the above-mentioned acetic acid solution A chitosan solution with a mass fraction of 1.5wt% was obtained.

[0029] A certain area of ​​the electrospun fiber membrane was cut and dipped into the chitosan solution, soaked for 30 min...

Embodiment 2

[0040] Example 2: Change the molecular weight of polybutylene succinate in Example 1 to Mw=100000, the preparation method is the same as Example 1, and the hemostatic time of the electrospun fiber membrane is shorter than that of gelatin sponge. The 2h contact sterilization rate of E.coli(DH5α) reached 83%.

Embodiment 3

[0041] Embodiment 3: change polybutylene succinate into polycaprolactone in embodiment 1, use amount is 0.6g, preparation method is the same as embodiment 1, but change the thrombin solution concentration into 5U / mL, electric The hemostasis time of the spun fiber membrane is shorter than that of the gelatin sponge. The 2h contact sterilization rate of E.coli(DH5α) reached 72%.

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Abstract

The invention relates to antibacterial-hemostatic material with a non-woven fabric fiber fabric structure and a production method of the antibacterial-hemostatic material and belongs to the technical field of biomedical materials. The antibacterial-hemostatic material is characterized in that aliphatic polyester is dissolved into solvent, an electrospun fibrous membrane is produced through static spinning, chitosan is loaded on the surface of the electrospun fibrous membrane, thrombin is further loaded on the surface of the electrospun fibrous membrane, and the antibacterial-hemostatic material is produced. The material features of the aliphatic polyester and the chitosan are utilized, the structure features such as high porosity and high specific surface area of the formed electrospun fibrous membrane are utilized, stable loading of the thrombin is performed by the crosslinking action of the chitosan and glutaraldehyde, and the antibacterial-hemostatic material with the non-woven fabric fiber fabric structure is formed. The antibacterial-hemostatic material has the advantages that the material is good in antibacterial and hemostatic effects, the antibacterial and hemostatic effects of the material are obviously better than those of commercially available gelatin sponge, the material is good in mechanical performance, easy to store and convenient to remove after being used, the production method of the material is simple to operate and capable of reducing raw material use amount, and the material is applicable to fields such as surgery and trauma first-aid.

Description

technical field [0001] The invention relates to an electrospun fiber antibacterial-hemostatic material with a non-woven fabric structure and a preparation method thereof, belonging to the technical field of biomedical polymer materials. Background technique [0002] Hemostatic materials and antibacterial materials play a very important role in post-injury first aid or medical rescue. At present, the hemostatic materials commonly used in clinical practice include gelatin, oxidized cellulose, fibrin glue, chitosan, etc., and the forms are often sponges, gauze, etc. The hemostatic properties of these commonly used hemostatic materials, especially the hemostatic speed, cannot fully meet all emergency medical procedures. the needs of the situation. As a biological agent, thrombin has a good hemostatic effect, but it is commercially available as a freeze-dried powder, which has disadvantages such as complicated application methods and easy inactivation. In addition, there are a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/26A61L15/44A61L15/42D06M15/03D06M16/00D04H1/435D04H1/728D06M101/32
Inventor 于建郭朝霞程慧慧熊曦
Owner TSINGHUA UNIV
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