Potato starch-hyaluronic acid composite hemostatic powder and preparation method thereof

Abstract

Belonging to the field of medical equipment, the invention particularly relates to a composite hemostatic powder and a preparation method thereof. The composite hemostatic powder provided in the invention is mainly prepared by: subjecting potato starch to modification crosslinking by acetic anhydride / adipic acid-succinic anhydride, then compounding the potato starch with a hyaluronate solution, and performing drying. The preparation method employs a relatively safe modification crosslinking pattern with low-toxic residue, and the security is significantly improved. Performance of the hemostatic powder can be adjusted by pregelatinization or surface pore-forming after starch modification crosslinking and by adopting different drying and sterilization ways. Also, blending of potato starch and sodium hyaluronate makes full use of the respective advantages of the two biological materials. Compared with existing products on the market, the composite hemostatic powder provided in the invention has excellent water-absorbing capacity, adhesion, gel forming property and anti-floating property, and shows better use performance. Being able to degrade completely in vivo, the hemostatic powder has no toxic or side effect and has definite effects, and also can be further compounded with other hemostatic materials, thus having broad market prospects.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a potato starch-hyaluronic acid composite hemostatic powder and a preparation method thereof. Background technique [0002] Bleeding is defined as the flow of blood from blood vessels or the heart to interstitial spaces, body cavities, or outside the body. Because blood has important physiological functions, excessive blood loss will endanger the health of patients and even endanger their lives. Although the blood of normal people has the function of coagulation, trauma, disease and surgery will cause the human body to bleed continuously, so some hemostatic means must be used, such as using appropriate hemostatic materials. The development of hemostatic materials has always been one of the focuses in the fields of clinical medicine, biomaterials and medical devices. From ancient sore medicine, honey, barley to cotton cloth and cotton yarn, to new bioabsorbable hemostatic agents, ...

AI Technical Summary

Problems solved by technology

Although its hemostatic effect is excellent and its clinical acceptance is high, there are still obvious shortcomings: first, Arista is cross-linked by epichlorohydrin, which may release potentially toxic substances during the degradation process; second, its microporous polysaccharide particles The water absorption is still poor, and there is still room for improvement in concentrating coagulation factors and promoting the coagulation process; the third is that its adhesion is not good, it is easy to float and the gel formed is not firm enough; It is more difficult to use it as a strategic reserve in the rich majority of our country

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