Hemostatic material and preparation method thereof

A hemostatic material and solution technology, applied in the field of hemostatic material and its preparation, can solve the problems of not being suitable for hemostasis, hemostatic starch is not fast enough to stop bleeding, etc., and achieve excellent hemostatic effect, strong water absorption, hemostatic performance and improved water absorption.

Active Publication Date: 2017-05-31
成都迪康中科生物医学材料有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, hemostatic starch is not fast enough to stop bleeding, so

Method used

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  • Hemostatic material and preparation method thereof
  • Hemostatic material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Effect of the combination of different starch raw materials on the hemostatic performance of the hemostatic material

[0037] 1. Materials and methods

[0038] 1.1 Experimental animals: 90 healthy adult SD rats, male or female, weighing 210-240 g; 8 healthy adult New Zealand rabbits, male or female, weighing 1.9-2.1 kg, all provided by Guangdong Medical Experimental Animal Center.

[0039] 1.2 Test method

[0040]1.2.1 Determination of hemostasis time and bleeding volume 90 rats were randomly divided into 15 groups with 6 rats in each group according to the hemostatic materials prepared from the combinations of 15 kinds of starches in Table 1 below. All animals were fasted (without water) for 12 hours before the operation, anesthetized by intraperitoneal injection of 3% pentobarbital sodium 40 mg / kg body weight, and a longitudinal incision about 2 cm long was made under the costal arch along the midline of the abdomen, and the abdomen was cut along the midli...

Embodiment 2

[0049] Embodiment 2, a kind of hemostatic material

[0050] The hemostatic material described in Example 2 of the present invention is prepared by the following steps:

[0051] A) Acid hydrolysis: mix starch with 10% hydrochloric acid solution at a ratio of 1:5, stir to obtain a starch polysaccharide solution, place the above starch polysaccharide solution in a constant temperature water bath at 50°C for 15 hours, and keep stirring during the reaction. Speed ​​is 600rpm, obtains the starch polysaccharide solution after the acid hydrolysis;

[0052] B) Cross-linking: Add soybean oil, sodium hydroxide solution, emulsifier and epichlorohydrin to the starch polysaccharide solution after the above-mentioned acid hydrolysis treatment, and stir and mix; wherein, soybean oil, sodium hydroxide solution, emulsifier and cyclic The weight ratio of oxychloropropane is 2:1:0.06:0.1, and the reaction is 36h;

[0053] C) Anionization reaction: Add ethanol solution, monochloroacetic acid, so...

Embodiment 3

[0055] Embodiment 3, a kind of hemostatic material

[0056] The hemostatic material described in Example 3 of the present invention is prepared by the following steps:

[0057] A) Acid hydrolysis: mix starch with 38% hydrochloric acid solution at a ratio of 1:1, stir to obtain a starch polysaccharide solution, place the above starch polysaccharide solution in a constant temperature water bath at 30°C for 1 hour, and continue stirring during the reaction. The speed is 200rpm, and the starch polysaccharide solution after acid hydrolysis is obtained;

[0058] B) Cross-linking: Add soybean oil, sodium hydroxide solution, emulsifier and epichlorohydrin to the starch polysaccharide solution after the above-mentioned acid hydrolysis treatment, and stir and mix; wherein, soybean oil, sodium hydroxide solution, emulsifier and cyclic The weight ratio of oxychloropropane is 1:1:0.1:0.1, and the reaction is 36h;

[0059] C) Anionization reaction: add ethanol solution, monochloroacetic a...

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Abstract

The invention belongs to the field of a biomedical material, and particularly relates to a hemostatic material and a preparation method thereof. The hemostatic material is prepared from one or more of starch raw materials through acidolysis, crosslinking, negative ionization and positive ionization; carboxymethyl chitosan is connected onto anion degradable starch, so that the hemostatic effect and the water absorptivity of the prepared hemostatic material are obviously improved; in addition, the hemostatic effect is superior to that of Arista fast hemostatic powder; the obvious progress is obtained.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a hemostatic material and a preparation method thereof. Background technique [0002] The slow and small amount of bleeding caused by trauma can be stopped by its own function, but for major accidents, war injuries, and massive bleeding or concealed bleeding in surgical operations, the body alone cannot effectively stop the bleeding, which may cause shock or life-threatening of the injured. Therefore, safe, efficient, easy-to-use, and low-cost hemostatic materials are of great significance for clinical applications. [0003] At present, the hemostatic materials commonly used in the market mainly include oxidized fiber hemostatic materials, alginate protein gel hemostatic materials, chitosan hemostatic materials and degradable starch hemostatic materials. [0004] The oxidized fiber hemostatic material uses the carboxyl group on the acidic oxidized cellulose to com...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/08
CPCA61L24/001A61L24/0015A61L24/08A61L2300/232A61L2300/418A61L2400/04C08L5/08
Inventor 何俊淅李毅博
Owner 成都迪康中科生物医学材料有限公司
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