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Preparation method and applications of hemostatic material

A technology of hemostatic materials and raw materials, applied in the field of materials, can solve the problems of slow degradation and absorption of chitosan, poor water absorption performance, and affect the absorbability and water absorption performance of hemostatic microspheres, so as to reduce the risk of wound infection and reduce the risk of wound infection , enhance the effect of hemostatic effect

Inactive Publication Date: 2020-04-24
ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the hemostatic microspheres prepared by these methods, chitosan is evenly distributed in the microspheres. However, chitosan is slowly degraded and absorbed in the body, and its water absorption performance is worse than that of modified starch. If the proportion of chitosan added is too high, it will affect the reliability of the hemostatic microspheres. Absorption properties and water absorption properties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Using sodium carboxymethyl starch as the raw material, the raw material powder is boiled and granulated, screened through a sieve, and 100-200 mesh microspheres are selected, which are recorded as the A0 sample. Disperse 10 g of the above-mentioned carboxymethyl starch microspheres in 100 mL of dimethyl sulfoxide, add 50 mg of N, N'-carbonyl bis(1,2,4-triazole) at the same time, stir for 4 hours, centrifuge, and remove the supernatant Finally, wash three times with dimethyl sulfoxide, add 50mL of new dimethyl sulfoxide, and then slowly add 50mL of chitosan solution with Mw of 50kD and DD of 95%, concentration 10mg / mL, coupling reaction After 2 hours, centrifuge to remove the supernatant, wash with absolute ethanol 3 times, and dry the precipitate in vacuum to obtain the hemostatic material (A1 sample) of the present invention.

[0026] The water absorption capacity of the modified starch-chitosan composite microspheres was determined by centrifugation, and the water abs...

Embodiment 2

[0033] Corn starch was emulsified and cross-linked by sodium trimetaphosphate, washed with alcohol, dried, screened through a sieve, and cross-linked starch microspheres of 40-100 mesh were selected (the cross-linked starch microspheres were designated as B0 sample). Disperse 20g of the above-mentioned crosslinked starch microspheres in 100mL of dimethyl sulfoxide, add 500mg of carbonyldiimidazole, stir for 24 hours, centrifuge, remove the supernatant, wash three times with dimethyl sulfoxide, and add 50mL of fresh dimethylsulfoxide base sulfoxide. Slowly add 40mL of chitosan solution with Mw of 300kD and DD of 90%, the concentration is 10mg / mL, and the coupling reaction is carried out for 24 hours. After the supernatant is removed by centrifugation, it is washed 3 times with absolute ethanol, and the precipitate is vacuum-dried The hemostatic material (B1 sample) of the present invention can be obtained. The water absorption capacity of the modified starch-chitosan composite...

Embodiment 3

[0040] Pregelatinized potato starch is used as raw material, the raw material powder is boiled and granulated, screened through a sieve, and 40-200 mesh microspheres are selected. Disperse 5 g of the above-mentioned pregelatinized potato starch microspheres in 100 mL of dimethyl sulfoxide, add 75 mg of N, N'-carbonyl bis(1,2,4-triazole) at the same time, stir for 2 hours, centrifuge, remove the After the clear solution, wash it three times with dimethyl sulfoxide, add 50 mL of new dimethyl sulfoxide, and then slowly add 10 mL of chitosan solution with a Mw of 5 kD and a DD of 55%, at a concentration of 1 mg / mL. After 12 hours of joint reaction, after centrifugation and removing the supernatant, wash with absolute ethanol for 3 times, and dry the precipitate in vacuum to obtain the hemostatic material of the present invention.

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Abstract

The invention discloses a preparation method and applications of a hemostatic material. According to the invention, by using a microsphere surface modification method, the modified starch of a modified starch microsphere shell layer is activated and coupled with chitosan amino to obtain modified starch hemostatic microspheres with the surface modified with chitosan, wherein the modified starch microspheres have good water absorption performance and can rapidly absorb moisture in blood and concentrate blood coagulation factors so as to achieve the rapid hemostatic effect, the chitosan modification can enhance the hemostatic effect, activate blood coagulation factors and form blood coagulation blocks so as to promote blood coagulation, and chitosan has a certain antibacterial activity, so that the modification of the surface with chitosan can reduce the infection risk, the addition amount of chitosan can be reduced through surface modification, and the water absorption performance and the degradation and absorption performance of the modified starch microspheres are influenced to the minimum extent; and the hemostatic powder prepared by the invention can be used for quickly stoppingbleeding of bleeding parts such as body surfaces, in-vivo tissues, organs and the like, has a certain antibacterial function, and reduces the wound infection risk.

Description

technical field [0001] The invention relates to the field of materials, in particular to a preparation method and application of a hemostatic material. Background technique [0002] With the continuous deepening of people's understanding of hemostatic materials, more and more attention is paid to the safety of materials, and the requirements are getting higher and higher. For example, the requirements: intraoperative hemostatic materials can be absorbed, can be metabolized in the body, non-human and animal-derived , no immune response, no toxic side effects, reduce the chance of postoperative infection, etc. [0003] Currently commonly used hemostatic materials include absorbable gelatin sponge, collagen sponge, oxidized regenerated cellulose, and natural biopolysaccharide hemostatic materials. Gelatin and collagen are derived from animal tissues, and are prone to immunogenicity. The clinical manifestations are allergic reactions and wound infection complications in patient...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/08
CPCA61L24/001A61L24/0015A61L24/08A61L2300/232A61L2300/404A61L2400/04C08L5/08C08L3/02
Inventor 吕国军
Owner ZHANGJIAGANG IND TECH RES INST CO LTD DALIAN INST OF CHEM PHYSICS CHINESE ACADEMY OF SCI
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