Potato starch-hyaluronic acid composite hemostatic powder and preparation method thereof

A potato starch and hyaluronic acid technology, applied in the field of medical devices, can solve the problems of poor water absorption of microporous polysaccharide particles, not firm enough gel, difficult strategic reserve, etc., and achieves easy degradation and discharge, good hemostatic effect, and low toxicity. residual effect

Active Publication Date: 2013-04-24
SICHUAN SANTAI PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although its hemostatic effect is excellent and its clinical acceptance is high, there are still obvious shortcomings: first, Arista is cross-linked by epichlorohydrin, which may release potentially toxic substances during the degradation process; second, its microporous polysaccharide particles The water absorption is

Method used

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  • Potato starch-hyaluronic acid composite hemostatic powder and preparation method thereof
  • Potato starch-hyaluronic acid composite hemostatic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 40g of high-purity potato starch granules and add them to deionized water, stir at a constant speed below 25°C to prepare a 40% starch suspension, adjust the pH of the suspension to 9.0 with 2% sodium hydroxide, and activate it 1 hour; slowly add 20ml of acetic anhydride / adipic acid mixture prepared at a ratio of 20:1 under uniform stirring conditions, and slowly add 2% sodium hydroxide to ensure that the pH of the reaction system is maintained at 9.0. Control the temperature of the process water bath to not be higher than 39°C; after the acetic anhydride / adipic acid mixture is added, continue to maintain the pH value at 9.0 with sodium hydroxide for 1 hour; slowly add succinic anhydride to the system until the pH value of the system is reached Until no change occurs, this process control is completed in about 2 hours. Neutralize the excess acid in the reaction system with 2% sodium hydroxide, wash with a large amount of deionized water several times, and filter. ...

Embodiment 2

[0033] Take 40g of high-purity potato starch granules and add them to deionized water, stir at a constant speed below 30°C to prepare a 40% starch suspension, adjust the pH of the suspension to 9.0 with 2% sodium hydroxide, and activate it 1 hour; slowly add 20ml of acetic anhydride / adipic acid mixture prepared at a ratio of 15:1 under uniform stirring conditions, and slowly add 2% sodium hydroxide to ensure that the pH of the reaction system is maintained at 9.0. Control the temperature of the process water bath to not be higher than 39°C; after the acetic anhydride / adipic acid mixture is added, continue to maintain the pH value at 9.0 with sodium hydroxide for 1 hour; slowly add succinic anhydride to the system until the pH value of the system is reached Until no change occurs, this process control is completed within 1.5 hours. Neutralize the excess acid in the reaction system with 2% sodium hydroxide, wash with a large amount of deionized water, filter and make a 40% suspe...

Embodiment 3

[0036] Take 40g of high-purity potato starch granules and add them to deionized water, stir at a constant speed below 30°C to prepare a 40% starch suspension, adjust the pH of the suspension to 9.5 with 2% sodium hydroxide, and activate it 1 hour; slowly add 20ml of acetic anhydride / adipic acid mixture prepared at a ratio of 20:1 under uniform stirring conditions, and slowly add 2% sodium hydroxide to ensure that the pH of the reaction system is maintained at 9.5. Control the temperature of the process water bath to not be higher than 35°C; after the acetic anhydride / adipic acid mixture is added, continue to maintain the pH at 9.0 with sodium hydroxide for 1 hour; slowly add succinic anhydride to the system until the pH of the system is reached Until no change occurs, this process control is completed within 2 hours. Neutralize the excess acid in the reaction system with 2% sodium hydroxide, wash with a large amount of deionized water several times, and filter.

[0037] The f...

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Abstract

Belonging to the field of medical equipment, the invention particularly relates to a composite hemostatic powder and a preparation method thereof. The composite hemostatic powder provided in the invention is mainly prepared by: subjecting potato starch to modification crosslinking by acetic anhydride/adipic acid-succinic anhydride, then compounding the potato starch with a hyaluronate solution, and performing drying. The preparation method employs a relatively safe modification crosslinking pattern with low-toxic residue, and the security is significantly improved. Performance of the hemostatic powder can be adjusted by pregelatinization or surface pore-forming after starch modification crosslinking and by adopting different drying and sterilization ways. Also, blending of potato starch and sodium hyaluronate makes full use of the respective advantages of the two biological materials. Compared with existing products on the market, the composite hemostatic powder provided in the invention has excellent water-absorbing capacity, adhesion, gel forming property and anti-floating property, and shows better use performance. Being able to degrade completely in vivo, the hemostatic powder has no toxic or side effect and has definite effects, and also can be further compounded with other hemostatic materials, thus having broad market prospects.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a potato starch-hyaluronic acid composite hemostatic powder and a preparation method thereof. Background technique [0002] Bleeding is defined as the flow of blood from blood vessels or the heart to interstitial spaces, body cavities, or outside the body. Because blood has important physiological functions, excessive blood loss will endanger the health of patients and even endanger their lives. Although the blood of normal people has the function of coagulation, trauma, disease and surgery will cause the human body to bleed continuously, so some hemostatic means must be used, such as using appropriate hemostatic materials. The development of hemostatic materials has always been one of the focuses in the fields of clinical medicine, biomaterials and medical devices. From ancient sore medicine, honey, barley to cotton cloth and cotton yarn, to new bioabsorbable hemostatic agents, ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42A61K31/728A61K9/14A61P7/04C08B31/00C08B31/04A61K31/715
Inventor 袁暾
Owner SICHUAN SANTAI PHARM TECH CO LTD
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