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Styptic powder and preparation method thereof

A technology of hemostatic powder and starch, applied in the directions of pharmaceutical formulation, surgery, drug delivery, etc., can solve the problems of unfavorable industrial production, contain many impurities, complicated steps, etc., and achieve the effects of easy industrial operation, reduction of impurity content, and simple preparation method.

Active Publication Date: 2017-09-29
深圳市和福汇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic material can accelerate the aggregation of red blood cells and platelets to a certain extent, but this method requires ball milling and activation of starch, the steps are complicated and contain many impurities, which is not conducive to industrial production

Method used

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  • Styptic powder and preparation method thereof
  • Styptic powder and preparation method thereof
  • Styptic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A kind of hemostatic powder, its preparation comprises the steps:

[0038] 1) Preparation of etherified starch: Dissolve 6g of hydroxypropyl starch in 200mL of deionized water, 4g of sodium hydroxide in 40mL of deionized water, and 8g of 3-chloro-2-hydroxypropyltrimethylammonium chloride. In 20mL deionized water; successively add the aqueous solution of NaOH and the aqueous solution of 3-chloro-2-hydroxypropyltrimethylammonium chloride dropwise to the aforementioned hydroxypropyl starch solution, and stir and react at 50°C for 24h; After the completion, precipitate with absolute ethanol, wash several times, and obtain etherified starch with a substitution degree of 5-30% after vacuum drying;

[0039] 2) Weigh 0.5 g of the etherified starch obtained in the above step 1) and dissolve it in deionized water, stir evenly, and adjust the pH to 12 with ammonia water to obtain a starch suspension;

[0040] 3) Measure 100mL of n-hexane, add 2.34g of Span 60, and emulsify to obt...

Embodiment 2

[0044] A kind of hemostatic powder, its preparation comprises the steps:

[0045] 1) Preparation of etherified starch: Dissolve 6g of cornstarch in 200mL of deionized water, 4g of sodium hydroxide in 40mL of deionized water, and 40g of 2-chloroethyldiethylamine in 20mL of deionized water; The aqueous solution of 2-chloroethyldiethylamine and the aqueous solution of 2-chloroethyldiethylamine were added dropwise to the aforementioned cassava starch solution, and stirred and reacted at 60°C for 24 hours; 50-80% etherified starch;

[0046] 2) Weigh 0.7 g of the etherified starch obtained in the above step 1) and dissolve it in deionized water, stir evenly, and adjust the pH to 8 with sodium hydroxide to obtain a starch suspension;

[0047] 3) Measure 100mL of n-heptane, add 2.34g of Span 80, and emulsify to obtain a mixed solution;

[0048] 4) Add the starch suspension obtained in step 2) to the mixed solution obtained in step 3), then add 0.3 g of sodium tripolyphosphate, and r...

Embodiment 3

[0051] A kind of hemostatic powder, its preparation comprises the steps:

[0052] 1) Measure 100mL of n-hexane, add 2.34g of Span 80 to emulsify; weigh 0.5g of potato starch and dissolve it in deionized water, then add it to the cyclohexane mixture, add 0.3g of epichlorohydrin, and react at 25°C for 5 Hour;

[0053] 2) Product collection: after the reaction, dry under reduced pressure to remove n-hexane, wash the product with absolute ethanol, vacuum dry, grind, and sterilize to obtain starch hemostatic powder.

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Abstract

The invention discloses a styptic powder and a preparation method thereof. The method comprises the following steps: dissolving a starch raw material in water, emulsifying and dispersing, performing cross-linking reaction, drying under reduced pressure, washing, drying, and sterilizing. The styptic powder prepared by the preparation method has the characteristics of rapid adhesion to wound, rapid water absorption, arresting bleeding, and biodegradable property. The invention also discloses the styptic powder prepared by the method of the invention.

Description

technical field [0001] The invention relates to the field of biomedical materials. More specifically, it relates to a hemostatic powder and a preparation method thereof. Background technique [0002] Today, natural disasters, car accidents, fires, local wars and other disasters continue to occur, social security is threatened, bloody accidents occur from time to time, minor bleeding may lead to shock, and even death in severe cases. According to relevant studies, the blood in the whole body of an adult normally accounts for 7%-8% of the body weight. When the injured person bleeds more than 20% of the total blood volume at one time, shock symptoms such as pale face, blood pressure drop, and weak pulse will appear. When the bleeding amount of the wounded reaches 40% of the total blood volume, it will be life-threatening, so the first problem encountered in surgical operations, injury wounds and accidents is exactly hemostasis. Traditional hemostasis methods, such as bandagin...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00C08B31/00C08B31/12
CPCA61L24/00A61L24/0036A61L24/08A61L2400/04C08B31/003C08B31/006C08B31/125C08L3/08C08L3/04
Inventor 徐福建胡杨苏洋李杨罗旭
Owner 深圳市和福汇生物科技有限公司
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