Alkyl modified chitosan/mesoporous silicon dioxide composite quick hemostatic powder and preparation method thereof

Abstract

The invention discloses an alkyl modified chitosan / mesoporous silicon dioxide composite quick hemostatic powder and a preparation method thereof. The method comprises the following steps: 1) preparation of alkyl modified chitosan; 2) preparation of mesoporous silicon dioxide particles; and 3) preparation of composite quick hemostatic powder: dissolving the alkyl modified chitosan in an acetic acid water solution, adding polyethyleneglycol 20000 to be dissolved, adding the mesoporous silicon dioxide particles prepared in the step 2), stirring at room temperature, freeze-drying the precipitate, suspending the precipitate in dimethylsulfoxide, regulating the pH value, centrifuging, washing with deionized water, and freeze-drying to obtain the alkyl modified chitosan / mesoporous silicon dioxide composite quick hemostatic powder. The hemostatic powder disclosed by the invention can quickly stop bleeding, and is suitable for pre-hospital emergency treatment of severe bleeding wounded persons. The material has the advantages of high hemostatic speed, excellent hemostatic effect, favorable biocompatibility and histocompatibility, and no side effect.

Description

Technical field [0001] The invention relates to a hemostatic material and a preparation method, in particular to an alkyl-modified chitosan / mesoporous silica composite rapid hemostatic powder and a preparation method thereof. Background technique [0002] Bleeding from trauma is one of the most common injuries at the scene of various accidents on the battlefield and peacetime. Loss of control of bleeding is the leading cause of death at the scene and serious complications (such as amputation). Therefore, it is of great significance to effectively control the bleeding of the wounded at the scene and before the hospital. Tourniquets are life-saving equipment that can control bleeding, but many parts of the human body, such as the chest, abdomen, head, and neck, cannot be used. Traditional hemostatic materials (such as cotton yarn, bandages) have poor hemostatic effects for common wounds such as irregular shapes, deep, narrow, and arterial ruptures. Therefore, the development of f...

AI Technical Summary

Problems solved by technology

Hudson et al. studied the biosafety of mesoporous silicon particles with different particle sizes and pore sizes in subcutaneous, intraperitoneal and intravenous, and the results showed that although the local tissue reaction of mesoporous silicon particles is benign, they enter blood vessels and tissues and organs. Mesoporous silica particles can cause severe systemic toxicity

[0007] The inventors of the present application believe that the alkyl modified chitosan acetic acid solution of Srinivasa R.Raghavan research group can make whole blood gel immediately, but the problem of water residue after lower gel strength and gelation is not Conducive to the control of hemostasis in practical applications; mesoporous silicon materials can absorb water in blood and concentrate local coagulation components, thereby achieving rapid hemostasis, but the biological safety hazards caused by the easy residue of particles cannot be ignored

Images