Novel absorbable hemostatic material

A hemostatic material and a new type of technology, applied in the field of medicine, can solve the problems of complicated preparation of hemostatic powder, easy to cause inflammatory reactions, and long absorption time, and achieve the effects of short absorption time in the body, promotion of wound healing, and simple preparation method

Active Publication Date: 2013-12-18
QINGDAO ZHONGTENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the medical hemostatic materials in China are water-soluble hemostatic gauze, but gauze has no anti-inflammatory and antibacterial effect, and has defects such as slow hemostasis, long absorption time in the body, and easy to cause inflammatory reactions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: The novel absorbable hemostatic material is a guluronic acid polymer formed by complexation reaction or crosslinking reaction of guluronic acid monomer. The guluronic acid polymer is in the form of powder macroscopically, and its microstructure unit is a porous particle. The diameter of the porous particle is 500-1000 nm, and 100-150 holes are formed on each porous particle. The guluronic acid monomer is extracted from seaweed plants. The seaweed plant is kelp among brown algae. The preparation method of the guluronic acid monomer is acid degradation. The preparation method of the guluronic acid polymer is to use glucuronic acid monomers as materials and dicumyl oxide as a crosslinking agent. Body, polyvinyl alcohol, lavender essential oil and clove essential oil are cross-linked in a constant temperature reaction kettle for 6 hours.

Embodiment 2

[0016] Embodiment 2: The novel absorbable hemostatic material is a guluronic acid polymer formed by complexation reaction or crosslinking reaction of guluronic acid monomer. The guluronic acid polymer is in the form of powder macroscopically, and its microstructure unit is a porous film. The thickness of the porous film is 500-1000nm, and 100-150 holes are formed on each porous film. 100 to 150 pores are formed on each porous particle. The guluronic acid monomer is extracted from seaweed plants. The seaweed plant is kelp among brown algae. The preparation method of the guluronic acid monomer is acid degradation. The preparation method of the guluronic acid polymer is to use glucuronic acid monomers as materials and dicumyl oxide as a crosslinking agent. Body, polyvinyl alcohol, lavender essential oil and clove essential oil are cross-linked in a constant temperature reaction kettle for 6 hours.

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Abstract

The invention relates to a novel absorbable hemostatic material which is easy in preparation method, low in cost and good in hemostatic effect. At present most medical hemostatic materials in China are water-soluble hemostatic gauze, and the gauze does not have anti-inflammatory and anti-bacterial effects when being used for hemostasis, and has the defects that the hemostatic speed is low, the in vivo absorption time is long, an inflammatory reaction is easy to cause and the like, and therefore people turns to hemostatic powder, however, as existing hemostatic powder is complex to prepare, high in price, not ideal in hemostatic effect and the like, the hemostatic powder is not applied as a mainstream hemostatic product. The novel absorbable hemostatic material is a guluronic acid polymer generated by an complexation reaction or crosslinking reaction of a guluronic acid monomer, polyvinyl alcohol, lavender essential oil and clove essential oil. The novel absorbable hemostatic material is good in hemostatic effect, and has the advantages that the hemostatic speed is high, the in vivo absorption time is short, broad-spectrum sterilization and anti-inflammation effects are achieved, wound healing is promoted and the like, and in addition, the novel absorbable hemostatic material is not affected by the size and position of a wound surface, and widely applicable to the fast hemostasis for war wound, trauma and other conditions.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a novel absorbable hemostatic material with simple preparation method, low cost and good hemostatic effect. Background technique [0002] Hemorrhage is the first cause of death in war injuries and the second cause of death in trauma. Hemorrhage is also the main cause of death in the operating room of trauma patients. Rapid and effective control of hemorrhage can significantly reduce the death caused by hemorrhage. At present, most of the medical hemostatic materials in China are water-soluble hemostatic gauze, but gauze has no anti-inflammatory and antibacterial effect, and has defects such as slow hemostasis, long absorption time in the body, and easy to cause inflammatory reactions. Therefore, people turn their attention to another The hemostatic material—hemostatic powder, however, has not been applied as a mainstream hemostatic product due to the complicated preparation, hig...

Claims

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Application Information

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IPC IPC(8): A61L15/40A61L15/28A61L15/24A61L15/44
Inventor 李洪波
Owner QINGDAO ZHONGTENG BIOTECH
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