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Porous styptic powder and preparation method thereof

A technology of hemostatic powder and radiation irradiation, which is applied in the field of preparation of porous cross-linked hemostatic powder, can solve the problems of low specific surface area, limit the application development of high-adsorption materials, and large pore size of porous cross-linked gelatin sponge, and achieve large specific surface area, Small pore size and strong adsorption effect

Active Publication Date: 2016-09-07
厦门凝赋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the porous cross-linked gelatin sponge obtained in this patent has a large pore size, mainly concentrated in 20 to 70 microns, resulting in a low specific surface area, which limits its application and development as a high-adsorption material

Method used

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  • Porous styptic powder and preparation method thereof
  • Porous styptic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Dissolve 15 grams of gelatin in 85 grams of water and stir well to obtain a 15% gelatin solution. Pour the gelatin solution into the mold, quickly put it into a refrigerator preset at -20°C, and quickly cool it down from room temperature to -20°C, store it for 24 hours, and quickly transfer it to a portable refrigerator with a measured temperature of 0°C ( containing ice-water mixture), cobalt-60 gamma ray irradiation dose is 30kGy to obtain hydrogel. Transfer the hydrogel to a freeze dryer for pre-freezing, the pre-freezing temperature is -80°C, and then dry to obtain a porous material. The obtained porous material is pulverized and sieved with a 100-mesh sieve to obtain a porous cross-linked powder. The joint degree is 48.7±2.1%, tested with ASAP 2010BET specific surface tester (Micromeritics, USA), the BET specific surface area is 103.71m 2 / g, 24h water absorption rate is 2216.0±7.5%.

Embodiment 2

[0027] Dissolve 1 gram of collagen in 99 grams of water and stir well to obtain a 1% collagen solution. Pour the collagen solution into the mold, quickly put it into an ultra-low temperature refrigerator set at -70°C, and quickly cool it down from room temperature to -70°C, then store it for 24 hours, and quickly transfer it to a portable refrigerator with a temperature of -10°C Inside, the collagen hydrogel was obtained by irradiating 1 kGy with electron beam radiation. Transfer to a freeze dryer for pre-freezing. The pre-freezing temperature is -20°C. After freeze-drying, the obtained porous collagen cross-linked sponge has a water absorption rate of 1634.0 ± 279.0% in 24 hours.

Embodiment 3

[0029] Dissolve 15 grams of carboxymethyl chitosan in 85 grams of water and stir evenly to obtain a 15% carboxymethyl chitosan solution. Pour the solution into a mold, and quickly put it into liquid nitrogen at a temperature of -196°C for rapid cooling, so that the temperature is rapidly dropped from room temperature to -196°C. Then store for 24 hours, quickly transfer to a portable refrigerator with a preset temperature of -20°C, irradiate with cobalt-60γ-rays at a dose of 30kGy, transfer to a freeze dryer for pre-freezing, and the pre-freezing temperature is -70°C. Carry out drying, the obtained porous material is pulverized, sieved with 100 mesh sieves, is tested with ASAP 2010BET specific surface tester (Micromeritics, USA), obtains that BET specific surface area is 52.17m 2 / g, the degree of crosslinking is 24.6±3.3%, and the 24h water absorption rate is 1800.7±10.6%.

[0030] figure 1 The microstructure of the porous powder prepared according to the method of Example ...

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Abstract

The invention discloses porous styptic powder and a preparation method of the porous styptic powder. The preparation method comprises the following steps: rapidly cooling a solution containing a material needing to be crosslinked, carrying out ray irradiation crosslinking under low temperature, and carrying out freeze drying, thus obtaining the porous styptic powder. In the preparation method, superfine small ice crystals are obtained through rapid cooling, during the irradiation, the low temperature is guaranteed, so that the small ice crystals do not melt and are sized after the irradiation. With the adoption of the preparation method, the porous crosslinking material with small pore diameter, large porosity and large specific surface area is obtained; the ray irradiation crosslinking is adopted, in the preparation process, a crosslinking agent is not introduced, therefore, the prepared material has no biotoxicity caused by the crosslinking agent, and therefore, the preparation process is a safe, nontoxic and environmentally friendly production process; the prepared material has good prospects in the fields of hemostatic materials, drug carriers and the like.

Description

technical field [0001] The invention discloses a preparation method of a porous hemostatic powder, in particular a preparation method of a porous cross-linked hemostatic powder which does not introduce a cross-linking agent in the preparation process. Background technique [0002] Porous cross-linked materials, because of their high porosity, low density, and easy functional modification and loading, have broad applications and demands in the fields of tissue engineering, hemostatic materials, drugs and molecular carriers, biocatalysis, and inert fillers. However, due to the need to shape the material after pore formation, it is difficult to crosslink the shaped solid material by the traditional method of using a cross-linking agent. The pore can only be formed by freeze-drying. The obtained material has a large pore size and a small specific surface area, which cannot meet the requirements of high adsorption. and the need for drug delivery. In addition, other current metho...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0038A61L26/0085A61L2400/04C08L89/00C08L89/06C08L5/08C08L1/286
Inventor 许零马晓春
Owner 厦门凝赋生物科技有限公司
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